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Leull93) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance. Diabetologia,1993.36(5):p.414-22. 31. Engelman, J.A., X.L. Zhang, and M.P. Lisanti, Genes encoding human caveolin-1 and-2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA 7G) that is frequently deleted in human cancers. FEBS Lett, 1998.436(3):p.403-10. 32. Volonte, D., et al., Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Mol Biol Cell,2002. 13(7):p.2502-17. 33. Williams, T.M., et al., Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol Biol Cell,2003.14(3):p.1027-42. 34. Capozza, F., et al., Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. Am J Pathol, 2003.162(6):p.2029-39. 35. Wu, D., et al., Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer. Cancer Res,2002.62(8):p.2423-9. 36. Fong, A., et al., Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation. Am J Clin Pathol,2003.120(1):p.93-100. 37. Muller, G., et al., Regulation of lipid raft proteins by glimepiride-and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes. Biochem Pharmacol,2005.69(5):p.761-80. 38. Blair, A., et al., Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation. J Biol Chem,1999.274(45):p.32512-9. 39. Razani, B., et al., Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem,2001.276(41):p. 38121-38. 40. Miyawaki-Shimizu, K., et al., siRNA-induced caveolin-1 knockdown in mice increases lung vascular permeability via the junctional pathway. Am J Physiol Lung Cell Mol Physiol,2006.290(2):p. L405-13. 41. Lei, M.G, et al., Regulation of cellular caveolin-1 protein expression in murine macrophages by microbial products. Infect Immun,2005.73(12):p. 8136-43. 42. Medina, F.A., et al., Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection. Infect Immun,2006.74(12):p.6665-74. 43. Garrean, S., et al., Caveolin-1 regulates NF-kappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide. J Immunol, 2006.177(7):p.4853-60. 44. Gadjeva, M., et al., Caveolin-1 modifies the immunity to Pseudomonas aeruginosa. J Immunol,2010.184(1):p.296-302. 45. Eskandari, M.K., et al., Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia. J Immunol, 1992.148(9):p.2724-30. 46. Poltorak, A., et al., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice:mutations in Tlr4 gene. Science,1998.282(5396):p.2085-8. 47. Echtenacher, B., et al., Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis. Infect Immun,2001.69(12): p.7271-6. 48. Vazquez-Torres, A., et al., Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella:importance of the Kupffer cell network. J Immunol,2004.172(10):p.6202-8. 49. Rittirsch, D., et al., Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc,2009.4(1):p.31-6. 50. Wesche-Soldato, D.E., et al., In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood,2005.106(7):p.2295-301. 51. Guo, L., et al., Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response. J Biol Chem,2009.284(30):p. 19826-34. 52. Gao, X., et al., Reversibility of increased microvessel permeability in response to VE-cadherin disassembly. Am J Physiol Lung Cell Mol Physiol,2000. 279(6):p. L1218-25. 53. Steinman, C.R., et al., Domain-directed polymerase chain reaction capable of distinguishing bacterial from host DNA at the single-cell level: characterization of a systematic method to investigate putative bacterial infection in idiopathic disease. Anal Biochem,1997.244(2):p.328-39. 54. Ayala, A., et al., Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and-6 and tumor necrosis factor). Circ Shock,1992.36(3):p.191-9. 55. Cohen, J., The immunopathogenesis of sepsis. Nature,2002.420(6917):p. 885-91. 56. Titheradge, M.A., Nitric oxide in septic shock. Biochim Biophys Acta,1999. 1411(2-3):p.437-55. 57. Beckman, J.S. and W.H. Koppenol, Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol,1996.271(5 Pt 1):p. C1424-37. 58. Feron, O., et al., Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem,1996.271(37):p.22810-4. 59. Connelly, L., M. Madhani, and A.J. Hobbs, Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice:a pro-inflammatory role for eNOS-derived no in vivo. J Biol Chem,2005.280(11):p.10040-6. 60. Wang, X.M., et al., Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway. Am J Respir Cell Mol Biol, 2006.34(4):p.434-42. 61. Wang, X.M., et al., The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol,2009.182(6):p.3809-18. 62. Su, G.L., Lipopolysaccharides in liver injury:molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol,2002.283(2): p. G256-65. 63. Uesugi, T., et al., Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology,2001.34(1):p.101-8. 64. Li, J., et al., Impaired phagocytosis in caveolin-1 deficient macrophages. Cell Cycle,2005.4(11):p.1599-607. 65. Sukumaran, S.K., M.J. Quon, and N.V. Prasadarao, Escherichia coli Kl internalization via caveolae requires caveolin-1 and protein kinase Calpha interaction in human brain microvascular endothelial cells. J Biol Chem,2002. 277(52):p.50716-24. 66. Cohen, A.W., et al., Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am J Physiol Cell Physiol,2003.284(2):p. C457-74. 67. Zhao, X., et al., Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells. Biochem Biophys Res Commun,2009.378(1): p.21-6. 68. Zhang, M., et al., Deletion of caveolin-1 protects hyperoxia-induced apoptosis via survivin-mediated pathways. Am J Physiol Lung Cell Mol Physiol,2009. 297(5):p. L945-53. 69. Volonte, D., et al., Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis. Am J Physiol Heart Circ Physiol,2008.294(1): p. H392-401. 70. Hotchkiss, R.S. and D.W. Nicholson, Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol,2006.6(11):p.813-22. 71. Pinheiro da Silva, F. and V. Nizet, Cell death during sepsis:integration of disintegration in the inflammatory response to overwhelming infection. Apoptosis,2009.14(4):p.509-21. 72. Ayala, A., et al., Apoptosis in sepsis:mechanisms, clinical impact and potential therapeutic targets. Curr Pharm Des,2008.14(19):p.1853-9. 73. Kim, K.D., et al., Adaptive immune cells temper initial innate responses. Nat Med,2007.13(10):p.1248-52. 74. Zhao, J., et al., Do adaptive immune cells suppress or activate innate immunity? Trends Immunol,2009.30(1):p.8-12. 75. Obeid, L.M., et al., Programmed cell death induced by ceramide. Science, 1993.259(5102):p.1769-71. 76. Lalor, D., P. Liu, and J. Hayashi, Fas ligand is enriched in the caveolae membrane domains of thymic epithelial cells. Cell Immunol,2004.230(1):p. 10-6. 77. Ko, Y.G., et al., TNF-alpha-mediated apoptosis is initiated in caveolae-like domains. J Immunol,1999.162(12):p.7217-23. 1. Bone, R.C., The pathogenesis of sepsis. Ann Intern Med,1991.115(6):p. 457-69. 2. Angus, D.C., et al., Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med, 2001.29(7):p.1303-10. 3. Martin, GS., et al., The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med,2003.348(16):p.1546-54. 4. Riedemann, N.C., R.F. Guo, and P.A. Ward, The enigma of sepsis. J Clin Invest,2003.112(4):p.460-7. 5. Sessler, C.N., J.C. Perry, and K.L. Varney, Management of severe sepsis and septic shock. Curr Opin Crit Care,2004.10(5):p.354-63. 6. Brown, M.S. and J.L. Goldstein, Expression of the familial hypercholesterolemia gene in heterozygotes:mechanism for a dominant disorder in man. Science,1974.185(4145):p.61-3. 7. Acton, S., et al., Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science,1996.271(5248):p.518-20. 8. 孙红,陈琪,清道夫受体B类I型的细胞生物学和功能研究医学综述,2007.13(20):p.1534-1536. 9. Krieger, M., Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems. J Clin Invest,2001.108(6):p. 793-7. 10. Chinetti, G., et al., CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. Circulation,2000.101(20):p.2411-7. 11. Krieger, M., Charting the fate of the "good cholesterol":identification and characterization of the high-density lipoprotein receptor SR-BI. Annu Rev Biochem,1999.68:p.523-58. 12. Temel, R.E., J.S. Parks, and D.L. Williams, Enhancement of scavenger receptor class B type I-mediated selective cholesteiyl ester uptake from apoA-I(-/-) high density lipoprotein (HDL) by apolipoprotein A-I requires HDL reorganization by lecithin cholesterol acyltransferase. J Biol Chem,2003. 278(7):p.4792-9. 13. Kozarsky, K.F., et al.. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature,1997.387(6631):p.414-7. 14. Rigotti, A., et al., A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci U S A,1997.94(23):p. 12610-5. 15. Kraemer, F.B., Adrenal cholesterol utilization. Mol Cell Endocrinol,2007. 265-266:p.42-5. 16. Arai, T., et al., Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene. J Biol Chem,1999.274(4):p.2366-71. 17. Braun, A., et al., Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Circ Res,2002.90(3):p.270-6. 18. Kozarsky, K.F., et al., Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse. Arterioscler Thromb Vasc Biol,2000.20(3):p. 721-7. 19. Yu, H., et al., Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class B1 double-knockout mice. Arterioscler Thromb Vase Biol,2006.26(1):p.150-6. 20. Van Eck, M., et al., Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver. J Biol Chem, 2003.278(26):p.23699-705. 21. Cai, L., et al., SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance. J Clin Invest,2008.118(1): p.364-75. 22. Guo, L., et al., Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response. J Biol Chem,2009.284(30):p. 19826-34. 23. Yuhanna, I.S., et al., High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nat Med,2001.7(7):p. 853-7. 24. Li, X.A., et al., High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner. J Biol Chem,2002.277(13):p.11058-63. 25. Mineo, C., et al., High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases. J Biol Chem,2003. 278(11):p.9142-9. 26. Gong, M., et al., HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI-dependent manner. J Clin Invest,2003.111(10): p.1579-87. 27. Li, X.A., et al., Scavenger receptor BI prevents nitric oxide-induced cytotoxicity and endotoxin-induced death. Circ Res,2006.98(7):p. e60-5. 28. Li, X.A., et al., A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type I and suppressed by endothelial nitric-oxide synthase and high density lipoprotein. J Biol Chem,2005.280(19):p. 19087-96. 29. Feng, H., et al., Deficiency of calcium and magnesium induces apoptosis via scavenger receptor BI. Life Sci,2011. 30. Covey, S.D., et al., Scavenger receptor class B type I-mediated protection against atherosclerosis in LDL receptor-negative mice involves its expression in bone marrow-derived cells. Arterioscler Thromb Vase Biol,2003.23(9):p. 1589-94. 31. Zhang, W., et al., Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation,2003.108(18):p.2258-63. 32. Van Eck, M., et al., Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development. Am J Pathol, 2004.165(3):p.785-94. 33. Vishnyakova, T.G., et al., CLA-1 and its splicing variant CLA-2 mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells. Proc Natl Acad Sci U S A,2006.103(45):p.16888-93. 34. Eskandari, M.K., et al., Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia. J Immunol, 1992.148(9):p.2724-30. 35. Wesche-Soldato, D.E., et al., In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood,2005.106(7):p.2295-301. 36. Berwin, B., et al., Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. EMBO J,2003.22(22): p.6127-36. 37. Steinman, C.R., et al., Domain-directed polymerase chain reaction capable of distinguishing bacterial from host DNA at the single-cell level: characterization of a systematic method to investigate putative bacterial infection in idiopathic disease. Anal Biochem,1997.244(2):p.328-39. 38. Cohen, J., The immunopathogenesis of sepsis. Nature,2002.420(6917):p. 885-91. 39. Titheradge, M.A., Nitric oxide in septic shock. Biochim Biophys Acta,1999. 1411(2-3):p.437-55. 40. Su, G.L., Lipopolysaccharides in liver injury:molecular mechanisms of Kupffer cell activation..Am J Physiol Gastrointest Liver Physiol,2002.283(2): p. G256-65. 41. Uesugi, T., et al., Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology,2001.34(1):p.101-8. 42. Poltorak, A., et al., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice:mutations in Tlr4 gene. Science,1998.282(5396):p.2085-8. 43. Raetz, C.R. and C. Whitfield, Lipopolysaccharide endotoxins. Annu Rev Biochem,2002.71:p.635-700. 44. Carmody, R.J. and Y.H. Chen, Nuclear factor-kappaB:activation and regulation during toll-like receptor signaling. Cell Mol Immunol,2007.4(1): p.31-41. 45. Ulevitch, R.J., A.R. Johnston, and D.B. Weinstein, New function for high density lipoproteins. Their participation in intravascular reactions of bacterial lipopolysaccharides. J Clin Invest,1979.64(5):p.1516-24. 46. Ulevitch, R.J., A.R. Johnston, and D.B. Weinstein, New function for high density lipoproteins. Isolation and characterization of a bacterial lipopolysaccharide-high density lipoprotein complex formed in rabbit plasma. J Clin Invest,1981.67(3):p.827-37. 47. Vishnyakova, T.G., et al., Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1. J Biol Chem, 2003.278(25):p.22771-80. 48. Hoekstra, M., et al., Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting. J Lipid Res,2008.49(4):p.738-45. 49. Letourneau, I., et al., Acute renal failure in bone marrow transplant patients admitted to the intensive care unit. Nephron,2002.90(4):p.408-12. 50. Michelsen, K.S., et al., Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A,2004.101(29):p. 10679-84. [series] => [fund_type] => [create_time] => [research_area] => 老年冠心病的病因研究 [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [高海青;Xiang-An Li]山东大学齐鲁医院干部保健科 [issue] => [email] => fenghong19840728@yahoo.com.cn [datebase] => [degree] => 博士 [name_tutor1] => 高海青;Xiang-An Li [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 100203 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => gao hai qing [scopus_No] => [bulletin_date] => [author_en] => feng hong [job_no] => [volume_label] => 48368 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 脓毒症;;caveolin-1;;B类I型清道夫受体;;炎症;;固有免疫 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => 18753157528 [publisher_ad] => [check_180] => [end_page] => [author_cn] => 冯虹 [researcherID] => [fund_ab] => [department_tutor1] => 山东大学齐鲁医院干部保健科 [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => 博士 [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => 医学院 [title_en] => The Roles of Caveolin-1 and Scavenger Receptor BI in Sepsis [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => sepsis;caveolin-1;scavenger receptor BI;inflammation;innate immunity [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => R459.7 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [jl_keyword_en] => scavengerreceptorbi,sepsis,innateimmunity,inflammation,caveolin1 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => 脓毒症,固有免疫,scavengerreceptorbi,sepsis,b类i型清道夫受体,炎症,inflammation,caveolin1,innateimmunity [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [format_student_No_degree_title_cn] => 94b3f9f275588daa148a0678698f226d-386146159 [hints] => 3 [id] => 5Ktr32YBFjIhTVEbVJcv [tags] => 0 ) [2] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 在大规模复杂的现代生产系统中,如何经营管理、组织生产成为决策者关注的重点。车间调度是生产调度的重要组成部分,合理的车间调度不仅可以提高生产效率,降低生产成本,还可以为车间外部的活动计划提供准确的相关信息。对车间调度的研究成果不仅可以指导实际生产,还可以推广到其他涉及资源分配的领域。因此,对车间调度问题的研究具有重大的理论意义和现实意义。 混合流水车间调度问题是一类重要的车间调度问题,在实际生产中有广泛的应用,尤其是在制造业和装配业,因此一直是生产管理者和调度理论研究者关注的重点。约束理论指出,为了减少随机波动对生产的影响,实际生产线应设计为不均衡的。为了使研究接近生产实际,本课题研究加工负荷不均衡的混合流水车间(Hybrid Flow Shop with Unbalanced Workload, HFSUW)调度问题。本课题主要做了以下两方面工作: (1)确定环境下的HFSUW调度。分析了HFSUW车间的特点,利用分解协调调度方法进行调度。根据车间中各阶段的加工负荷及各阶段在工艺路径中的位置,将HFSUW分解为上游非瓶颈阶段、瓶颈阶段和下游非瓶颈阶段。首先松弛上游非瓶颈阶段机器的加工能力,对瓶颈阶段进行调度。然后根据瓶颈阶段的调度结果,将瓶颈阶段和上游非瓶颈阶段协调调度。最后,调度下游非瓶颈阶段。仿真结果表明,分解协调调度算法在求解HFSUW调度问题时,在与下界的平均偏离量和最大偏离量两方而具有一定优越性。 (2)随机机器故障下的HFSUW预测调度。将确定环境下的HFSUW调度作为初始调度,分析随机机器故障发生的位置对初始调度的影响。令故障分别发生在上游非瓶颈阶段、瓶颈阶段和下游非瓶颈阶段,考察故障发生在不同阶段对调度产生的影响。当故障发生后,采用右移重调度方法对未加工工件进行重调度。仿真实验表明,发生在瓶颈阶段的机器故障对调度性能指标的影响最大。为了减小发生在瓶颈阶段的机器故障产生的影响,采用插入空闲时间法生成HFSUW预测调度。为了考察插入的空闲时间长度和位置对预测调度的影响,设计了三种空闲时间插入法。预测调度的预测性是通过工件的计划完成时间和实际完成时间的绝对偏离的平均值来度量的。仿真实验表明,当机器故障发生在工件加工序列前三分之二位置时,三种预测调度虽然牺牲了部分性能指标,但是对机器故障都具有很好的预测性。综合考虑预测调度的效率指标和预测性指标,在瓶颈阶段插入与排序无关空闲时间所产生的预测调度优于其他的预测调度。 [keyword_plu] => [book_alias] => 1011223042.pdf [controlled_terms] => [complete_time] => 2011-05-22 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-22 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 控制理论与控制工程 [cauthor_ad] => [cscd_No] => [abstract_en] => In the large-scale complex modern production system, how to make management decisions and organize production has become decision-makers' major concern. Shop scheduling is an important component of production scheduling. Effective production scheduling can improve the production efficiency, save production costs and provide information for planning external activities. The studies of shop scheduling are not only to guide actual production but also to extend other areas related to resource allocation. Therefore, the research of production scheduling problem has important theoretical significance as well as great practical meaning. Hybrid flow shop scheduling problem is one of the most important scheduling problems. Due to its important engineering applications, especially in manufacturing industry and assembly industry, it has been the focus of production managers and researches. The theory of constraints indicates that the unbalanced capacity of production line should be designed in order to minimize the adverse impact of stochastic fluctuation. To approach the actual production, this paper discusses hybrid flow shop with unbalance workload (HFSUW) scheduling problem. The main research work lies in two aspects as follows. The deterministic HFSUW scheduling problem. According to the feature of HFSUW, a decomposition-coordination method is used for scheduling. HFSUW is decomposed into upstream non-bottleneck stages, bottleneck stage and downstream non-bottleneck stages. Firstly, the capacity of machines in upstream non-bottleneck stages is relaxed and bottleneck stage schedule is obtained. Secondly, based on the schedule of bottleneck stage, upstream non-bottleneck stages are scheduled coordinately. Thirdly, downstream non-bottleneck stages are scheduled. The performance of schedule is measured by the relative deviation between the makespan and the lower bound. The simulation results show that when the capacity is unbalanced, both the average deviation from the lower bound and the largest deviation from the lower bound obtained by decomposition-coordination algorithm are small comparing with other algorithms. Predictable scheduling of HFSUW subject to random breakdown. The schedule obtained by decomposition-coordination method is served as initial schedule. The effect of random machine breakdown occurred on upstream non-bottleneck stage, bottleneck stage and downstream non-bottleneck stage is analyzed respectively. When the execution procedure is subject to a machine breakdown, right shift rescheduling is used to absorb the breakdown. The computational experiments reveal that the breakdown occurred on bottleneck stage has the most impact on efficiency performance. To deal with the breakdown occurred on bottleneck stage of HFSUW, predictable schedule is obtained by inserting additional idle time, which can absorb the effect of breakdown. To examine the influence of the amount and position of additional idle time inserted in predictable schedule, three inserted additional idle time methods are presented. The predictability of predictable schedule is measured by the average absolute deviation between the planned completion time and the realized completion time. Extensive simulation results show that when the breakdown occurred on the two-thirds of job sequence, predictable schedules can provide high predictability with minor sacrificed efficiency performance. Compared with the efficiency performance and the predictability of predictable schedule simultaneously, the predictable schedule obtained by inserting sequence-independent additional idle time at bottleneck stage is better than others. 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[series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [刘海] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 刘海 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 81101 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 51009 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => HFSUW;;分解协调调度;;随机机器故障;;预测调度;;效果分析 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 刘萍萍 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => Hybrid Flow Shop Scheduling Problem with Unbalanced Workload [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => TB497;TP18 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => hfsuw,预测调度,分解协调调度,随机机器故障,效果分析 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 4 [id] => Hatq32YBFjIhTVEb-Y08 [tags] => 0 ) [3] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 在当代西方知识论中,怀疑主义问题广泛受到关注,许多重要的哲学家对此进行了深入的思考和探讨。为了寻求反驳怀疑主义的方法,本文从笛卡尔式怀疑论的基本思想入手,首先分析笛卡尔的两种怀疑论论证和缸中之脑怀疑论论证,其中笛卡尔的两种怀疑论论证为做梦论证和恶魔论证,缸中之脑怀疑论论证则是笛卡尔式怀疑论的现代版;随后笔者提出了三种可能的反驳方法,并且依次对其进行可行性分析。 本文第二部分讨论语境主义理论对于怀疑主义的反驳。首先详细分析了语境主义理论的基本思想,主要涉及到柯亨(Stewart Cohen)与德娄斯(Keith DeRose)的语境主义理论。但是二者的语境主义理论在知识说明上有很大的不同:德娄斯注重知识的定义,而柯亨则是更重视“辩护”这个概念;这种不同使得他们所面对的怀疑主义问题也不同:德娄斯的问题是“我们能否拥有我们的日常知识”,而柯亨的问题则是“我们能否充分的为我们的日常信念辩护”。因此,为了选择更合适的反驳怀疑主义的道路,本文考察了知识的传统分析以及葛梯尔对这个传统分析的挑战,并且得出结论:“辩护”这个概念对于知识的说明具有非常重要的意义;由此,本文倾向于柯亨的语境主义理论。接着本文具体分析了“辩护”概念在语境主义与怀疑主义的论争中的角色,从而凸显了怀疑主义者所提出的“完全辩护”问题。那么语境主义者如何回应“完全辩护”问题呢?语境主义者认为对于信念的辩护要与“语境”概念相关联,但是这远远不足以反驳怀疑主义,而“闭合原则”则是一个很好的突破口。许多语境主义者以否定闭合原则的普遍有效性的代价来反驳怀疑主义,但是这种代价太高了,实际上本文分析得出:语境主义者不需要否定闭合原则的普遍有效性也可以很好的达到目的。但是仅仅分析闭合原则并没有解决怀疑主义问题,因为语境主义者还要说明相关性问题,而这一点对于反驳怀疑主义来说是十分重要的,因此在这一部分的最后,本文详细讨论了这个问题。 本文第三部分讨论关于语境主义理论的反思和发展。首要的问题是:语境主义理论是否反驳了怀疑论?综合文章的讨论,在消除怀疑主义对我们的日常生活所产生的负面影响的意义上,语境主义理论确实反驳了怀疑主义。但是这同时使得语境主义理论面临另外一个批评,即语境主义理论可能具有知识相对主义倾向,而这种倾向是我们难以接受的。因此语境主义理论的发展不仅要与怀疑主义思想进行斗争,而且还要避免倾向于知识的相对主义。 [keyword_plu] => [book_alias] => 1011223730.pdf [controlled_terms] => [complete_time] => 2011-04-10 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 外国哲学 [cauthor_ad] => [cscd_No] => [abstract_en] => In contemporary Epistemology, the problem of Skepticism is very important, many famous philosopher have penetratingly explored on it. The first part is to analyze the basic idea of Cartesian Skepticism, this part including"The Dream Argument", "The Evil Demon Argument"and"Brains-in-a-vat Argument", the Brains-in-a-vat Argument is the modern vision of Cartesian Skepticism. Then I introduce three possible ways to solve the skeptical problem, and analyze the feasibility of these ways. The second part is analyze the Contextualism. First I analyze the basic idea of Contextualism, which is mainly involves the Stewart Cohen's and Keith DeRose's theory. But the two theory are very different on the Epistemolgy:DeRose emphasizes the definition of knowledge, and Cohen emphasizes the notion of "justification", so they need to solve different problems. DeRose's problem is "Can we possess the our daily knowledge", Cohen's problem is "Can we have a sufficient justification on our daily belief". Then I introduce the JTB analysis of knowledge and the Gettier problem to chose the better way to solve the skeptical problem, and arrive at a conclusion that the notion of "justification" is very important to the analysis of knowledge. So, I incline toward Cohen's theory. And then I analyze the position of the notion of "justification" in the solution of skeptical problem, therefore highlight the problem of "Global justification". For solving the problem of "Global justification", many contextualists think that the the justification of belief should be closely related to the notion of "context", but that is far from enough. There is a breakthrough points in the account of "Closure Principle", and many contextualists deny "Closure Principle" to solve the skeptical problem. But this method is costly. In my opinion, the contextualists need not to deny the "Closure Principle". The solution of "relevance problem" is also necessary, which is discussed in detail. The third part analyze the reflection and development of the theory of Contextualism. The first question is:"Has Contextualism solved the problem of Skepticism?". According to the above analysis, in the sense of reducing the negative influence of Skepticism which has an adverse effect on our daily life, Contextualism has solved the Skeptical problem. But another difficulty arises here:Contextualism could have a tendency of Relativism in solving the Skeptical problem. This criticism is unacceptable. So, in my opinion, in the future development of Contextualism, Contextualism need not only to fight against Skepticism, but also to avoid the tendency of Relativism. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => [page] => 63 [title_cn] => 语境主义理论能否走出怀疑论困境 [article_dt] => [name_editor] => [reference] => ①曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社,前言,第1页。 ②徐向东:《怀疑论、知识与辩护》,北京大学出版社,第26页。 ①Duncan Pritchard:"Recent Work On Radical Skepticism", in American Philosophical Quarterly Volume 39, Number 3, July 2002, p.215. ②陈嘉明:《知识与确证——当代知识论引论》,上海人民出版社2003年版,第251页。 ③Duncan Pritchard:"Recent Work On Radical Skepticism", in American Philosophical Quarterly Volume 39, Number 3, July 2002, p.215. ④曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,前言,第216页。 ⑤Duncan Pritchard:"Recent Work On Radical Skepticism", in American Philosophical Quarterly Volume 39, Number 3, July 2002, p.229. ①曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,前言,第244-245页。 ②Duncan Pritchard:"Recent Work On Radical Skepticism", in American Philosophical Quarterly Volume 39, Number 3, July 2002, pp.228-229. ③陈嘉明:《知识与确证——当代知识论引论》,上海人民出版社2003年版,第13页。 ④陈嘉明:《知识与确证——当代知识论引论》,上海人民出版社2003年版,第14页。 ①曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社,前言,第195页。 ②Duncan Pritchard:"Recent Work On Radical Skepticism", in American Philosophical Quarterly Volume 39, Number 3, July 2002, p.229. ③阳建国:《步步为营的语境主义——论斯图尔特·科恩的反怀疑论方案》,《哲学动态》2008年第1期。 ④王荣江:《知识论的当代发展:从一元辩护走向多元理解》,《自然辩证法通讯》2004年第4期。 ⑤程炼:《刘易斯与怀疑论》,《云南大学学报》2004年第6期。 ①程炼:《刘易斯与怀疑论》,《云南大学学报》2004年第6期。 ②曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社,前言,第233页。 ①笛卡尔:《第一哲学沉思集:反驳与答辩》,庞景仁译,商务印书馆1986年版,第11页。 ①笛卡尔:《第一哲学沉思集:反驳与答辩》,庞景仁译,商务印书馆1986年版,第20-21页。 ①徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第220页。 ①转引自曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第216页。 ②曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第217页。 ①曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第217-218页。 ②曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第218页。 ③曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第220页。 ①曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第220-221贝。 ②曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第221页。 ①Stewart Cohen, "Contextualism and Skepticism", Philosophical Issues,2000(10):97. ②转引自曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第220-221页。 ① Stewart Cohen, "Contextualism and Skepticism", Philosophical Issues,2000(10):97. ②转引自曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第218页。 ③曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第218页。 ④曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社2009年版,第244-245页。 ①陈嘉明:《知识与确证——当代知识论引论》,上海人民出版社2003年版,第14页。 ①徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第6-7页。 ①徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第7-8页。 ②徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第208页。 ①徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第28-29页。 ②徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第208页。 ①徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第209页。 ①徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第213页 ①徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第215页。 ②徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第215-216页。 ③David Lewis, "Elusive Knowledge", A Contemporary Reader, Oxford:Oxford University Press,1999, pp.225-229. ①徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第214页。 ②徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第215页。 ①康德:《纯粹理性批判》,邓晓芒译,人民出版社2004年版,第一版序,第2页。 ①Stewart Cohen,"Contextualism and Skepticism",Philosophical Issues,2000(10):100. ②Stewart Cohen,"Contextualism and Skepticism",Philosophical Issues,2000(10):100. ③徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第29-30页。 ①Stewart Cohen, "Contextualism and Skepticism", Philosophical Issues,2000(10):100. ①徐向东:《怀疑论、知识与辩护》,北京大学出版社2006版,第223页。 ②Chris Swoyer, "Relativism", Stanford Encyclopedia of Philosophy. 1.徐向东:《怀疑论、知识与辩护》,北京大学出版社,2006。 2.陈嘉明:《知识与确证——当代知识论引论》,上海人民出版社,2003。 3.陈嘉明:《现代西方哲学方法论讲演录》,广西师范大学出版社,2009。 4.曹剑波:《知识与语境:当代西方知识论对怀疑主义难题的解答》,上海人民出版社,2009。 5.[法]笛卡尔:《第一哲学沉思集:反驳与答辩》,庞景仁译,商务印书馆,1986。 6.[法]笛卡尔:《谈谈方法》,王太庆译,商务印书馆,2000。 7.康德:《纯粹理性批判》,邓晓芒译,人民出版社,2004。 8.金岳霖:《知识论》,中国人民大学出版社,2010。 9.[美]路易斯·P·波伊曼:《知识论导论:我们能知道什么》,洪汉鼎译,中国人民大学出版社,2008。 10.[美]齐硕姆:《知识论》,邹惟远、邹晓蕾译,三联书店,1988。 11.[美]梯利:《西方哲学史》增补修订版,伍德增补,葛力译,商务印书馆,1995。 12.张志伟:《西方哲学史》,中国人民大学出版社,2002。 13.赵敦华:《西方哲学简史》,北京大学出版社,2001。 14.赵敦华:《现代西方哲学新编》,北京大学出版社,2001。 15.叶秀山、王树人总主编:《西方哲学史》,凤凰出版社,2004-2005。 16.[英]罗素:《西方哲学史》,张作成编译,北京出版社,2007。 17.邓晓芒、赵林:《西方哲学史》,高等教育出版社,2005。 18.苗力田、李毓章主编:《西方哲学史新编》,人民出版社,1990。 19.涂纪亮:《现代西方哲学研究:涂纪亮哲学论文选》,社会科学文献出版社,2010。 20.韩秋红、王艳华、庞立生编著:《现代西方哲学概论:从叔本华到罗蒂》,北京大学出版社,2010。 21.张汝伦:《现代西方哲学十五讲》,北京大学出版社,2003。 22.刘放桐:《新编现代西方哲学》,人民出版社,2000。 23.夏基松:《现代西方哲学教程》,上海人民出版社,1985。 24.程炼:《刘易斯与怀疑论》,《云南大学学报》,2004(6)。 25.曹剑波、张立英:《我知道“我不是缸中之脑”吗?》,《自然辩证法研究》2008(4)。 26.曹剑波:《怀疑主义难题的解答》,《哲学动态》,2005(8)。 27.曹剑波:《缸中之脑知道“我不是缸中之脑”吗?》,《自然辩证法通讯》,2006(2)。 28.曹剑波、张立英:《知识论语境主义对怀疑主义难题的解答》,《厦门大学学报(哲社版)》,2007(3)。 29.曹剑波:《葛梯尔反例意义的诘难》,《复旦学报(社科版)》,2004(5)。 30.曹剑波:《闭合论不是重言式——当代西方知识论对怀疑主义的重要论证方式的批判》,《厦门大学学报(哲社版)》,2004(6)。 31.曹剑波:《怀疑主义难题的摩尔式解答》,《南京社会科学》,2006(6)。 32.曹剑波:《怀疑主义难题的语境主义解答——基思·德娄斯的虚拟条件的语境主义评介》,《自然辩证法研究》,2005(6)。 33.曹剑波:《相关选择论——当代知识论对怀疑主义的批判》,《自然辩证法研究》,2004(11)。 34.阳建国:《步步为营的语境主义——论斯图尔特·科恩的反怀疑论方案》,《哲学动态》,2008(1)。 35.王荣江:《知识论的当代发展:从一元辩护走向多元理解》,《自然辩证法通讯》,2004(4)。 36. 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[series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [傅永军] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 傅永军 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 10103 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 50001 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 怀疑主义;;语境主义;;辩护;;语境;;闭合原则;;相关性;;相对主义 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 于明 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => Whether Contextualism Has Solved Skeptical Problem or Not [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => B083 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 5 [id] => _atr32YBFjIhTVEbGJBJ [tags] => 0 ) [4] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 经历金融危机的洗礼之后,国际分工格局进入了重整与再平衡时期,美欧国家经济萧条与市场萎缩,促使各国更多地将注意力转向了经济发展和拥有巨大市场的东亚地区,中日韩三国之间的经济合作与贸易自由化发展成为当前关注的焦点,在此背景下,中日韩三国FTA的构建问题逐步提上日程。农产品贸易是中日韩三国贸易的重要组成部分,日本、韩国已成为我国极为重要的农业经贸伙伴,也是我国农产品出口的两大重要市场,然而由于日韩两国对本国农业以及农产品市场的过度保护,农产品贸易成为中日韩三国FTA建立极具争议的一个方面,因此,在FTA背景下研究中日韩三国农产品贸易将具有十分重要意义。 本文从中日韩三国FTA建立的可行性入手,以统计描述的方法从经济、政治以及地理文化等方面论述了三国FTA建立的可行性,同时对三国FTA建立阻碍因素之一的农业因素进行了分析研究。 接下来对中日韩三国农业政策、农产品贸易政策以及三国农产品贸易的主要特征进行了研究。通过研究,中日韩三国自由贸易具有坚实的现实基础,但也存在诸多的障碍,其中包括农业问题,三国特别是日韩两国若不能妥善处理农业问题,建立三国FTA将面临很大障碍。 然后通过计算中日韩三国显示性比较优势指数(RCA)测算了中日韩三国两两间农产品贸易互补性指数,总体来看,中日、中韩间的农产品贸易互补性要强于日韩间农产品贸易互补性。接着通过选取中日韩三国间2009年农产品贸易排名前10名代表产品价格进行计算对比,可以看出中国农产品价格较日韩两国具有较大优势,建立三国FTA后将有利于中国农产品的出口。 最后为推动中日韩三国FTA建立,促进三国农产品贸易发展,提高中国农产品竞争力,提出了重点发展优势农产品、加快质量标准体系建设以及改善农业贸易发展环境等相关政策建议。 [keyword_plu] => [book_alias] => 1011226830.pdf [controlled_terms] => [complete_time] => 2011-04-15 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-22 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 国际贸易学 [cauthor_ad] => [cscd_No] => [abstract_en] => After the financial crises, the international division of labor has entered into a restructuring and re-balancing period. The economic recession and market contraction in the United States and Europe have prompted more countries to turn their attention to East Asia in which there is quite economic development and a huge market. The economic co-operation and trade liberalization between China, Japan and South Korea has become the current focus of attention. So, the FTA construction between the three countries is being put on the agenda. The agricultural products are the important part of trade between China, Japan and South Korea. Japan and South Korea have become China's most important agricultural trading partners and important markets of China's agricultural exports. However, owing to Japan and South Korea's excessive protection for their own agriculture and agricultural markets, agricultural trade has become a highly controversial aspect in establishing FTA between China, Japan and South Korea. Therefore, the study of the agricultural products trade between China, Japan and South Korea in the context of FTA will be of great significance. The author of this thesis employs the statistical description method to study the feasi-bility of FTA establishment between China, Japan and South Korea from economic, political as well as geographical and cultural aspects. Meanwhile the author made an analytical study of one of the three barriers to FTA establishment--agricultural factor. Then, the author made a study of the agricultural policy, agricultural trade policy and main features of agricultural trade in every country. The findings reveal that the free trade between China, Japan and South Korea has a solid foundation in reality, but there are still many obstacles, among which is agriculture problem. If the three countries, especially Japan and South Korea cannot properly handle the issue of agriculture, the establishment of FTA will be very difficult. Next, by calculating the revealed comparative advantage index (RCA) of China, Japan and South Korea, the author measured the agricultural trade complementarity index between the three pairs. Generally, the agricultural trade complementarity between China and Japan, China and South Korea is stronger than that between Japan and South Korea. Furthermore, the author made a price comparison between the three countries' top 10 products in 2009 agricultural trade ranking, and found that the prices of agricultural products in China have greater advantages than those in Japan and South Korea, and the establishment of FTA will benefit China's exports of agricultural products. Finally, in order to promote the establishment of FTA between China, Japan and South Korea, to promote the agricultural trade between the three countries and enhance the competitiveness of Chinese agricultural products, the author proposes some related policy recommendations such as focusing on the development of competitive agricultural products, speeding up the quality standards system construction and improving the agricultural trade development environment. 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[author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 20206 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 51348 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => FTA;;中日韩;;农产品贸易;;互补性 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 韩伟 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => Study on China-Japan-Korea Agri-product Trade under the FTA Framework [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => F752.7 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => fta,中日韩,互补性,农产品贸易 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 4 [id] => GKtq32YBFjIhTVEb64x3 [tags] => 0 ) [5] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 动机被公认为是影响二语或外语学习成效的重要因素之一。由于绝大多数的二语或外语学习是在语言课堂上进行的,因此在课堂上激发学生学习动机的策略对于语言教师来说至关重要。本文是对大学英语专业教师的课堂动机策略所做的一项调查研究,旨在探究教师对动机策略的观念,教师观念与课堂动机策略使用之间的关系,以及学生对其教师动机策略实际使用的认识。 本调查基于Dornyei & Csizer(1998)的动机策略量表,围绕十项宏观动机策略进行研究。调查数据来自以德州学院五名英语专业教师为样本进行的半结构式访谈和课堂观察,以及对五名教师的学生所做的问卷调查。对教师的访谈主要围绕教师对动机策略的认识,包括对教师行为、课堂环境、任务、师生关系、自信心、兴趣、自主学习、目标、学习团队和语言文化的认识,以及教师课堂动机策略的使用情况两个方面进行。课堂观察主要用于调查教师动机策略在课堂上的实际运用。对学生的问卷调查旨在研究教师动机策略的运用与学生对其认识的一致性。 研究结果显示,教师认为动机策略在教学中起到重要作用。教师经常运用教师行为、师生关系、语言文化、任务、自主学习、自信心、兴趣和课堂环境八项宏观策略,但对目标和学习团队的使用相对较少。研究结果表明,教师对大多数动机策略的重要性均普遍存在共识,仅在教师行为、学习团队和语言文化上存在一定差异。所有教师在课堂上能够运用各种不同的动机策略来激发学生学习动机。除在课堂环境、兴趣、自主学习和目标中存在较小差异外,大多数动机策略的使用与教师的认识基本一致。此外,学生问卷调查的结果表明教师陈述的动机策略使用与学生的认识基本一致。 基于研究结果和发现,本文对教师动机策略的使用提出了十项方针,对大学教师和所在院校提出了一些建议。教师应重新认识并增强其对动机策略的认知和运用,使用多种策略激发学生,加强与学生和同事的之间的交流与合作。学校方面应增加教师培训的机会,并为大学教师提供办公场所以促进各种交流的进行。 [keyword_plu] => [book_alias] => 1011224270.pdf [controlled_terms] => [complete_time] => 2011-03-26 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 英语语言文学 [cauthor_ad] => [cscd_No] => [abstract_en] => Motivation is acknowledged to be one of the important factors influencing the second/foreign language achievements. As most second/foreign language learning is carried out in classrooms, the skills to motivate learners in classrooms are crucial for language teachers. This study investigates the motivational strategies used by college English teachers in the classroom. It aims to explore teachers' beliefs of motivational strategies, the relationship between their beliefs and application of motivational strategies, and students' perception of the actual use. Based on Dornyei & Csizer's (1998) strategy scales, ten categories of motivational strategies were adopted in the study. The data were collected via semi-structured interviews and classroom observations of five college English teachers of Dezhou University, and a questionnaire survey with their students. The interviews of the teachers centered around teachers' beliefs of motivational strategies, including beliefs about teachers' behavior, climate, task, rapport, self-confidence, interest, autonomy, goal, group, and culture, and their application of these strategies in classrooms. Classroom observation was made to examine the participant teachers' actual practice of motivational strategies in classrooms. The investigation of their students aimed to find out the degree of consistency between teachers' reported application of motivational strategies with their students'perception. The results show that teachers highlight the importance of using motivational strategies. Eight categories of motivational strategies are used at high frequency including teachers'behavior, rapport, culture, task, autonomy, self-confidence, interest, and climate, while goal and group are used at middle frequency. The teachers reach a consensus on the importance of most aspects of motivational strategies, and have only slightly different opinions of the effect of teachers' behavior, group and culture. All of them try to use various strategies to motivate students in the classroom, and most of their applications of strategies are consistent with their beliefs, except for a few small gaps in the aspects of climate, interest, autonomy and goal. Moreover, teachers'use of motivational strategies is found to be basically consistent with their students'perception. Based on the study, ten guidelines of motivational strategies are provided and some suggestions are made for both college teachers and administrators. College teachers should also reflect and strengthen their beliefs and application of motivational strategies in classroom, use various motivational strategies and strengthen communication and cooperation with students and colleague teachers. 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[series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [卢敏] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 卢敏 [cauthor_back] => [begin_page] => [publisher] => [language] => 英文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 50201 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 49973 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 动机;;动机策略;;教师观念 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 程福梅 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => Motivational Strategies Used by College English Teachers in Classrooms: A Case Study [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => H319 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 英文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => 动机,动机策略,教师观念 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 3 [id] => qatr32YBFjIhTVEbGJFJ [tags] => 0 ) [6] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 研究背景:本课题旨在研究提高机体缺血缺氧组织对ATP的摄取,制备可方便临床应用的静脉使用或外用的的ATP新剂型;探索一种病灶靶向性高、不良反应少、作用稳定的载药系统。脂质体是目前应用最为广泛、治疗效果最为肯定的载药系统之一,其具有无毒,无免疫原性及良好组织相容性等诸多优点。目前在研究的各种药物载药系统中,只有脂质体已批准应用于临床,其他的纳米载药系统绝大多数仍处于临床前甚至实验室研究阶段。 研究方法:本课题采用大豆磷脂和胆固醇为主要膜材,以ATP为模型药物,通过十八胺来调节脂质体的Zeta电位,采用逆向蒸发法制备ATP脂质体。以包封率为评价指标,采用正交试验优化处方及制备工艺。考察了磷脂浓度、磷脂和胆固醇比、药脂比、水浴温度、旋蒸仪转速等对ATP脂质体包封率的影响,建立了ATP脂质体的含量测定方法及包封率测定方法,并初步研究了ATP脂质体的理化性质、体外释放性质、初步稳定性等,为脂质体制剂的开发应用提供了试验基础和理论依据。 研究结果: 1.ATP脂质体药物含量及包封率测定方法的建立 采用超低温超速离心法将载药脂质体与游离药物分离,并建立了HPLC法测定脂质体中ATP含量及包封率的测定方法。结果:ATP在20-640μg/ml浓度范围内线性关系良好,以峰面积(A)对浓度(C)作线性回归,得回归方程为A=0.1602C+7.3767,r=0.9997。日内、日间精密度RSD均小于2.0%,回收率中高浓度均在98%左右,但低浓度偏离较大,可能与仪器误差有关,日内及日间RSD均小于2%。 2.ATP脂质体的制备工艺、处方研究及脂质体的形态及理化性质 以ATP脂质体的包封率为主要参考指标,将制备温度、磷脂和胆固醇比、药脂比、有机相/水相比例、水浴温度及旋转蒸发仪转速等相关因素做单因素考察分析,在此基础上,采用正交优化设计法对ATP脂质体处方进行考察,选取磷脂浓度、药物脂质质量比、磷脂和胆固醇质量比、旋转蒸发仪转速等为影响因素,以包封率为主要考察指标进行评价,并最终得到了ATP脂质体的优化处方。结果采用优化处方制得的ATP脂质体经在透射电镜下为多囊状的多层的类圆球体,于处方中加入与磷脂质量比为0:1、0.05:1、0.10:1的十八胺,得到的脂质体的Zeta电位分别为2.1±0.4mv、12.3±1.2mv、20.4±2.6mv。 通过固定处方加十八胺(与磷脂质量比为0.05:1)逆向蒸发法制备ATP脂质体,得到脂质体的粒径为810.9nm,多分散系数为0.543。 最后以磷脂浓度为10mg/ml,磷脂与胆固醇质量比为4:1,药脂质量比为1:2,旋蒸仪转速为30r/min,十八胺与磷脂质量比为0.05:1,为最终优化处方制备脂质体,平均包封率分别为(56.99±4.91)%,载药率为(21.81±1.89)%。 3.ATP脂质体的体外释药动力学及初步稳定性研究 采用与人血浆等渗的pH=7.4的磷酸盐缓冲液作为释放介质,其中含137 mmol/L NaCl、3mmol/L KCl、8mmol/L Na2HPO4和1 mmol/LKH2PO4。采用动态透析膜法进行脂质体混悬液中药物的体外释放研究。结果:ATP脂质体的释放曲线方程为:Lnln(1/(1-Q))=0.5871nt-1.656,更为符合weibull释放数学模型。 初步稳定性考察结果表明ATP脂质体4℃贮存15天药物渗漏率达27.74%,因此,为了增加脂质体稳定性,课题计划下一步采用冷冻干燥法将ATP脂质体制备ATP前体脂质体增强稳定性。 结论:本课题成功研制了ATP脂质体制剂,所采用的制备工艺简便可行,重现性好,包封率较高;脂质体作为ATP的载体可以明显增加ATP在体外的稳定性,并极大地拓宽了使用范围;适于注射或外用给药,方便了临床应用等。但是课题研究发现ATP脂质体长时间放置后出现渗漏,而且随着时间的延长,渗漏率也会随之增加,我们计划下一步进行ATP脂质体冻干制剂的研究,以进一步提高ATP脂质体的稳定性。 [keyword_plu] => [book_alias] => 1011223682.pdf [controlled_terms] => [complete_time] => 2011-04-24 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-19 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 临床医学 [cauthor_ad] => [cscd_No] => [abstract_en] => Background:The project aims to study how to improve the intake of ATP in the state of tissue ischemia and hypoxia, and prepars the new formulation which is intravenous or external use for clinical application; explore a high bioavailability, low toxicity and stability drug delivery systems. Liposome is the most important and most widely used nano-drug delivery systems in the world, which is non-toxic, non-immunogenicity, and good tissue compatibility, it can improve the bioavailability of drugs, and enhance the organ targeting. At present, only the liposome dilivery system is used in clinical,and the vast majority of other delivery system are still in pre-clinical research stage. Methods:In the project we choose soybean Phophatidylcholine and cholesterol as the main membrane materials and ATP as a model drug, to regulate Zeta potential of liposomes by octadecylamine.We prepared ATP liposomes in the way of reverse phase evaporation, and optimize the formulation though the orthogonal test in the index of entrapment efficiency. The factors contain phospholipid concentration,phospholipids and cholesterol ratio, drug and lipids ratio, water temperature, spin speed and and so on, we establish the ATP assay method in the liposomes and the method of entrapment efficiency determination, and we also study the physical and chemical properties of ATP liposomes, in vitro release properties, the short-time stability, which provide the experimental and theoretical basis for the development and application of liposomes. Results: 1. Establishment of the ATP assay method and liposome encapsulation efficency method. The liposomes and free drug are separated by high speed centrifugation.and the entrapment effieieney and drug concentration were determined by the method of HPLC. Results:There was a good linearity of the drug concentration with in the range of 20-640ug/ml and the linear equation was A= 0.1602C+7.3767, r=0.9997. The recovery rate was more than 98% in the middle and high concentration,but there is large deviations in the low concentration, which may be related to instrumental error, and all of the RSD (intra-and inter-day) were less than 2.0%. 2. Preparation of ATP liposomes, and the physical and chemical properties With the encapsulation efficiency as judgment index. The effects of various factors on entrapment efficiency were investigated by single factor and orthogonal experients. The factors contain phospholipid concentration,phospholipids and cholesterol ratio, drug and lipids ratio, water temperature, spin speed and and so on.The ATP liposome obtained after optimized prescription was multi-layer balls cystic body in the transmission electron microscopy.We regulate the zeta potential of liposomes by octadecylamine,and phospholipids and cholesterol in a fixed prescription,change the amount of octadecylamine added in the formulation at a ratio of 0:1,0.05:1,0.10:1 to lipids,the zeta potential was 2.1±0.4mv,12.3±L2mv,20.4±2.6mv.At a ratio of 0.05to l,the ATP liposome diameter we obtained is 810.9nm,and the polydispersity is 0.543. The optimized fotmulation is as follows:the phospholipid concentration of 10mg/ml, phospholipids and cholesterol mass ratio of 4:1, lipid and drug ratio is 1:2, the speed of rotary evaporator is 30r/min, octadecylamine and phospholipid mass ratio is 0.05:1, the average encapsulation efficiency in this formulation is (56.99±4.91)%, drug loading rate is (21.81±1.89)%. 3. The release kinetics of ATP liposomes in vitro and the short-time stability. We use the pH= 7.4 phosphate buffer isotonic with human plasma as the release medium, which contains 137 mmol/L NaCl,3 mmol/L KC1,8 mmol/L Na2HPO4, and 1 mmol/L KH2PO4. The in vitro release of ATP from the medium were evaluated using the dialysis bag diffusion technique.ATP-loaded liposomes all presented controlled release properties, and nonlinear fits of ATP release from liposomes was modeled. The in vitro release behavior of ATP from liposomes could be described by Weibull kineties model and expressed by the following equations:Lnln (1/(1-Q))= 0.5871nt-1.656. The stability results show that the leakage rate of ATP liposomes is 27.74% at 4℃storage for 15 days, therefore, in order to increase the stability of liposome we can transfer ATP liposome into ATP proliposomes by using freeze-drying method next step. Conclutions:This project developes a liposome with high encapsulation efficiency successfully, and the processing technology is simple, feasible and reproducible; liposomes as carrier of ATP can significantly increase the half-life of ATP in vitro; are conducive to injection or topical administration and facilitate the clinical application.At the same time, this study finds that with the time goes, the leakage rate of ATP liposome increases, the next step we must solve is to further improve the stability of liposomes, so the lyophilized ATP liposomes study is needed. 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[series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [高海青;邱洁] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 高海青;邱洁 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 100702 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 49907 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => ATP;;脂质体;;逆向蒸发法;;体外释放;;包封率;;载药量 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 刘勇 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => The Preparation and Studies of Adenosine Triphosphate-loaded Liposomes [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => R944.9 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => 载药量,atp,包封率,体外释放,逆向蒸发法,脂质体 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 4 [id] => Z6tr32YBFjIhTVEbGJFJ [tags] => 0 ) [7] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 现在的媒体越来越多地对自然灾害、人为事故、车祸等所导致人员伤亡事件进行高密度、多角度的播报、解读和分析,因而,消费者对事情的起因、经过和人员的伤亡情况有了更为深入的了解和感受。但是,该类事件大范围、高密度播报会产生另一效果——即,消费者会产生生命有限性的认知和生命结束的突然性的感觉。随着媒体中造成人员伤亡的事件的类型的增多,消费者的这类感觉会越来越强烈。另外,随着生活水平的提高,人们现在越来越重视自身的价值和生命价值的可持续性,并且,也通过养生、健身等方式来延长生命的价值。当这两种相互矛盾的事件相互碰撞时会使消费者产生恐惧和焦虑心理,并对消费者的消费行为产生一定程度的影响。 用何种理论去分析消恐惧和焦虑心理影响下的消费者行为一直是消费者行为研究领域的学者们的研究重点。那么,在对由与死亡相关的媒体语境所激发的生命有限性认知和生命结束的突然性的感觉而产生恐慌和焦虑进行心理防御过程中,消费者在购买商品的过程中是否会对中外品牌产生差异性的选择行为呢? 基于该领域研究中常用到的恐惧管理理论,本文对该问题进行了深入的探讨和分析。通过设置三种实验情景,分别研究了涉及到人员伤亡的媒体语境是否会增强消费者对国内品牌的选择;在这种影响过程中,恐惧管理理论所强调的文化价值观(文中以消费者的爱国情操为例)是否发挥了调节作用;当媒体资讯中所播报的人员伤亡的事件发生地不同时(如分别发生在国内和国外)涉及到人员伤亡的媒体语境在影响消费者品牌选择过程中是否会产生差异性的影响效果;最后,当消费者接触到有关人员伤亡的媒体资讯和其进行品牌选择过程中存在时间距离时,消费者对中外品牌的选择是否会有差异。本文基于实验要求,以烟威青和济南高校自习室中上自习的学生为实验对象,通过让被试阅读实验材料刺激起他们对生命有限性的认知,然后让被试回答一系列的问卷来收集相关的数据。通过分析发现,消费者在受到有关人员伤亡的媒体语境的刺激后,对国内品牌的确有着更强的选择趋势,并且在媒体语境和对国内品牌的选择过程中,消费者的文化价值观(爱国情操)起着调节作用。当媒体播报中所涉及到的人员伤亡的事件的发生地不同时,消费者在对国内品牌的购买欲望和将国内品牌列为首选方面也表现出差异,从而说明人员伤亡的发生地不同会使消费者选择中外品牌方面产生明显的差异。另外,无论消费者接触到有关人员伤亡的媒体语境和选择中外品牌之间是否存在着时间距离时,消费者对国内品牌的选择不存在明显的差异。本文的研究成果为国内学者运用恐惧管理理论来研究消费者行为又提供了一个理论基础,从而在理论上作出了一定的贡献,同时为营销实践者的实践活动提供了理论指导。 [keyword_plu] => [book_alias] => 1011224115.pdf [controlled_terms] => [complete_time] => 2011-05-14 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-14 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 企业管理 [cauthor_ad] => [cscd_No] => [abstract_en] => Mass media is satiated with an increasing amount of death-related content. For example, more and more people lose their life in the disasters, accidents and so on.However,the reports of such events can prime the concept of death, and make people feel anxiety and panic, and render their behaviors definitely. Researchers on the consumer behavior domain have argued for a long time in the choice of theories which will be used to analyse the consumer behavior in such media context. On the other way, does it exist differences between the choice of domestic and overseas brands when people feel anxiety and panic in the media context satiated with mortality. Based on the framework of terror management theory,this paper answer the above question by analyzing some data collected from the laboratory.Through setting up three scenes, we demonstrate the influence of death-related media context on the choice of domestic brand, the accommodation of cultural worldview in the process of influence, and the difference between the consumers' choice of domestic and foreign brands when we change the scene where people died or insert or remove the time control material.Owing to the principle of the experiment,the people reviewing their lessons in the schoolroom in Yantai,Weihai,Tsingtao and Jinan were invited to the experiment.The death concept was stimulated by reading materials provided in the lab,and then the participants were requested to answer a series of questionnaire to measure their patriotism and their choice between the domestic and foreign brands. By analyzing the data, we can find that the death-related media context can promote the choice of domestic brands and the patriotism does mediate the relation of media context and the consumers' brand choice in the process. When the participants were divided into two parts by the site of the incident, we can see that difference exists between the two parts. However, we didn't get difference when the participants were divided into two parts based on the time distance control.The result remdies the margin in the use of terror management theory and can conduct the marketers to serve the consumers and get more benefit. 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The Moderator-Mediator Variable Distinction in Social Psychological Research:Conceptual, Strategic,and Statistical Considerations[J].Journal of Personality and Social Psychology.51(6):1173—82 [35]Greenberg, Jeff,Tom Pyszczynski,Sheldon Solomon,Linda Simon and Michael Breus.1994.Role of Consciousness and Accessibility of Death-related Thoughts in Mortality Salience Effects [J].Journal of Personality and Social Psychology.67(4):627-37 [36]Watson,David,Lee A.Clark,and Auke Tellegen.1988.Development and Validation of Brief Measuers of Positive and Negative Affect:The PANAS Scales[J].Journal of Personality and Social Psychology.53(june):1063-1070 [series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [董昭江] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 董昭江 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 120202 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 50182 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 恐惧管理理论;;媒体语境;;爱国情操;;时间距离;;品牌选择 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 李卿云 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => The Effect of Media Contexts on Consumers' Brand Choice [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => F274;F224 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => 媒体语境,时间距离,爱国情操,恐惧管理理论,品牌选择 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 5 [id] => 6qtr32YBFjIhTVEbB5Cs [tags] => 0 ) [8] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 为建立适应社会主义市场经济要求的新的城镇住房制度,形成稳定的住房资金来源,促进职工解决资金的积累、周转和政策性贷款制度的建立,转换住房分配机制,提高职工解决自住住房能力,建立住房公积金制度。随着管理要求的不断提高,目前运行的系统已无法满足业务开展,风险控制无法满足,数据安全、资金安全得不到保证,因此也成为影响中心发展的瓶颈。为进一步巩固和加强住房公积金管理,要加强网络安全系统建设,制定应急和灾备预案,建立数据的即时备份和异地备份制度,确保系统和数据安全,确保住房公积金管理安全、稳定、持续、健康发展,最终实现“统一决策、统一制度、统一管理、统一核算”的管理目标,使“管理信息化,信息资源化,资源社会化”的成为可能,因此必须重新建立一套以财务核算为核心、风险可控以及服务渠道化的综合业务系统,加强对全市的住房公积金机构的监管力度和调控水平,降低管理成本和经营风险,实现公积金的保障和增值效益,意义重大。 本系统建设的核心内容是实现“潍坊市住房公积金管理信息系统”(以下简称住房公积金管理系统),由于本系统纵向上与部省住房公积金监管,横向上与人行征信都有着紧密的结合,因此我们在进行本系统的整体架构设计时既考虑到住房公积金的实际需要,又要充分考虑系统的可扩展性和通用数据接口,从而勾画出本项目的软件架构设计。 通过对目前几种比较常用的计算机体系结构进行分析比较,同时结合公积金业务管理系统的具体要求与应用特点,最后选定基于J2EE开发平台,集成工作流引擎、交易中间件来搭建系统的基本框架。这种体系结构的设计将系统展现层、控制层、业务层合理解耦,具有清晰的层级关系、完善的权限管理体系、完备的日志记录功能、可靠的数据校验纠错控制、强大的网络及硬件测控、系统容错、备份恢复等安全机制,满足公积金中心目前和未来的业务需求,在系统整体架构、业务流程构造以及数据分析和决策支持等方面均能达到先进水平。 [keyword_plu] => [book_alias] => 1011227867.pdf [controlled_terms] => [complete_time] => 2011-04-20 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-29 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 软件工程 [cauthor_ad] => [cscd_No] => [abstract_en] => To establish a socialist market economy require to the new urban housing system and to form a steady source of funds for housing, the solution to the fund accumulated, the working capital loans system and policy, the housing allocation mechanism to improve staff in the ability to solve the housing and housing provident fund system. Housing provident fund is a long-term housing his savings in staff work, workers and the unit shall be in the wages and the wages of the proportion paid monthly to the all, as the housing fund and special deposit storage and unified management and special use. with administrative requirements of the continuous improvement, running system has been unable to meet the business and risk control was unable to meet and data security, money without security. Therefore also affect the centre of development bottlenecks. To further consolidate and strengthen the housing provident fund administration, we must strengthen the network security system development, formulation of contingency and plagues establish a data backups and place as a backup system, ensure that the system and data security, Ensure that housing provident fund administration security, stability, sustained and healthy development and "reunification of the unified system of decision-making, management accounting, unity and reunification of the regulatory goals," the management of information, information and socialized resources, Therefore essential to establish a financial accounting for the core, risk may be charged with, and service channel of general business systems, housing provident fund to strengthen the supervision and regulation of the efforts to reduce administrative costs and risks, the implementation of security and efficiency of fund, the value of great importance. So we make this system of overall architecture design is considering the actual needs in the housing provident fund, we must fully consider the system include extensibility and data to sketch the project software architecture. Through have a few more common computer architectures for analysis and comparison, the combined fund management system and application of specific requirements, and finally selected based on the development platform j2ee, integrated workflow engine, middleware to build the basic framework. The architectural design the system display, control, the business layer, together with a clear understanding layer, to improve the competence of management system and complete the logging functional, reliable data and correct mistakes to control the checksum, a strong network and hardware, fault-tolerant tracking control system, the backup to restore security mechanism for fund, to meet the present and future business center of the system of overall structure, the businessprocess structure and data analysis and policy support, etc can be reached advanced levels. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => [page] => 76 [title_cn] => 地市级住房公积金缴存业务处理系统的设计与实现 [article_dt] => [name_editor] => [reference] => [1]《住房公积金管理条例》,国务院。 [2]《关于调整个人住房公积金存贷款期限和利率等问题的通知》,中国人民银行 [3]《全国住房公积金监督管理信息系统数据接口标准(修订)》 [4]《潍坊市住房公积金政策制度汇编》 [5]何克清《计算机软件工程学》武汉大学出版社,1983 [6]郑人杰《软件工程》(高级) 清华大学出版社,1999 [7][美]Philip Heller 《Java 2 Developer's Handbook》电子工业出版社,2001 [8][美]James Rumbaugh 《UML参考手册》机械工业出版社,2001 [9]蒋晓铭、刘波、张亦华 《JSP程序设计精彩实例》 清华大学出版社,2004 [10]马文刚、谢乐健、管知时《JSP实用编程实例集锦》清华大学出版社,2005 [11]耿祥义、张跃平《JSP实用教程》 清华大学出版社,2002 [12]黄梯云 《管理信息系统》 高等教育出版社,2002 [13]《Introduction to Client/Server systems》 John Wiley&Sons Inc,1997 [14]周亚辉《Java数据库系统项目开发实践》 科学出版社,2005 [15]Dean Leffingwell 《Managing Software requirements》,2004 [16]计磊、李里、周伟《Struts Hibernate Spring整合应用案例》人民邮电出版社,2006 [17]孙卫琴精通Struts:基于MVC的JavaWeb设计与开发人民邮电出版社,2006 [18]余金山《实时UML与Rational Rose Realtime建模案例剖析》电子工业出版社,2007 [19]Ralph R. Young 《Effective requirements practices》科学出版社,2002 [20]Timothy A. Budd《面向对象编程导论》 机械工业出版社,2003 [21]叶达峰《Eclipse编程技术与实例》 人民邮电出版社,2006 [22]柳永坡、刘雪梅、赵长海 《JSP应用开发技术》 人民邮电出版社,2006 [23]David C.Hay《需求分析》清华大学出版社,2003 [24]牛丽平 《UML面向对象设计与分析基础教程》 清华大学出版社,2003 [25]刁成嘉UML系统建模与系统分析机械工业出版社,2007 [26](美)Walker Royce软件项目管理周伯生译机械工业出版社,2002 [27](美)Craig Larman《UML和模式应用面向对象分析与设计导论》机械工业出版社,2002 [28]韩万江姜立新 《软件项目管理案例教材》机械工业出版社,2005 [29]郑人杰,殷人昆,陶永雷 《实用软件工程》(第二版) 清华大学出版社,1997 [30]刘学峰,《河南国税采集评估系统的设计与实现》 山东大学硕士论文,2008 [series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [赵合计] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 赵合计 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 81203 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 51263 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 住房公积金;;管理系统;;J2EE [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 陈光升 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => The Design and Implementation of Housing Provident Fund Deposit Business System [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => TP311.52 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 9 [batch] => 0 [jl_keyword_cn_keyword_en] => j2ee,住房公积金,管理系统 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 4 [id] => i6tq32YBFjIhTVEb64x3 [tags] => 0 ) [9] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 医疗卫生关乎群众生命安全和身体健康,群众对医务工作者这个救死扶伤、生命相托的特殊群体理应有着由衷的崇敬和尊重。但是近年来,看病难看病贵、医患纠纷、食品安全等问题屡见报端,医患关系与医疗卫生行业整体形象不尽人意。形象危机促使政府卫生部门一方面积极推进医改、着力缓解人民群众看病就医的突出问题;另一方面积极探索加强卫生新闻宣传工作,大力宣传医疗卫生行业先进典型,树立医务人员“白衣天使”良好形象,以期构建和谐医患关系,为开展深化医药卫生体制改革工作营造良好的外部环境和舆论氛围,促进医疗卫生事业健康发展。 本文运用传播效果理论,以近年来医疗卫生行业开展的正面典型宣传工作为研究对象,设计实证研究,通过问卷调查了解目前受众对医疗卫生行业典型宣传的接触情况及态度意见,分析传播效果及影响传播效果的因素,并在总结实证研究结果的基础上,为政府传播者进一步加强和改进典型宣传工作提供参考建议。 本文的具体研究内容如下: 第一章,导论。简要概述本文的研究背景、研究目的与意义、研究的思路与内容以及文献综述。 第二章,探究作为“白衣天使”形象塑造的主要手段——典型宣传的有关概念、特点和意义,重点在于厘清“典型”、“宣传”和“典型宣传”的概念,为下文开展实证研究奠定基础。 第三章,我国医疗卫生行业典型宣传效果的实证研究设计。这一章将在回顾传播效果理论的基础上,重点探讨医疗行业典型宣传的实证研究框架(包括实证研究主要内容、研究变量及假设)以及实证研究方法(包括样本量的确定、调查问卷的内容设计、调查方法及数据分析方法设计)。 第四章,实证分析。这一章主要利用图表和SPSS软件对调查得来的样本数据进行统计分析。这些分析包括问卷数据描述性分析、可靠性分析、传播效果与影响因素的相关性分析等。通过对数据的处理,挖掘数据所包含的信息,从中总结宏观结论、找出规律性联系。 第五章,研究结论和政策建议。这一章在分析总结实证研究结果的基础上,针对各因素的影响程度,基于政府传播者的角度提出如何改进医疗卫生典型宣传传播效果的建议措施。 [keyword_plu] => [book_alias] => 1011223664.pdf [controlled_terms] => [complete_time] => 2011-05-10 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-21 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 传播学 [cauthor_ad] => [cscd_No] => [abstract_en] => Medical treatment is especially important for people life safety and health. People are supposed to respect medical personnel who save their lives and alleviate pain. However, in China recent years, the problem of difficult and high cost to access medical service, doctor-patient disputes, food safety problems were reported frequently, thus influencing the relationship between doctor and patient and the images of medical and health industries. To improve the public image, government health ministries prudently carried forward the reform of the pharmaceutical and healthcare systems, and actively carried out propaganda to promote advanced models, establish a "white garment angel" good image and promote the healthy development of the medical and health industry. This article investigates the typical conduct propaganda effects of the medical and health industry by applying the communication effect theory and method of empirical research, analyzes the infective factors of parameters in the model, and at last, makes suggestions about how to improve typical conduct propaganda for the government health ministries. The main contents of the article are as below: Chapter 1. "Introduction". It mainly introduces the background, the purpose, the significance, the basic thoughts and the contents of this article, and the literature review. Chapter 2. "The typical conduct propaganda". It discusses the concept, the characteristic and the significance of typical conduct propaganda, lays a theoretical foundation for the following positive analysis. Chapter 3. "Design the empirical research". It mainly introduces the demonstration designing idea of this study, including the setting of the variable in the questionnaire, the presentation of the research hypothesis, the decision of the research frame, the choosing of the survey sample, the designing of the questionnaire, the choosing of the analyzing methods and so on. Chapter 4. "Empirical analysis". It expatiates the detailed process of the demonstration analyzing, analyzes the data collected from the questionnaire by using the statistical software SPSS. It includes data source, descriptive analysis, reliability analysis and correlation analysis. Chapter 5. "Results and advices of this study". It sums up the results of the demonstration research, provides some suggestions as to how to improve typical conduct propaganda of the medical and health industry. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => [page] => 87 [title_cn] => “白衣天使”的形象建构 [article_dt] => [name_editor] => [reference] => ①董关鹏在“医患和谐关系与战略传播”高级研讨班上的授课内容,2011年3月18日,北京。 ①刘汉俊:《典型宣传的社会价值》,《新闻实践》,2006年第12期,第3页。 ②程曼丽:《政府传播机理初探》。《北京大学学报》,2004年3月,第133页。 ③蒋一峰:《关于典型宣传的若干问题的思考》,《当代传播》,1999年第2期,第47页。 ④徐明明:《媒体议程设置与正面宣传》,《中国广播电视学刊》,2005年6月,第35页。 ①《媒体要重视对几类重要报道领域的改革与创新——主流媒体如何增强舆论引导有效性和影响力之三》,《中国记者》,2004年第1期,第9页。 ②转引自梁建增、孙金岭:《公信力:典型宣传的重中之重》,《采写编》,2005年笫1期,第20页。 ①郭丽华:《试论典型人物报道与受众心理》,广西大学硕士学位论文,2002年5月,中国知网。 ②麦尚文:《中国典型人物报道创新研究》,暨南大学硕士学位论文,2005年5月,中国知网。 ③青岛新闻网:《中国已经没有“白衣天使”了》。http://club.qingdaonews.com/showAnnounce.php?topic id=4115287&board_id=2 ④天涯社区天涯杂谈:《请不要再叫我们“白衣天使”》。http://www.tianya.cn/publicforum/content/free/1/2152809.shtml ⑤2007年4月,卫生部委托中国青年报社社会调查中心联合搜狐网、腾讯网、丁香园网共同进行了中国医患关系大型调查。调查针对公众和医生,设计了两份问卷。截至2007年4月30日,针对公众的调查最终共有23163人参与,其中来自网络的有21642人,报纸问寄问卷1021份,电话调查500人。针对医生的调查最终共有2848人参与。 ①人民网:2011两会调查——你最关心的十大热点问题。http://npc.people.com.cn/GB/28320/213483/ ②新华网:2011年“两会”调查。http://www.news.cn/politics/2011lhdc/ ①医师报:《“假如我足‘两会’代表/委员”调查结果分析》,2011年3月10日 ①朱光潜:《西方美学史》(下卷),人民文学出版社1979年版,第695页。 ②转引自张威:《典型报道:渊源与命运》,《新闻与传播研究》,2002年第2期,第39贝。 ③《现代汉语词典》,商务印书馆2005年版,第304页。 ①韩冰:《典型报道——困顿的现状和未来的革新》,南京师范大学硕士学位论文,2006年5月。 ②苏进跃、戴松:《从一篇奏折看曾国藩推介典型的艺术——兼论当今典型报道的弊端》,《湖南社会科学》,2004年第6期,第192页。 ③丁迈:《典型报道的受众心理实证研究》,中国传媒大学出版社2008年版,第34页。 ④沃纳·J·赛弗林、小詹姆斯·坦卡德:《传播学的起源、研究与应用》,福建人民出版社1985年版,第103页。 ⑤ Garth S.Jowett,Victoria O'Donnell:《宣传与说服》,第25页。 ⑥周鸿铎:《应用传播学史纲》,中国纺织出版社2005年版,第46页。 ①转引自周波:《我国政府传播论》,中央民族大学硕士学位论文,第45页。 ②周立方:《新闻写作研究》,新华出版社1994年版,第2页。 ③郭宇明:《新闻与宣传差异性研究》,河北大学硕士学位论文,第17页。 ④同上。 ⑤王中:《王中文集》,复旦大学出版社2004年版,第242页。 ⑥刘骋:《宣传学视野中的左翼文学》,浙江大学博士学位论文,第3页。 ①东流:《典型宣传的现状及其走势》,《城市党报研究》,2006年第6期,第4页。 ②刘汉俊:《典型宣传的社会价值》,《新闻实践》,2006年第12期,第3页。 ③王凤伟:《典型宣传效应“短期化”现象透视》,《学理论·学术版》2009年第2期,第175页。 ①周鸿铎:《应用传播学史纲》,中国纺织出版社2005年版,第46页。 ①卫生部内部材料,2011年1月。 ①戴元光:《传播学研究理论与方法》,复口.大学出版社2003年版,第27页。 ②戴元光:《传播学研究理论与方法》,复旦大学出版社2003年版,笫28页。 ③周鸿铎:《应用传播学史纲》,中国纺织出版社2005年版,第57页。 ①周鸿铎:《应用传播学引论》,中国纺织出版社2005年版,第312页。 ①卡斯柏·约斯特:《新闻学原理》,第26-27灭。转引自侯晓辉:《中西方社会新闻报道的多维观照》 ①白岩松在“和谐医患与战略传播高级研讨班”上的发言,2011年3月26日。 ②陈小申,《中国健康传播研究:基于政府卫生部门的考察与分析》,中国传媒大学出版社,2009年8月第1版,第24页 ③《中共中国务院关于深化医药卫生体制改革的意见》,2009年3月17日。 ①叶皓,《政府新闻学》,江苏人民出版社,2006年9月第1版,第418页。 ①毛国根、陆春垠:《试论从受众出发增强典型宣传的有效性》,《求实》2005年第2期,第74页。 [1]《中共中央国务院关于深化医药卫生体制改革的意见》(2009年3月17日) [2]《政府信息公开条例》(国务院令第492号) [3]《突发公共卫生事件应急条例》(国务院令第376号) [4]《卫生部关于进一步加强和改进卫生新闻宣传工作的意见》卫办发(2006)63号 [5]《卫生部中宣部关于加强和改进公共医疗卫生领域新闻报道工作的通知》 [6]《卫生部关于进一步加强卫生行业典型宣传工作的意见》 [7]郭庆光:《传播学教程》,中国人民大学出版社,2000版 [8]李良荣:《宣传学导论》,福建人民出版社,1999年版 [9]HaroldD. 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Of all the affective variables, anxiety is considered to be one of the most important factors that pervasively obstruct the efficiency of foreign language learning. As a result, anxiety in English learning has attracted more and more academic concerns in foreign or second language teaching. The study of English learning strategies has long been discussed by educators and linguists. But up to now, few books have specifically dealt with the relationship between English learning strategy use and English learning anxiety. Different from the previous researchers, most of whom mainly paid attention to how to get rid of the negative effects of English learning anxiety on the subjects in universities, the present study, involving two hundred and eighty six subject students from three senior middle schools in Dongying City, explores the correlations between senior middle schools students' English learning anxiety levels and their English learning strategy use and whether a lack of English learning strategies results in their English learning anxiety. The present study aimed to find out answers to the following research questions: (1).What is the present status of English learning anxiety in senior middle schools? (2).What is the present status of English learning strategy use in senior middle schools? (3).What are the correlations between English learning anxiety and English learning strategies? (4).Are English learning strategies useful in English learning? (5).What are the pedagogical implications of the present study? The author first investigated the subjects'English learning status. The majority of the students (about 72 per cent) failed the first English test. Next the author used two questionnaires to investigate the present status of students' English learning anxiety levels and their levels of English learning strategy use.Then the author analyzed the correlations between them. The results of the analysis show that most students are interfered with English learning anxiety in EFL classroom. To be more specific, the senior middle school students at the beginning stage generally have low levels of awareness of English learning strategy use and have high levels of English learning anxiety. There are significant correlations between English learning anxiety and English learning strategies. The students'high levels of English learning anxiety mainly results from a lack of English learning strategy use. A negative correlation exists between them. And there are also some exceptional phenomena in the research. Some students who have high levels of awareness of English learning strategy use have high levels of English learning anxiety. Learning anxiety is very harmful in language learning, and it may finally lead to the students' avoidance of attending English class and classroom participation, concentration failure and a great affective filter. In the following three months, the subjects made use of various strategies in their English learning. Their scores improved in the second English examination. There was a ten per cent drop in the number of the students who failed the examination. So the use of English learning strategies is helpful. Based on the results of the present study, the author puts forward some pedagogical implications. Firstly, the application of English learning strategies in English teaching should be strengthened. Secondly, effective measures should be taken to lower the students'English learning anxiety. The educators should make efforts to make the students "good language learners". [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => [page] => 65 [title_cn] => 高中生英语学习焦虑与学习策略相关性研究 [article_dt] => [name_editor] => [reference] => Aida,Yukie.1994. Examination of Horwitz, Horwitz, and Cope's Construct of Foreign Language Anxiety:The Case of Students of Japanese. The Modern Language Journal, 78, ii.155-167. Allwright, D., and K. M. Bailey (1991) Focus on the Language Classroom:An Introduction to Classroom Research for Language Teachers. Cambridge:Cambridge University Press. Arnold, J.2000. Affect in Language Learning. Beijing:Foreign Language Teaching and Research Press Atkinson,R.C., and Raugh, M.R.1975. An application of the mnemonic keyword method to the acquisition of Russian vocabulary. Journal of Experimental Psychology 104:126-133 Benjamin et al. Two types of test-anxious students:support for an information processing model. Journal of Educational Psychology.1987.79(2),131-136. Bialystok,E.1981. The role of conscious strategies in second language proficiency. Modern Language Journal 65:24-35 Besnier, N.1990. Language and Affect. Annual Review of Anthropology,19,419-511. Brown, A. L., Bransford, J.D., Ferrara, R. A., and Campione, J.C.1983. learning, remembering, and understanding. In J.H. Flavell and M. Markman, Carmichael's manual of child psychology (Vol.3, pp.77-166). New York:Wiley. Brown, G., Anderson, A., Shillcock, R.,& Yule, G. 1984. Teaching talking:Strategies for production and assessment. Cambridge:Cambridge University Press. Chesterfield R. and K Chesterfield.1985. Natural order in children's use of second language learning strategies. Applied Linguistics 6:45-59 Cohen, A. D.2000. Strategies in Learning and Using a Second Language. Beijing:Foreign Language Teaching and Research Press Ellis, R.1994. The Study of Second language Acquisition. Oxford:Oxford University Press Garden, Rand W. Lambert.1972. Attitudes and Motivation in Second Language Learning [M]. Rowley, Mass:Newbury House Horwitz, E. K. Preliminary evidence for the reliability and validity of a foreignanxiety scale. Tesal Quarterly,1986,20(3),559-562. Huang,X. and M. Van Naerssen.1985 Learning strategies for oral communication. Applied Linguistics 6:287-307 Naiman, N. The Good Language Learner. The Ontario Institute for Studies on Education O'Malley, J. M.& Chamot, A. U.1990. Learning Strategies in Second Language Acquisition. New York:Cambridge University Press. Rubin, L.1975. What the "good language learner" can teach us. TESOL Quarterly 9:41-51 Reiss, M.1985 The good language learner:another look Canadian Modern Language Review 41:511-23 Richards, J. C.2002. Longman Dictionary of Language Teaching & Applied Linguics. 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By considering the variation of the Lyapunov functional in every subinterval, the H∞filter design problem is solved. Let the system dynamics be described by the following: where xk E Rn is the state of the system, yk∈Rm is measured output, zk∈Rq is the signal to be estimated,wk∈R9 is the disturbance input that belongs to l2[0,∞). dk is a time-varying delay satisfying 0 [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => [page] => 42 [title_cn] => 离散时变时滞奇异Markov跳跃系统的H_∞滤波时滞分解方法 [article_dt] => [name_editor] => [reference] => [1]C. E. de Souza and M. D. Fragoso, H∞ control for linear systems with Markovian jumping parameters, Control Theory and Advance Technology, 1993,9:457-466. [2]E. K. Boukas and Z. K. Liu, Robust stability and H^ control of discrete-time jump linear systems with time-delays:an LMI approach, Proceedings of the 39th IEEE Conference on Decision and Control,1999:1527-1532. [3]P. Shi,E. K. Boukas and K. Agarwal, Control of Markovian jump discrete-time systems with norm bounded uncertainty and unkown delay, IEEE Transactions on Automatic Control,1999,44:2139-2144. [4]Y. Y. Cao and J. Lams, Stochastic stabilizability and H∞ control for discrete-time jump linear systems with time-delays, J.Franklin,1999, 336:1263-1281. [5]E. K. Boukas and Z. K. Liu, Robust H∞ control of discrete-time Markovian jump linear systems with mode-dependent time-delays, IEEE Transactions on Automatic Control,2001,46:1918-1924. [6]W.H.Chen,Z.H.Guan and P.Yu, Delay-dependent stability and control of uncertain discrete-time Markovian jump systems with modeOdependent time-delays, Systems amd Control Letters,2004,52:361-376. [7]M.Z.Manu and J.Mohammad, Time-Delay systems analysis, Optimization and Applications,1980. [8]秦元勋,刘永清,王联,郑祖麻,带有时滞的动力系统的运动稳定性.北京.科学出版社.1989. [9]X.Li and C.E.de Souza, Criteria for robust stability and stabilization of uncertain linear systems with state-delay, Automatica,1997,33:1657-1662. [10]S.Xu,J.Lam and C.Yang,H∞, and positive real control for linear neutral delay systems, IEEE Trans.Automat.Control,2001,46:1321-1326. [11]Y.S.Moon,P.G.Park,W.H.Kowon and Y.S.Lee, Delay-dependent robust stsbilization of uncertain state-delayed systems, International Journal of Control,2001,74:141-145, [12]E.K.Boukas,Z.K.Liu and G.X.Liu, Delay-dependent robust stability and H∞ control of jump linear systems with time-delay, Internationnal Journal of Control,2001,74:329-340. [13]H.H.Rosenbrock, Structural properties of linear dynamical systems, In-t.J.Control,1974,20(2):191-202. [14]S.L.Campbell, Singular Systems of Differential Equations, Pit-man:London,1994. [15]D.G.Luenberger, Singular dynamic Leontief systems, Econometrics,1977, 45(32):991-995. [16]M.S.Silva and T.P.De Lima, Looking for nonnegative solutions of a Leon-tief dynamic model, Linear Algebra and its Applications,2003,364:281-316. [17]D.J.Hill and Mareels.IMY, Stability theory for differential-algebraic sys-tems with application to power system, IEEE Transactions on Circuits and Systems,1990,37(11):1416-1423. [18]S.S.Sastry and C.A.Desoer, Jump behavior of circuits and systems, IEEE Transactions on Circuits and Systems,1981, CAS-28:1109-1124. [19]L.Hu,P.Shi and Y.Cao, Delay-dependent filtering design for time-delay systems with Markovian jumping parameters, International Journal of Adaptive Control and Signal Processing,2007,21:434-448. [20]E.K.Boukas, Control of Singular Systems with Random Abrupt Changes, Springer;Berlin,2008. [21]S.Xu,J.Lam and X.Mao, Delay-dependent H∞ control and filtering for uncertain Markovian jump systems with time-varying delays, IEEE Trans-actions on Circuits and Systems-I:Regular paper,2007,54:2070-2077. [22]S.Xu and J.Lam, Robust stability and stabilization of discrete singular systems:an equivalent characyerization, IEEE Transactions on Automatic Control,2004,49(4):568-574. [23]S.P.Ma and Z.L.Cheng, An LMI approach to robust stabilization for un-certain discrete-time singular systems, In Proceedings of the 41st IEEE CDC,Las Vegas,Nebada,USA,Dec.2002:1090-1095. [24]E.K.Boukas, Static output feedback control for stochastic hybrid system-s.LMI approach, Automatica,2006,42:183-188. [25]S.P.Ma,X.Z.Liu and C.Zhang, Delay-dependent stability and stabilization of uncertain discrete-time Markovian jump singular systems with time-delay, Anziam Journal,2007,49(1):111-129. [26]E.K.Boukas and Z.K.Liu, Robust H^ Control of Discrete-Time Marko-vian Jump Linear Systems with Mode-Dependent Time-Delays, IEEE tran-s.Automat.Contr.2001,46:1918-1924. [27]E.K.Boukas and Z.K.Liu, Robust H∞ filtering for polytypic uncertain time-delay systems with Markovian jumps, Computers and Electrical En-gineering,2002,28:171-193. [28]J.Wu,T.Chen and S.Xu, Stochastic Stabilization and H∞ Control for Dis-crete Jumping Systems with Time Delays, Asian Journal of Control. Vol.7, 2005,3:223-230. [29]S.Xu and J.Lam, Robust Control and Filtering of Singular Systems, Springer Berlin Heidelberg New York,2006. [series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [马树萍] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 马树萍 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 70105 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 52594 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 奇异马尔可夫跳跃系统;;时变时滞;;H_∞品滤波器;;时滞分解;;线性矩阵不等式(LMI) [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 聂时宁 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => H∞ Filtering for Discrete-time Singular Markov Jump Systems with Time-varying Delay [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => O211.62;O231 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => 奇异马尔可夫跳跃系统,h∞品滤波器,时变时滞,线性矩阵不等式lmi,时滞分解 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 5 [id] => zqtq32YBFjIhTVEbv4Zn [tags] => 0 ) [12] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 研究目的: 本研究旨在观察2型糖尿病患者一级亲属口服糖耐量血清游离脂肪酸、血脂水平变化及其在2型糖尿病发病中的作用,并分析其相关性。探讨游离脂肪酸与IR及胰岛β细胞功能之间的关系,对早期预防糖尿病发生及治疗糖尿病的脂代谢异常均有重要意义。 研究对象及方法: 选自我院老年病房及门诊2型糖尿病家系中一级亲属(均为患者的子女)作为观察对象,进行口服葡萄糖耐量试验(oral glucose tolerance test, OGTT)。按1999年WHO糖尿病诊断标准选取20例正常糖耐量者(NGT)、21例糖耐量减低患者(IGT)和18例糖尿病患者(DM),其中糖耐量减低和糖尿病患者均为首次确诊,且未作任何治疗。 所有实验对象均记录一般临床资料(姓名、性别、年龄、身高、体重、血压、腰围和臀围)并接受口服75克葡萄糖耐量及胰岛素释放试验。测定空腹血浆血糖(fasting plasma glucose, FPG)、甘油三酯(triglyceride, TG)、总胆固醇(total cholesterol, TCH)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol LDL-C)及餐后2小时血糖(postprandial two hour plasma glucose,2hPG)。同时留取血清待统一测定空腹游离脂肪酸(free fatty acids, FFA)、空腹胰岛素(fasting plasma insulin, FINS)及餐后2小时游离脂肪酸(postprandial two hour free fatty acids,2h FFA)、餐后2小时胰岛素(postprandial two hour plasma insulin,2h INS)。并计算体重指数(body mass index,, BMI)、腰臀比(waist to hip ratio, WHR)、稳态模型IR指数(Homeostasis model assessment insulin resistance, HOMA-IR)、稳态模型β细胞功能指数(Homeostasis model assessment-beta-cell function, HOMA-B)、胰岛素敏感指数(insulin sensitivity index, ISI)o 临床及实验数据全部输入计算机,所有数据均采用SPSS10.0统计软件包处理。HOMA-IR、HOMA-B、ISI呈偏态分布,取自然对数转化为符合正态分布后再进行统计分析。计数资料用χ2检验,计量资料用t检验,数值用均数±标准差(x±s)表示。以P<0.05、P<0.01为统计学显著水平。 结果: (1)在糖尿病患者一级亲属中,与NGT组比较,DM组SBP升高(P<0.05);IGT组和DM组DBP升高(P<0.01); IGT组BMI升高(P<0.05),DM组BMI差异升高(P<0.01); IGT组和DM组WHR升高(P<0.01);DM组TC升高(P<0.05);DM组TG升高(P<0.01); IGT组和DM组的LDL-C升高(P<0.01)。 (2)在糖尿病患者一级亲属中,NGT组、IGT组、DM组三组HOMA-IR呈显著升高趋势(P<0.05)。三组HOMA-B呈降低趋势:与NGT组比较,IGT组差异无统计学意义(P>0.05),DM组显著降低(P<0.01);与IGT组比较,DM组差异无统计学意义(P>0.05)。三组ISI呈降低趋势:与NGT组比较,IGT组、DM组ISI差异有统计学意义(P<0.01),与IGT组比较,DM组ISI差异有统计学意义(P<0.05)。 (3)在糖尿病患者一级亲属中,与NGT组比较,IGT、DM组FINS显著升高(P<0.01),与IGT组比较,DM组FINS显著升高(P<0.05);与NGT组比较,IGT、DM组2h INS显著升高(P<0.01)。与NGT组比较,IGT、DM组空腹FFA显著升高(P<0.05)。与NGT组比较,IGT、DM组2h FFA显著升高(P<0.01)。与IGT组比较,DM组2h PG显著升高(P<0.01)。 (4)三组FFA餐后与空腹比较均显著降低(P<0.01)。空腹FFA与其他参数直线相关分析表明,空腹FFA与BMI、WHR、TG、HOMA-IR、FPG呈显著正相关(r分别为0.349、0.305、0.250、0.309、0.201,P<0.05);与HDL-C呈显著负相关(r为-0.27,P<0.01),与HOMA-B、ISI呈负相关(r为-0.114、-0.097,P>0.05)。 (5)餐后2h FFA与其他参数直线相关分析表明,餐后2h FFA与空腹FFA呈显著正相关(r为0.349,P<0.05),与DBP、2h INS、HOMA-IR呈正相关(r分别为0.221、0.325、0.206,P>0.05),与HOMA-B、ISI呈显著负相关(r分别为 -0.129、-0.241,P<0.05)。 结论: (1).2型糖尿病患者空腹血清FFA、TG水平显著升高,存在明显的IR和胰岛β细胞功能缺陷。 (2).T2DM患者一级亲属糖负荷2hFFA与空腹FFA成显著正相关,提示长期FFA的升高加重IR,并损害胰岛β细胞功能。 (3).脂代谢紊乱、IR及β细胞功能缺陷共同参与了有T2DM家族史的高危人群的糖尿病的发生。血清FFA和TG水平的升高是这类人群脂代谢紊乱的主要表现。FFA的升高可能是糖调节异常和脂代谢紊乱共同作用的结果,也可能是导致IR和β细胞功能缺陷的原因。FFA和TG升高可能是这一人群发展为糖尿病的危险因素。 (4).我们应重视T2DM患者一级亲属脂代谢紊乱及IR的早期干预性治疗,监测他们游离脂肪酸的早期改变并采取积极措施,这可能是预防或延缓这类高危人群发生T2DM的重要手段之一。 [keyword_plu] => [book_alias] => 1011228781.pdf [controlled_terms] => [complete_time] => 2011-03-09 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-12 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 内科学 [cauthor_ad] => [cscd_No] => [abstract_en] => Objective: This study aimed to observe the changes of serum free fatty acid, lipid profile in first-degree relatives with different glucose tolerance of type 2 diabetes, and to expore the action of them in the incidence of type 2 diabetes mullitus, and to analyze the correlation. To investigate the relationship between free fatty acid and insulin resistance, beta cell function, and it is very important for the early prevention of diabetes incidence and the treatment for the disorders of lipid metabolism in diabetes are of great significance. Materials and Methods: The first-degree relatives of type 2 diabetes(all for patients children) were selected randomly from courtyard geriatric ward and outpatient service of people's hospital of LinYi as research object, All undertook oral glucose tolerance test,20 cases with normal glucose tolerance impaired glucose tolerance were selected for NGT group, and 21 cases with impaired glucose tolerance were involved in IGT group, and 18 patients with diabetes mellitus were involved in DM group by 1999 WHO diabetes diagnostic criteria, The impaired glucose tolerance and diabetes were first diagnosed, and did not make any treatment. All subjects were recorded general clinical data(including name, sex, age, height, weight, blood pressure, waistline and hip circumference) and receiving oral 75 grams glucose tolerance and insulin release test. Fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and 2h postprandial plasma glucose (2hPG) were observed. At the same time, return serum to uninfied detect fasting serum free fatty acid (FFA), fasting insulin (FINS) and 2h postprandial free fatty acid (2hFFA) and 2h postprandial insulin (2hINS). And calculated body mass index (BMI), waist to hip ratio (WHR), Insulin resistance index (HOMA-IR), beta cell function index (HOMA-B), insulin sensitivity index (ISI) were calculated by homeostasis model assessment. Clinical and experimental data were completely input into computer, all data were aprocessed by SPSS10.0 statistical software. Homa-IR, HOMA-B, ISI showed skewness distribution, taking natural logarithms converted to meet normal distribution, and did statistical analysis. Counting material were tested byχ2 inspection, measuring data were tested by t-test, numerical value were showed by mean±standard deviations (x±s), P< 0.05, P< 0.01 were considered as statistically differences. Results: (1)In the first-degree relatives of type 2 diabetics, compared with NGT group, DBP, WHR, LDL-C were significantly increased in IGT group and DM group (P< 0.01), SBP, TC were increased in DM group (P<0.05). BMI, TG were obviously increased in DM group (P< 0.01), BMI was increased in IGT group (P<0.05). (2)In the first-degree relatives of type 2 diabetics, HOMA-IR rose successively in NGT group, IGT group, DM group three groups (P<0.05), but HOMA-B rend to decrease in the three groups:compared with type NGT group, it had no statistical difference in IGT group (P>0.05), but significantly reduced in DM group (P<0.01); compared with IGT group, it had no statistical difference in DM group (P>0.05). HOMA-B tended to decrease in the three groups:compared with type NGT group, it remarkably reduced in IGT group and DM group (P<0.01), compared with IGT group, it decreased in DM group (P<0.05). (3)In the first-degree relatives of type 2 diabetics, compared with type NGT group, FINS,2h FFA and 2h INS significantly creased in IGT group and DM group (P<0.01), FFA rose in IGT group and DM group (P<0.05). Compared with IGT group, FINS rose in DM group (P<0.05),2hPG significantly creased in DM group (P<0.01). (4)Compared with FFA,2h FFA were significantly lower in the three groups (P<0.01). The linear correlation analysis between FFA and other parameters showed that, FFA positively correlated with BMI, WHR, TG, HOMA-IR and FPG(r were 0.349,0.305,0.250,0.309,0.201, respectively,P<0.05); but significant negatively correlated with HDL-C(r was-0.27, P<0.01), FFA only negatively correlated with HOMA-B, ISI, but had no statistical differences (r were-0.114,-0.097, P>0.05). (5)The linear correlation analysis between 2hFFA and other parameters showed that,2hFFA positively correlated with FFA(r was 0.349, P<0.05); but only positively correlated with DBP,2hINS, HOMA-IR, but had no statistical differences (r were 0.221,0.325,0.206, respectively, P>0.05), significant negatively correlated with HOMA-B, ISI (r were-0.129,-0.241, P<0.05). Conclusions: (1)The fasting serum FFA and TG levels elevated, and there were obvious insulin resistance and beta cell function defects In type 2 diabetes with family history of type 2 diabetes. (2)FFA (2 hours after sugar load) also rose in first-degree relatives with type 2 diabetes, it was suggested that long-term rise of FFA was worsen insulin resistance and injured the function of beta cell. (3)It existed lipid metabolism disorders, and had insulin resistance and impaired beta cell function in the first-degree relatives with abnormal glucose tolerance of type 2 diabetes patients. It is proved that high-risk groups with family history of type 2 diabetes mellitus had the basic of the development of type 2 diabetes mellitus, and also showed that insulin resistance. Beta-cell function defects and lipid metabolism disorders all participated in the development of type 2 diabetes high-risk groups with family history of type 2 diabetes. And the rise of serum FFA and TG levels was the main performance of this kind of crowd of the lipid metabolism disorders. FFA increasing may be the result of abnormal adjustment of sugar and lipid metabolism disorders working together, also may be the results of insulin resistance and beta-cell function defects. The hypertension of FFA and TG may be risk factors of this population to develope type 2 diabetes mellitus. (4) We should pay attention to early interventional treatment on lipid metabolism disorders and insulin resistance in first-degree relatives with type 2 diabetes patients, and detected the early changes of free fatty acid and take active measures, this may be one of important means to prevent or delay the development of type 2 diabetes in the high-risk groups of this kind. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => L0760038 [page] => 47 [title_cn] => 2型糖尿病患者不同糖耐量一级亲属游离脂肪酸水平变化及相关性分析 [article_dt] => [name_editor] => [reference] => [1]童南伟.糖尿病的流行病学.见:刘新民,等主编.实用内分泌学[M].北京人民军医出版社,2004,1176-1179. [2]McGary J D. 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[series] => [fund_type] => [create_time] => [research_area] => 糖脂代谢紊乱 [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [任建民]山东大学齐鲁医院内分泌科 [issue] => [email] => guomiaoly@163.com [datebase] => [degree] => 硕士 [name_tutor1] => 任建民 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 100201 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => ren jian min [scopus_No] => [bulletin_date] => [author_en] => guo miao [job_no] => [volume_label] => 52875 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 2型糖尿病;;一级亲属;;游离脂肪酸;;口服葡萄糖耐量试验 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => 15953902017 [publisher_ad] => [check_180] => [end_page] => [author_cn] => 郭淼 [researcherID] => [fund_ab] => [department_tutor1] => 山东大学齐鲁医院内分泌科 [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => 硕士 [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => 医学院 [title_en] => The Changes of Free Fatty Acid Level and the Correlation Analysis in First-degree Relatives with Different Glucose Tolerance of Type 2 Diabetes [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => Type 2 diabetes mellitus; First-degree relatives; Free fatty acids; Oral glucose tolerance test [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => R587.1 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [jl_keyword_en] => type2diabetesmellitus,freefattyacids,oralglucosetolerancetest,firstdegreerelatives [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [format_student_No_degree_title_cn] => 788695a355b0a33c47a562bd5bf6d589929626174 [hints] => 3 [id] => V6tq32YBFjIhTVEbv4Zn [tags] => 0 ) [13] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 研究背景 脓毒症(sepsis)是由感染引发的全身炎症反应综合症(SIRS).糖皮质激素(GC)用于脓毒症治疗已有50余年历史,临床研究证实大剂量GC无效,而低剂量、长疗程GC能改善脓毒症并发急性呼吸窘迫综合征(ARDS)的患者的预后。脓毒症动物实验发现,不同剂量的GC对肺脏组织糖皮质激素受体(GR)的表达影响不同,但目前缺乏GC对肾脏组织GR表达影响的实验研究 研究目的 观察小剂量氢化可的松(HC)对脓毒症大鼠肾脏病理学变化、糖皮质激素受体-α(GR-α)和核转录因子κB (NF-κB)表达,以及对血浆TNF-α、IL-6、IL-1β、IL-10水平的影响,探讨小剂量糖皮质激素(GC)对脓毒症导致的急性肾损伤(AKI)的保护作用及其机制。 研究方法 健康Wistar大鼠80只,雄性。随机分为假手术组(n=10)、肾损伤组(n=35)和氢考组(HC)(n=35).盲肠结扎穿刺术(CLP)复制脓毒症急性肾损伤模型。术后观察大鼠一般状况及24小时存活率。术后24小时,在存活的肾损伤组和HC组大鼠中各随机选取15只,麻醉,取下腔静脉血和双侧肾脏。HE染色观察肾脏组织病理改变;免疫组织化学法检测肾组织GR-α、NF-κB表达;酶联免疫吸附法(ELISA)测定血浆IL-1β、IL-6、TNF-α、IL-10的水平。 研究结果 1.各组大鼠存活率:术后24小时,假手术组10大鼠术后全部存活,肾损伤组存活15只,存活率43%,HC组存活17只,存活率49%,两组存活率差异无统计学意义(P>0.05) 2.HE染色后光学显微镜观察肾组织结构:假手术组基本正常;肾损伤组肾小管上皮细胞肿胀、脱落,肾小管刷状缘损失,空泡变性;HC组肾小管轻度扩张,肾小管上皮细胞轻度肿胀。 3.免疫组化结果:与假手术组相比,HC组肾脏GR-a表达减少(P<0.05),肾脏NF-κB的表达增多(P<0.01);与肾损伤组相比,HC组肾脏GR-a表达增多(P<0.01),肾脏NF-κB表达减少(P<0.01);与假手术组相比,肾损伤组肾脏GR-a表达降低(P<0.01),肾脏NF-κB表达增多(P<0.01)。 4.ELISA结果:与假手术组相比,HC组血浆L-1β、IL-6、TNF-α、IL-10表达均增加(P<0.01);与肾损伤组相比,HC组血浆IL-1p、IL-6、TNF-α表达显著减少(P<0.01),IL-10表达增多(P<0.01);与假手术组相比,肾损伤组血浆IL-1p、IL-6、TNF-α、IL-10表达均增加(P<0.01)。 结论 小剂量氢化可的松可能通过上调脓毒症大鼠肾脏GR-a的表达,抑制炎症转录因子NF-kB的活性表达,从而降低参与脓毒血症的炎症因子的产生,有效的抑制了脓毒血症的炎症反应,对脓毒血症大鼠肾损伤产生保护作用。 [keyword_plu] => [book_alias] => 1011223570.pdf [controlled_terms] => [complete_time] => 2011-05-04 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-18 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 呼吸内科 [cauthor_ad] => [cscd_No] => [abstract_en] => Background Sepsis is defined as infection plus systemic manifestations of infection. Glucocorticoid (GC) has been used for treatment of sepsis for about fifty years. Clinical studies have proved that high-dose GC has no good in the treatment of sepsis and ARDS,but low dose,long course GC may improve the prognosis of ARDS patients.It has been found in septic anmial experiments that different doses GC have different effects on the expression of GR-a in the lung.But at present there is lack oftrials of impact of GC on GR in the kidney. Objective Observing the impact of low dose hydrocortison on the pathalogical changes of kidey in septic rats, the expressions of Glucocorticoid receptor alpha(GR-a)and nuclear transcription factorκB(NF-κB) in the kidney and the evels of plasma TNF-a,IL-6,IL-1β,IL-10 to investigate the protective effect and mechanism of low dose Glucocorticoid(GC) on sepsis induced acute kidney injury(AKI). Methods Eighty healthy Wistar male rats were randomly divided into sham group(n=10),kidney injury group(n=35) and HC group(n=35).Septic acute kidney injury model was reproduced using cecum ligation and puncture(CLP) method. After the operation,observed the general conditions of rats and survival rate at 24th hour.15 survival rats were randomly choosen from AKI group and HC group.These rats were anesthetized to take IVC blood and both kidneys. Pathological changes of the kidney were detected by HE staining. The expressions of GR-a and NF-KB in the kidney were detected by immunohistochemistry.The expressions of IL-1β,IL-6,TNF-αand IL-10 in the plasma were detected by ELISA. Results 1. The survival rates of each group 24 hours after operation, all the rats in the sham group survived.15 rats survived in AKI group and 17 rats survived in HC group. The survival rates were 43%,49% respectively in AKI group and HC group.The survival rates showed no statistically significant (P>0.05) 2. HE staining of renal structure observed under light microscope The renal structure in the sham group was near normal. Renal tubular epithelial cells swelling and loss,tubular brush border disappeared, tubular vacuolated in AKI group. Renal tubular epithelial cells slightly swelling, tubular slightly expanded in HC group. 3.The results of immunohistochemistry Compared with the sham operation group,the expression of GR-a was decreased(P<0.05) and the expression of NF-κB was increased in HC group(P<0.01). Compared with AKI group,the expression of GR-a was increased and the expression of NF-κB was decreased in HC group(P<0.01);Compared with the sham operation group, the expression of GR-a was decreased and the expression of NF-κB was increased in AKI group(P<0.01). 4. The results of ELISA Compared with the sham operation group,the levels of plasma TNF-a,IL-6,IL-1β,IL-10 were increased in HC group (p<0.01). Compared with AKI group,the levels of TNF-a,IL-6,IL-1βwere reduced and the level of IL-10 was increased in HC group (p<0.01). Compared with the sham operation group, the levels of plasma TNF-a,IL-6,IL-1βwere increased (p<0.01) and the level of IL-10 was increased in AKI group (p<0.01) Conclusions The low dose hydrocortisone can inhibit the activity of NF-kB possibly by means of increasing the experssion of renal GR-a in septic rats. Accordingly reduce the production of inflammatory factors which participate in sepsis. So effectively inhibit the inflammation which happened in the sepsis and protect the renal injury in septic rats.. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => 200812821 [page] => 52 [title_cn] => 小剂量氢化可的松对脓毒症大鼠肾脏糖皮质激素受体-α表达的影响及其对肾损伤的保护作用 [article_dt] => [name_editor] => [reference] => [1]Balk RA, Bone RC.The septic syndrome:definition and clinical implications. Crit Care Clin 1989;5:1-8. 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J Neurosci 1998,18:7462-7473. [49]Burnstein KL, Bellingham DL, Jewell CM, Powell-Oliver FE, Cidlowski JA. Autoregulation of glucocorticoid receptor gene expression. Steroids 56:52-58, 1991. [50]Cidlowski JA, Cidlowski NB. Regulation of glucocorticoid receptors by glucocorticoids in cultured HeLa S3 cells. Endocrinology 109:1975-1982,1981. [51]Mercurio F,Manning AM.Multiple signals converging on NF-κB.Curr Opin Cell Biol 1999; 11:226-232. [52]Heike Bantel, M.Lienhard Schmitz,Armin Raible,et al. Critical role of nuclear factor-KB and stress-activated protein kinases in steriod unresponsiveness.The FASEB Journal 2002; 10:1096. [53]Vottero A,ChrousosGP. Glucocorticoid Receptor P:View I.Trends Endocrinol Metab 1999;10:333-338. [54]Pujols L,Mullol J,Perez M, et al. Expression of the human glucocorticoid receptor alpha and beta isoforms in human respiratory epithelial cells and their regulation by dexamethasone. Am J Respir Cell Mol Biol,2001,24:49-57. [55]Ray A,Prefontaine K.Physical association and functional antagonism between the P65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc.Natl.Acad.SCI.USA 1994;91:752-756. [56]AuphanN,DidonatoJ,Rosette C,et al. Molecular basis for immunosuppression by glucocorticoids:inhibition of NF-κB activity through induction of IKB synthesis. Science 1995;270:286-290. [57]WISSINK, S. et al.1998. A dual mechanism mediates repression of NF-kappa B activity by glucocorticoids. Mol. Endocrinol.12:355-363. [58]SHAMES, B.D. et al.1998. Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes. Shock 10:389-394. [59]POPPERS,D.M.,P.SCHWENGER & J. VILCEK.2000. Persistent tumor necrosis factor signaling in normal human fibroblasts prevents the complete resynthesis of I kappa B-alpha. J. Biol. Chem.275:29587-29593. [60]HeckS,Bender K,Kullmann M,et al..Independent downregulation of NF-κB activity by glucocorticoid receptor.EMBO J 1997; 16:4698-4707. [61]DeBosscher K,Schmitz ML,Vanden Berghe W,et al.Glucocorticoid-mediated repression involves direct interference with transactivation. Proc.Natl.Acad. SCI.USA 1997;94:13504-13509. [62]SharsharT,Gray F,Lorin de la,et,al.Apoptosis of neurons in cardivascular autonomic centres triggered by inducibe nitric oxide synthase after death from septic shock.Lancet 2003,362:1799-1805. [63]Gaillard RC,Turnill D,Sappino P,et al.Tumor necrosis factor alpha inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors.Endocrinology 1990,127:101-106. [64]Martin,H,B.Olander and M.Norman.2001.Reactive hyperemia and IL-6,IL-8,and tumor necrosis factor-alpha in the diagnosis of early onset neonatal sepsis.Pediatrics 108:E61. [65]Reinhart, K.,T. Menges, B. Gardlund, et al.2001. Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis:the RAMSES study. Crit. Care Med.29:765-769. [66]Riedemann, N. C, T. A. Neff, R. F. Guo, K. D. Bernacki, I. J. Laudes, J. V.Sarma, J. D. Lambris, and P. A. Ward.2003. Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J. Immunol.170:503-507. [67]Wang P.,Wu P.,Anthes J. C.,Siegel M. I., Egan R. W., Billah M. M.Interleukin-10 inhibits interleukin-8 production in human neutrophils,(1994) Blood 83, 2678-2683. [1]urney TH, Cockrell JL Jr, Lindberg JS, et al. Spectrum of serum cortisol response to ACTH in ICU patients:correlation with degree of illness and mortality. Chest 1987;92:292-295. [2]Reincke M, Allolio B, Wurth G, et al. The hypothalamic-pituitary-adrenal axis in critical illness:response to dexamethasone and corticotropin-releasing hormone. J Clin Endocrinol Metab 1993; 77:151-156. [3]Paul E,Marik.Critical Illness-Related Corticosteroid Insufficiency. Chhest, 2009,135:181. 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The rapid low-dose (1 microgram) cosyntropin test in the immediate postoperative period:results in elderly subjects after major abdominal surgery. Surgery 1999; 125:431-440 [27]Soni A, Pepper GM, Wyrwinski PM, et al. Adrenal insufficiency occurring during septic shock:incidence, outcome,and relationship to peripheral cytokine levels. Am J Med 1995; 98:266-271. [28]Catalano RD,ParameswaranV,RamachandranJ,et al.Mechanisms of adrenocortical depression during Escherichia coli shock. Arch Surg 1984; 119:145-150. [29]Keri G, Parameswaran V, Trunkey DD, et al. Effects of septic shock plasma on adrenocortical cell function. Life Sci 1981; 28:1917-1923. [30]Jaattela M, Ilvesmaki V, Voutilainen R, et al. Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells. Endocrinology 1991; 128:623-629. [31]Zhu Q,Solomon S..Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides. Endocrinology 1992; 130:1413-1423. [32]Natarajan R, Ploszay S, Horton R, et al. Tumor necrosis factor and interleukin-1 are potent inhibitors of angiotensinⅡ induced aldosterone synthesis. Endocrinology 1989; 125:3084-3089. [33]Jaattela M, Carpen O, Stenman UH, et al. Regulation of ACTH-induced steroidogenesis in human fetal adrenals by TNF--α. Mol Cell Endocrinol 1990; 68:R31-R36. [34]Pariante CM,Pearce BD, Pisell TL,et al.The proinflammatory cytokine, interleukin-1 a,reduces glucocorticoid receptor translocation and function. Endocrinology 1999; 140:4359-4366. [35]Melby JC,Spink WW. Comparative studies of adrenal cortisol function and cortisol metabolism in healthy adults and in patients with septic shock due to infection. J Clin Invest 1958; 37:1791-1798. [36]McCallum RE, Stith RD. Endotoxin-induced inhibition of steroid binding by mouse liver cytosol. Circ Shock 1982;9:357-367. [37]Schlaghecke R,Kornely E,Santen RT, et al. The effect of long-term glucocorticoid therapy on pituitary-adrenal responses to exogenous corticotropin-releasing hormone. N Engl J Med 1992; 326:226-230. [38]Kannisto S, Korpi M, Remes K, et al. Adrenal suppression,evaluated by a low dose adrenocorticotropin test,and growth in asthmatic children treated with inhaled steroids. J Clin Endocrinol Metab 2000; 85:652-657. [39]Zaloga GP.Sepsis-induced adrenal deficiency syndrome. Crit Care Med 2001; 29:688-690. [40]Koo DJ, Jackman D, Chaundry IH, et al. Adrenal insufficiency during the late stage of polymicrobial sepsis. Crit Care Med 2001; 29:618-622. [41]Schroeder S, Wichers M, Klingmuller D, et al. The hypothalamic-pituitary-adrenal axis of patients with severe sepsis::altered response to corticotropin-releasing hormone. Crit Care Med 2001; 29:310-316. [42]Briegel J,Scheelling G, Haller M, et al. A comparison of the adrenocortical response during septic shock and after complete recovery. Intensive Care Med 1996; 22:894-899. [43]Marik PE, Kiminyo K, Zaloga GP. Adrenal insufficiency in critically ill HIV infected patients. Crit Care Med 2002; 30:1267-1273. [44]Ali M, Allen HR, Vedeckis WV, et al. Depletion of rat liver glucocorticoid receptor hormone-binding and its mRNA in sepsis. Life Sci 1991; 48:603-611. [45]Molijn GJ, Koper JW, van Uffelen CJ, et al. Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leukocytes in patients with sepsis and septic shock. Clin Endocrinol 1995; 43:197-203. [46]Melby JC, Egdahl RH, Spink WW. Secretion and metabolism of cortisol after injection of endotoxin. J Lab Clin Med 1960; 56:50-62. [47]Annane D, Sebille V, Troche G, et al. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000; 283:1038-1045. [series] => [fund_type] => [create_time] => [research_area] => 重症医学 [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [吴大玮]山东大学齐鲁医院重症医学科 [issue] => [email] => wyx910@126.com [datebase] => [degree] => 硕士 [name_tutor1] => 吴大玮 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 100201 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => wu da wei [scopus_No] => [bulletin_date] => [author_en] => wu yu xia [job_no] => [volume_label] => 49549 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 脓毒症;;急性肾损伤;;动物实验;;氢化可的松;;糖皮质激素受体-α [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => 13884998375 [publisher_ad] => [check_180] => [end_page] => [author_cn] => 吴玉霞 [researcherID] => [fund_ab] => [department_tutor1] => 山东大学齐鲁医院重症医学科 [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => 硕士 [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => 医学院 [title_en] => The Effect of Low-dose Hydrocortison on the Expression of Glucocorticoid Receptor Alpha of Septic Kidney in Rats and Its Protective Effect on Kidney Injury [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => Sepsis;Acute rena linjury;Animal experiment; Hydrocortison; Glucocorticoid receptor-α [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => R459.7 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [jl_keyword_en] => sepsis,animalexperiment,hydrocortison,glucocorticoidreceptorα,acuterenalinjury [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => acuterenalinjury,hydrocortison,脓毒症,急性肾损伤,糖皮质激素受体α,sepsis,glucocorticoidreceptorα,动物实验,氢化可的松,animalexperiment [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [format_student_No_degree_title_cn] => 3f63bdaad0522abc885fc0406efb3b02-636898320 [hints] => 3 [id] => Iatr32YBFjIhTVEbKpME [tags] => 0 ) [14] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 随着工业文明的发展和人类社会的进步,现代人在享受富足的物质生活与便捷的生活方式的同时,也遭受着由此引发的诸多问题。人与自然生态的矛盾日益突出,人们的精神生态严重失衡,整个西方社会被孤独、隔膜所笼罩。弗吉尼亚·伍尔夫,英国最著名的现代主义作家之一,敏锐地意识到了这些问题,并将自己对生态的认识通过作品表述出来。在作品中,伍尔夫表现出中庸、平衡的生态思想,提倡建立和谐的生态关系。论文以其著名现代主义作品《达洛卫夫人》为例,从自然观、宇宙观、文明观、生死观四个方面系统分析伍尔夫的生态意识。 第一章探讨伍尔夫的自然观。在《达洛卫夫人》一书中,伍尔夫对自然表现出了极大的关注,并将她对自然的看法寓于其中。在她看来,自然具有伟大可亲的一面,但同样也有凶狠可怖的一面。伍尔夫认为人应当对自然怀有感激和敬畏之情。人类不过是自然的一部分,大自然从不以人的意志为转移。然而,现代社会人对生态环境的破坏不断加剧,进而造成了人与自然关系的紧张。针对这种情况,伍尔夫在作品中提出了“天人合一”的理想状态,号召人们顺应自然规律,与自然和平共处。 第二章关注伍尔夫的宇宙观。空间和时间是《达洛卫夫人》中的重要主题。对于宇宙的无限与永恒,伍尔夫有着清醒的认识;同时她也意识到了人类的有限与短暂。二者之间形成了鲜明的对比。小至人类个体大到人类历史,相较于宇宙而言都显得微不足道。伍尔夫致力于探寻人与宇宙的关系,彰显人之于宇宙的意义。在她看来,爱与博爱是人类在宇宙中留下的光辉印迹。伍尔夫在《达洛卫夫人》中传达出的宇宙观是其生态意识的重要组成部分。 第三章谈论伍尔夫的文明观。工业革命以来,英国社会经历了经济高速发展的时期。然而,现代文明在给生态环境与人类生活带来福祉的同时,也对自然及人们的精神生态造成了一定的破坏。特别是一战以后,西方社会充斥着疏离感和虚无感,人们遭遇严重的精神生态危机。伍尔夫目睹了文明带来的福祉与破坏,认为在文明化进程中人们应对生态予以重视。在《达洛卫夫人》中,伍尔夫提出了上述问题的解决办法。她提倡在保护自然环境及关注精神生态的前提下发展现代文明,建立生态与文明的和谐关系。 第四章分析伍尔夫的生死观。伍尔夫对有关生死的问题有着深刻的研究。伍尔夫本人及《达洛卫夫人》中的人物都真切感受到了生的美好与困顿。人们被各自的生存困境所折磨,犹如困兽。伍尔夫并不简单地将死亡视作生命的结束,而是赋予它不可替代的意义。她相信死亡是一种抗争与回归。伍尔夫认为生与死都是生态循环中的一环。通过死亡,人类再次与自然及万物融为一体。除此之外,死亡还能给生者以感悟及前行的动力。 这篇论文在前人研究的基础上,分析了伍尔夫在《达洛卫夫人》中的生态意识。伍尔夫不断强调平衡的重要性,呼吁建立事物之间和谐的生态关系。和谐的精神贯穿于其生态思想的始终。这对于解决现代社会人们所面对的生态问题具有重要的启发意义。 [keyword_plu] => [book_alias] => 1011222954.pdf [controlled_terms] => [complete_time] => 2011-04-11 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-28 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 英语语言文学 [cauthor_ad] => [cscd_No] => [abstract_en] => With the development of industrial civilization and human society, modern people have enjoyed the affluent material life and the convenient lifestyle, but also have suffered from a series of problems. The conflicts between man and the natural ecology become increasingly conspicuous, and people's spiritual ecology is seriously unbalanced. Moreover, the whole western society is shrouded by loneliness and isolation. Virginia Woolf, one of the most famous British modernist writers, sensitively realizes these problems, and conveys her understanding of ecology through her works. Woolf shows her moderate and balanced ecological thoughts in her works and advocates establishing a harmonious ecological relationship. Taking her famous modernist novel Mrs. Dalloway as an example, this thesis analyzes Woolf's ecological awareness systematically from the perspectives of her thoughts about nature, idea of the universe, outlook on civilization and view of life and death. The first chapter talks about Woolf's thoughts about nature. In Mrs. Dalloway, Woolf shows great concern about nature, and conveys her thoughts about nature in it. In her opinion, nature has the great and amiable side, but also has the cruel and horrible face. Woolf thinks that man should have the feeling of gratitude and awe to nature. Humans exist as part of nature in the world, and nature is independent of man's will. However, modern people cause severe damage to nature, which destroys the harmonious relationship between man and nature. Therefore, in the work Woolf proposes the ideal condition of the unity of nature and man. She calls on people to conform to the law of nature, and coexist with nature peacefully. The second chapter focuses on Woolf's idea of the universe. Space and time are important themes in Mrs. Dalloway. Woolf has a clear understanding of the infinity and eternity of the universe, and she also realizes the finity and transience of man. These two form a sharp contrast. Compared with the universe, even the whole human history seems to be meaningless, let alone an individual man. Woolf devotes herself to exploring the relationship between man and the universe, and revealing the meaning of man to the universe. As far as she is concerned, universal love is a glorious imprint that humans leave in the universe. Woolf's idea of the universe shown in Mrs. Dalloway is an important part of her ecological awareness. The third chapter discusses Woolf's outlook on civilization. Since the industrial revolution, the English society has experienced a period of economic booming. However, modern civilization not only brings benefit to ecological environment and people's lives, but also causes damage to nature and people's spiritual ecology. Especially after the War, the western society is flooded with the feeling of alienation and nothingness, and people suffer from a serious spiritual ecological crisis. Woolf witnesses the benefit and damage brought by civilization, and she believes people should pay attention to ecology in the process of civilization. In Mrs. Dalloway, Woolf provides solutions to problems above. She advocates that the development of modern civilization should be on the premise of protecting natural environment and caring about spiritual ecology, so as to establish the harmonious relationship of ecology and civilization. The last chapter analyzes Woolf's view of life and death. Woolf has a profound study on problems involving life and death. Both Woolf herself and the characters in Mrs. Dalloway deeply feel the beauty and hardships of life. People are tortured by different dilemmas, fighting like trapped beasts. Instead of simply treating death as the end of life, Woolf endows death with irreplaceable significance. She believes that death is a kind of revolt and return. Woolf thinks both life and death are links in the ecocycle. Through death, humans become a whole with nature and all living things again. Apart from this, death also gives inspiration and encouragement to others. Based on the studies of predecessors, this thesis explores Woolf's ecological awareness in Mrs. Dalloway. Woolf puts great emphasis on the importance of balance, and appeals to the public to establish a harmonious ecological relationship among things. The harmonious spirit runs through her ecological awareness, which is a great enlightenment for modern people to solve the ecological problems. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => 200810837 [page] => 73 [title_cn] => 论伍尔夫在《达洛卫夫人》中的生态意识 [article_dt] => [name_editor] => [reference] => Alt, Christina. Virginia Woolf and the Study of Nature. Cambridge:Cambridge University Press,2010. Baxter, Brian. Ecologism:An Introduction. Edinburgh:Edinburgh University Press, 1999. Bell, Quentin. Virginia Woolf:A Biography. London:The Hogarth Press,1990. Bell, Anne Olivier & Andrew, McNeillie, (ed.). The Diary of Virginia Woolf. London: Hogarth,1977. Berman, Jessica. 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nature; universe; civilization; life and death [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => I561 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 英文 [jl_keyword_en] => universe,civilization,ecologicalawareness,lifeanddeath,nature [author_test] => Array ( [0] => Array ( [sure] => 1 [irInspect_tag] => [irAuthorType] => [name] => 申富英 [u_index] => 1 [irtag] => 2 [t_index] => 0 [irTsTag] => [irTypical] => [person_id] => 23231 ) ) [sys_author_id_arr] => 23231申富英 [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => 生死,nature,universe,自然,宇宙,lifeanddeath,生态意识,civilization,文明,ecologicalawareness [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => 23231 [sys_author_id] => 23231 [format_student_No_degree_title_cn] => 7981095d8731ef024c74a4360f0deacb [jl_pub_year] => 2011 [jl_author_test] => usureu1,uirtagu2,uirtypicalu,uirtstagu,upersonidu23231,uuindexu1,uirauthortypeu,unameuu7533u5bccu82f1,uirinspecttagu,utindexu0 [sys_author_jg_last_arr] => 山东大学外国语学院英语系 [jl_keyword_cn] => 文明,自然,生态意识,生死,宇宙 [hints] => 4 [id] => cqtr32YBFjIhTVEbGJFJ [tags] => 0 ) [15] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 研究背景:糖尿病是严重危害人类健康的疾病,其患病率不断上升。目前尚缺乏有效根治的方法。不论是1型糖尿病还是2型糖尿病,胰岛β细胞相对或绝对不足是其发生的共同病理生理学基础。近年来,以胰腺移植,胰岛细胞移植和干细胞移植为主的再生治疗为糖尿病根治带来了希望。但供体缺乏及免疫排斥反应限制了胰腺移植及胰岛移植的推广应用。骨髓来源干细胞具有多向分化能力。近来研究显示骨髓间充质干细胞(bone marrow mesenchymal stem cells, MSCs)移植可以改善糖尿病动物模型的病情,为治疗糖尿病治疗开辟了新的思路。有研究认为,糖尿病动物症状的改善可能是MSCs在某些因子或激素刺激下诱导分化为胰岛素分泌细胞所致,即转分化(trans-differentiation).然而,还有一些研究表明,找不到足够的证据认为移植后的胰岛素分泌细胞来源于移植的骨髓干细胞。近期研究表明[9-10]MSCs可通过旁分泌机制(paracrine mechanisms)对胰岛细胞起保护作用,但MSCs能否通过抑制胰岛β细胞凋亡发挥保护作用尚不清楚,其中的分子机制有待于进一步研究。 研究目的:通过构建胰岛细胞凋亡模型,探讨骨髓间充质干细胞(BMSCs)对过氧化氢(H2O2)诱导胰岛β细胞凋亡的影响及其机制。 研究方法:180~200 g健康雄性SD大鼠,无菌条件下分离并培养大鼠BMSCs,以H2O2作用于大鼠胰岛瘤细胞INS—1细胞构建凋亡模型,通过Transwell装置实现INS—1细胞与BMSCs共培养。实验分为6组:单独INS—1细胞培养组(A组);INS-1 +H2O2处理组(B组);BMSC +INS-1 Transwell共培养组(C组);BMSC +INS-1 +H2O2 Transwell共培养组(D组);INS-1+H2O2+1400W40μmol/L组(E组);INS-1 +H2O2 +1400W 80μmol/L组(F组)。MTT法检测细胞存活率,Annexin V/PI染色流式细胞技术检测细胞凋亡水平,应用Griess反应检测产生的NO生成的相对量。 研究结果:H2O2显著降低INS-1细胞存活率,引起INS—1细胞凋亡,且呈剂量依赖性。通过Transwell与BMSCs共培养后,由H2O2诱导的INS-1凋亡细胞比例下降,与单独H2O2刺激组相比,细胞凋亡率下降了约26.3%,差异有统计学意义(P<0.05)。共培养亦可使细胞NO水平下降19%,与B组差异有统计学意义(P=0.01),作用与iNOS抑制剂1400W相似。 结论:BMSCs通过Transwell共培养显著抑制H2O2诱导的INS—1细胞凋亡,其作用机制可能通过BMSCs旁分泌作用抑制iNOS-NO表达来实现,为进一步利用BMSCs防治糖尿病提供了理论依据。 [keyword_plu] => [book_alias] => 1011223551.pdf [controlled_terms] => [complete_time] => 2011-05-18 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-12 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 内科学 [cauthor_ad] => [cscd_No] => [abstract_en] => Background:Diabetes are one kind of severely impair human health disease, and its prevalence rate rises unceasingly. At present, the insulin substitution treatment was still the main method to treat diabetes. How can permanently cure diabetes becomes one of puzzled questions in endocrine domain. Diabetes mellitus type 1 and 2 (T1DM and T2DM) are complex multifactorial diseases. Loss ofβcell function caused by reduced secretory capacity and enhanced apoptosis is a key event in the pathogenesis of both diabetes types. The transplantiotion of islet cells can treat 1 and 2 diabetes, but the lack of donor and excessiveβcell apoptosis make it hard to be put into use in routine clinical practices. Bone marrow derived cells have the ability of self-renewal and multi-potential of differentiation. In recent years, some researchs demonstrated that the transplantion of bone marrow mesenchymal stem cells (BMSCs) might ameliorate the condition of diabetes animal model, which offered a novel way to cure diabetes. Some researchs have showed that MSCs trans-differentiation into insulin producing cells (IPCs) may partly account for the therapeutic action. However, also some research indicated that little evidence was proved trans-differentiation of bone marrow-derived cells into pancreatic beta cells. Moreover, it cannot explain the disease amelioration after transplantation, regardless in time limit or extent. Some research had confirmed that MSCs may secrete a series of cytokines and the growth factors (GF), these factors play the protective function to periphery cells, which is called paracrine mechanisms. Recent studies have showed that paracrine effects play a significant part in the recreate and and repair of tissues. Therefore, we surmise that paracrine is the mechanism of MSCs'effect to diabetic animals. Objective:To investigate the effect of BMSCs on hydrogen peroxide (H2O2)—induced apoptosis in INS—1 cell by establish aβcell apoptosis model, and the possible mechanism involved. Methods:Isolation and culture BMSCs under sterile conditions from healthy male rats about 180~220 g. INS—1 cells induced by H2O2 to establish theβcell apoptosis model. The apoptotic INS—1 cells were co-cultured with BMSCs. The experiment consisted of 4 groups:Group A: INS—1 cells culture group (Control group); Group B:H2O2 treatment group; Group C:INS—1 cells and BMSCs coculture group; Group D:INS—1 cells and BMSCs coculture with H2O2 treatment group; Group E:iNOS inhibitor 1400W 40μmol/L and H2O2 treatment group; Group F:NOS inhibitor 1400W 80μmol/L and H2O2 treatment group. Cell viability was mesured by MTT. Annexin V—PI doubled staining of flow cytometry was used to quantify apoptosis ratio. NO production was determined by Griess method. Research Results:INS—1 cell viability was reduced by H2O2 in a dose-dependent manner. The cell viability was obviously decreased when the concentration of H2O2 in 40μmol/L or more. With Transwell co-culture, H2O2 induced INS—1 cell apoptosis ratio was significantly lower than in H2O2 group (P<0.05),also the production of NO was decline sharply compared with the group B (P=0.01), which effection was similar with that of 1400W. Conclusion:BMSCs can protect INS—1 cells from apoptosis, induced by H2O2. The mechanism my may be related to the paracrine mechanisms of BMSCs through inhibiting iNOS-NO pathway. The simulation results are valuable theoretical basis for further research on prevention and control diabetes by the utilization of BMSC. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => 200812801 [page] => 58 [title_cn] => 骨髓间充质干细胞通过抑制iNOS-NO途径影响INS-1细胞凋亡的研究 [article_dt] => [name_editor] => [reference] => 1. Gisela D, Peter K D, Martina D. Oxidative stress and beta-cell dysfunction [J]. Pflugers Arch,2010,460(4):703-718 2. Ryan E A, Lakey J R, Paty B W, et al. 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[series] => [fund_type] => [create_time] => [research_area] => 内分泌与代谢病 [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [陈丽]山东大学齐鲁医院内分泌科 [issue] => [email] => rachelshh@163.com [datebase] => [degree] => 硕士 [name_tutor1] => 陈丽 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 100201 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => chen li [scopus_No] => [bulletin_date] => [author_en] => sun hui huan [job_no] => [volume_label] => 48981 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 胰岛β细胞;;凋亡;;iNOS;;骨髓间充质干细胞;;共培养 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => 15165142806 [publisher_ad] => [check_180] => [end_page] => [author_cn] => 孙慧环 [researcherID] => [fund_ab] => [department_tutor1] => 山东大学齐鲁医院内分泌科 [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => 硕士 [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => 医学院 [title_en] => Bone Marrow Mesenchymal Stem Cells Protects INS-1 Cells from Hydrogen Peroxide-Induced Apoptosis [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => INS-1; Apoptosis; iNOS; Bone Marrow Mesenchymal Stem Cells; Co-culture [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => R587.1 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [jl_keyword_en] => ins1,bonemarrowmesenchymalstemcells,inos,coculture,apoptosis [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => coculture,凋亡,骨髓间充质干细胞,共培养,胰岛β细胞,inos,apoptosis,bonemarrowmesenchymalstemcells,ins1 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [format_student_No_degree_title_cn] => fbce5343d2e1625f5e65f131964cefdb-351255858 [hints] => 3 [id] => matr32YBFjIhTVEbO5Uc [tags] => 0 ) [16] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 随着我国经济社会的迅猛发展,水污染日趋加剧,由此造成的水体重金属污染问题也日益严重。目前针对这一问题,越来越多的学者采用生物质吸附剂进行治理;生物质吸附剂以其廉价易得、可生物降解等特性,越来越成为水体重金属污染治理的研究热点。本论文在综合国内外大量相关文献的基础上,以我省典型的农业秸秆——麦草秸秆作为原料合成生物质两性螯合吸附剂,并着重探讨改性麦草秸秆两性螯合吸附剂对两种典型重金属离子(Cu(Ⅱ)和Cr(Ⅵ))的吸附特性、吸附容量及吸附机理研究。主要研究内容及结果如下: 本研究以N,N-二甲基甲酰胺为介质,利用麦草秸秆与环氧氯丙烷、乙二胺、三乙胺的胺化反应,制备改性麦草季胺盐阳离子型吸附剂;再以异丙醇为溶剂,一氯乙酸为接枝反应试剂,得到改性麦草两性螯合吸附剂。通过单因素实验和正交实验,以对水溶液中Cu(Ⅱ)和Cr(Ⅵ)的去除率为指标,研究活化剂投加量、反应试剂投加量、反应温度、反应时间等影响因素,确定出最优合成条件,并得到了最佳改性产物。结果表明,最优合成条件为:氢氧化钠投加量、一氯乙酸投加量、温度、时间分别为5 mL、3.402g、60℃、2.5h;其中一氯乙酸投加量是合成反应过程的关键影响因素。通过多种化学方法和现代分析仪器,对改性前后麦草的结构形貌、组成元素和特征化学基团等进行表征,结果表明,在结构形貌方面,改性后麦草表面更加光滑;在元素含量方面,改性后麦草含氮量大大增加;在特征基团方面,改性后麦草明显增加了胺基基团和羧基基团。 通过静态吸附法研究改性麦草秸秆对模拟水中Cu(Ⅱ)和Cr(Ⅵ)的吸附效果并对结果进行分析。与原麦草相比,改性后麦草秸秆对水中Cu(Ⅱ)和Cr(Ⅵ)的吸附量明显增加;去除效果受pH值的影响较大,pH值越高,对水中Cu(Ⅱ)的去除率越高,而Cr(Ⅵ)则恰恰相反。伪二级动力学方程可以较好地描述两种离子在改性麦草秸秆上的吸附过程,吸附过程受颗粒内扩散控制,但并不是唯一的速率控制步骤。吸附过程的焓变均为正值,且小于40 KJ mol-1,表明改性麦草秸秆对两种离子的吸附是一个吸热的物理吸附过程。Cu(Ⅱ)和Cr(Ⅵ)的吸附等温线分别对Langmuir和Freundlich符合的好,说明改性麦草秸秆吸附Cu(Ⅱ)是以单层吸附为主,而对Cr(Ⅵ)存在一定程度的多层吸附。吸附过程的熵变均为正值,表明吸附过程中固液界面反应体系的自由度增加了。 改性麦草秸秆对混合离子的同步吸附性能研究结果表明:Cu(Ⅱ)和Cr(Ⅵ)在两性麦草上存在竞争吸附,且对Cr(Ⅵ)的吸附性能更佳,这一结果与单一体系中Cr(Ⅵ)的最大吸附量远远大于Cu(Ⅱ)的研究结果相一致,说明引入了较多的胺基基团;同时,将由不同的离子化次序向原麦草中引入胺基和羧基基团得到的产品的最大吸附量进行比较,结果表明,后加入的改性基团对一种产品的改性更有优势。综合判断可知,改性麦草秸秆对水中Cu(Ⅱ)和Cr(Ⅵ)的吸附主要为物理吸附过程,对Cr(Ⅵ)的吸附主要靠引入的季胺基团与之发生静电吸附来解释,而对Cu(Ⅱ)的吸附则是由于胺基基团的螯合和羧基的静电吸附同时作用。 [keyword_plu] => [book_alias] => 1011222898.pdf [controlled_terms] => [complete_time] => 2011-05-10 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-22 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 环境工程 [cauthor_ad] => [cscd_No] => [abstract_en] => With the development of economy in our country, water pollution has become a serious environmental problem, particularly heavy metal pollution. At present, biomass adsorbents have been used to solve this problem by more scholars and became the research hotspot due to its properties of cheapness, biodegradability and so on. Therefore, wheat straw was modified to a novel biomass amphoteric chelate adsorbent (WSACA), and the adsorption properties, adsorption capacities and adsorption mechanism research of two typical heavy metal ions (Cu (II) and Cr (VI)) have been discussed. WS were modified by epichlorohydrin, ethylenediamine (EDA) and triethylamine in the presence of N, N-dimethylformamide (DMF) and then reacted with chloroacetic acid, finally WSACA was obtained. A series of WSACA were made under different modification conditions, such as the dosage of reactant, reaction temperature and reaction time. Then a suitable modification process and modified products were determined according to the removal efficiencies of Cu (II) and Cr (VI) from aqueous solution onto WSACA in single factor experiments and orthogonal experiments. The optimal conditions used in the preparation of WSACA could be concluded as:VNaoH(40wt%)、Mchloroacetic acid、Temperature and Time are:5 mL、3.402g、60℃,2.5h, respectively. The dosage of chloroacetic acid was considered as the key influential factor in the preparation of WSACA. The physical and chemical characteristics of WSACA were investigated by varies physical chemistry methods and modern instruments analysis. The results demonstrated that the physical and chemical characteristics of WSACA had significant difference with those of WS. The surface of WSACA was clearer and smoother in comparison with WS. IR spectrums indicated appearance of amino and carboxyl groups in the structure of WSACA and it was validated by the elemental analysis which indicated a significant increase of nitrogen content in WSACA. The adsorption performances of WSACA for Cu (II) and Cr (VI) were tested by batch adsorption experiments, and the dosage of WSACA, pH,time, ionic strength, thermodynamics and the effects of several factors on kinetics were studied in batch experiments. The results showed that WSACA was particularly effective to remove Cu (Ⅱ) and Cr (Ⅵ). Their removal abilities were influenced by initial pH of aqueous solution significantly, and the removal rate for Cu (Ⅱ) increased as pH increased, but Cr (Ⅵ) was just the opposite.The kinetics study indicated that the pseudo-second-order equation was best suitable in describing the process of Cu (Ⅱ) and Cr (Ⅵ) adsorption ontoWSACA. In addition, intraparticle diffussion existed in the adsorption process but was not the only rate-limiting step. The low activation energy of the adsorption suggested a physisorption process for Cu (Ⅱ) and Cr (Ⅵ) adsorption. The equilibrium isotherm showed that the adsorption system for Cu (Ⅱ) was consistent with Langmuir equation and belonged to monolayer adsorption, while the adsorption of Cr (Ⅵ) fitted to Freundlich model well and multilayer adsorption was also existed to a certain extent.The negative values of standard free energy (△G) and positive enthalpy (△H) indicated that the adsorption of Cu (Ⅱ) and Cr (Ⅵ) onto WSACA were a spontaneous and endothermic process. The synchronous adsorption performance of mixed ions onto WSACA was also studied in the binary system, competitive adsorption was exsisted between Cu(Ⅱ) and Cr(Ⅵ) and there was the higher affinity of wheat straw for Cr(Ⅵ),which was consistent with the results in the binary system.The order of by-product modification appears to influence ion binding in most cases, the final modification appeared to favor a product that has strong characteristics of that modification. In a word, there were both physisorption processes for Cu (Ⅱ) and Cr (Ⅵ) onto WSACA, the adsorption mechanism of Cr (Ⅵ) was probably due to the electric attractive of quaternary amino groups and both of chelate of amino groups and static adsorption of carboxyl groups were likely to explain the adsorption of Cu (Ⅱ) onto WSACA. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => [page] => 87 [title_cn] => 麦草两性螯合吸附剂的研制及对Cu(Ⅱ)和Cr(Ⅵ)的吸附性能研究 [article_dt] => [name_editor] => [reference] => [1]杨帆.生物质基阳离子吸附剂的制备及其对染料吸附的研究[D].合肥:中国科学技术大学,2009. [2]中国科学院生命科学与生物技术局.工业生物技术发展报告[M].北京:科学出版社,2007. [3]周领.秸秆类型和土壤性质对CO2C释放速率和土壤pH影响的研究[D].杭州:浙江大学,201 0. [4]陈中玉,张祖立,白小虎.农作物秸秆的综合开发利用[J].农机化研究,2007,5,194-196. [5]韩鲁佳,闫巧娟,刘向阳.中国农业秸秆资源及其利用现状[J].农业工程,2002.5:3-4. [6]陈继富,张超美,刘金香.高蛋白整秸秆氨化饲料研究及其应用前景[J].作物杂志,2005,2:10-12. [7]胡晓霞,李进贤,崔峰等.农作物秸秆青贮对农村卫生影响的调查研究[J].职业与健康,2003,19(5):88-89. [8]许醒.麦草阴离子吸附剂的研制及对磷酸根的吸附性能研究[D].济南:山东大学,2009. 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[series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [岳钦艳] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 岳钦艳 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 83002 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 49471 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 麦草;;两性螯合吸附;;Cu(Ⅱ);;Cr(Ⅵ) [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 钟倩倩 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => Preparation of Wheat Straw Amphoteric Chelate Adsorbent and Study of Its Cu(Ⅱ) and Cr(Ⅵ) Adsorption Properties [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => X52 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 9 [batch] => 0 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 3 [id] => m6tr32YBFjIhTVEbKpMF [tags] => 0 ) [17] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => Peroxynitrite (ONOO-)是一氧化氮和超氧阴离子的反应产物。ONOO-作为强氧化剂,参与体内一系列病理生理过程。在病理条件下,NO过量产生的细胞毒作用主要归咎于ONOO的形成。ONOO-可通过不同的信号途径影响肿瘤的发生发展过程。事实上,ONOO-可以穿透双层磷脂膜,诱导脂质过氧化,干扰线粒体的功能,影响细胞的代谢,进而损伤DNA,引起包括肿瘤细胞在内的各种细胞的坏死和/或凋亡。下咽癌,是头颈部最常见的恶性肿瘤之一,近年来其发生率呈显著上升趋势。尽管治疗手段的进步在一定程度上改善了患者的生命质量,但多年来患者总体生存率未有明显提高。因此,探讨新的肿瘤相关基因,揭示下咽癌发生的分子机制,有助于产生新的有效治疗策略。 PDCD4是近年来备受关注的一种程序性细胞死亡调控基因,也是一种抑癌基因。PDCD4位于染色体10q24上,其表达产物与真核细胞翻译起始因子e IF4A结合,从而抑制核糖体复合物的形成和蛋白质的合成。PDCD4在正常组织中普遍表达,而在恶性肿瘤中表达下调甚至缺失。PDCD4在肿瘤组织中的低表达状态与肿瘤的浸润、转移及预后密切相关。值得关注的是,在一些细胞的凋亡过程中,PDCD4表达增高。迄今为止,ONOO-诱干预条件下,PDCD4在FaDu细胞(下咽癌细胞系)表达状况的研究鲜有报道。 盘状结构域受体(Discoidin Domain receptors, DDRs)是最近发现的一类带有盘状结构域的跨膜受体型酪氨酸激酶,包括DDR1和DDR2两种亚型存在。DDR1主要在一些肿瘤细胞中高表达,而DDR2主要表达于心、骨骼肌、肺、脑和肾的间质细胞。本课题从PDCD4和盘状结构域受体(Discoidin domain receptor,DDRs)的表达为切入点,探讨ONOO对FaDu细胞的作用及机制。 在本实验中,以不同浓度的ONOO-作用于体外培养的FaDu细胞,采用流式细胞仪测定细胞凋亡率,采用噻唑蓝(MTT)比色法测定细胞生存率。以吖啶橙和Ho33342荧光染色观察细胞的形态学改变。采用Western-blot技术检测PDCD4、DDR1、DDR2蛋白的表达。采用RT-PCR技术检测PDCD4、DDR1、DDR2 mRNA的表达。 结果显示: (1) ONOO显著抑制FaDu细胞细胞增殖。 (2) ONOO主要通过诱导细胞凋亡抑制FaDu细胞增殖。 (3) ONOO-作用下,FaDu细胞PDCD4 mRNA及蛋白水平增加显著。 (4) ONOO作用下,FaDu细胞DDR1mRNA及蛋白水平总体上呈现下降趋势。 (5)在ONOO作用下,FaDu细胞中的DDR2 mRNA及蛋白水平总体上呈现下降趋势。 结论: ONOO-主要通过启动凋亡途径有效抑制(?)FaDu细胞增殖。在ONOO-诱导FaDu细胞凋亡的信号转导途径中,PDCD4及DDR1、DDR2基因可能起到关键性作用。本研究从一个侧面,为揭示下咽癌与氧化胁迫的关系提供了实验依据。 [keyword_plu] => [book_alias] => 1011230213.pdf [controlled_terms] => [complete_time] => 2011-05-04 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-19 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 病理学与病理生理学 [cauthor_ad] => [cscd_No] => [abstract_en] => Peroxynitrite (ONOO-), a product of nitric oxide and superoxide anion interaction, is a potent and versatile oxidant implicated in a number of pathophysiological processes. Mounting evidence suggests that toxicity of nitric oxide is mainly attributable to the production of ONOO- rather than itself. In fact, ONOO-can diffuse freely across phospholipid membrane bilayers to affect cell metabolism by inducing lipid peroxidation, interfering with mitochondrial function, damaging DNA, and mediating necrosis and apoptosis in different cell types, including cancer cell. Hypopharyngeal carcinoma, which derives from a subsite of the upper aerodigestive tract, is one of the most common cancers in head and neck. Although numerous treatment approaches have been employed, the long-term survival rates of patients suffering from the disease have been improved only minimally during the past two decades. Therefore, studies of the potential new drug targets of the tumor can not only get insight into the mechanisms underlying the pathogenesis of hypopharyngeal carcinoma, but, in turn, offer effective therapeutics as well. Recently, programmed cell death 4, PDCD4, which is identified as a novel tumor suppressor gene, has generated considerable interest in tumor biology. PDCD4 was originally found as a tumor related gene in humans and mapped to chromosome 10q24. PDCD4 protein is known to bind eukaryotic initiation factor 4A that inhibits translation initiation. PDCD4 is ubiquitously expressed in normal tissues, but, lost or suppressed expression of PDCD4 in several tumors that correlates with tumor progression and poor prognosis. Notably, it has been found that PDCD4 is up-regulated during apoptosis in several cell types. To date, however, the expression of PDCD4 in ONOO- induced apoptosis of the FaDU cells is unknown. Discoidin domain receptors (DDRs), the nonintegrin-type receptors for collagen, consist of two closely related types, i.e., DDR1, which mainly is mainly expressed in tumor cells, and DDR2, which is highly expressed in mesenchymal cells. Therefore, the present study was designed to investigate whether FaDU cells experienced apoptosis following treatment with ONOO-, with special attention given to the induction of PDCD4, DDR1 and DDR2 activities in this process. In vitro cultured FaDu cells were subjected to various concentrations of ONOO-, then, the rate of cell apoptosis was measured by flow cytometry.The cell viability was quantified by MTT assay. The morphological changes were observed by acridine orange cytochemistry staining and Ho33342 and PI double staining to determine whether cell experienced apoptosis under the stress of ONOO-. The protein expressions of PDCD4, DDR1 and DDR2 were examined by western blot in response to ONOO-. The mRNA expressions of PDCD4, DDR1 and DDR2 were analyzed by RT-PCR. We demonstrated that ONOO- decreased the survival rates of FaDu cells in a concentration-dependent manner, implying that ONOO- was able to inhibit the growth of FaDu cells in vitro. Under the stress by ONOO-, the expression of PDCD4 gene was apparently increased at both mRNA and protein levels. The expressions of DDR1 and DDR2 genes were finally decreased at both mRNA and protein levels. In conclusion, these data suggested that ONOO- can effectively suppress proliferation of FaDu cells via the induction of apoptosis. Our findings demonstrate that PDCD4, DDR1 and DDR2 gene may play an important role in ONOO--induced apoptosis in FaDu cells, which may offer a new target for the treatment of hypopharyngeal carcinoma. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => [page] => 55 [title_cn] => Peroxynitrite诱导下咽癌细胞凋亡与PDCD4,DDR1及DDR2基因活性相关性的研究 [article_dt] => [name_editor] => [reference] => 1. Schildknecht S, Ullrich V. Peroxynitrite as regulator of vascular prostanoid synthesis.Arch Biochem Biophys.2009; 484(2):183-9. 2. Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. 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Salgo MG, Squadrito GL, Pryor WA. Peroxynitrite causes apoptosis in rat thymocytes. Biochem Biophys Res Commun 1995; 215:1111-1118. 14.Ahmad R, Rasheed Z, Ahsan H. Biochemical and cellular toxicology of peroxynitrite:implications in cell death and autoimmune phenomenon. Immunopharmacol Immunotoxicol.2009;31(3):388-96. 15. Li J, Su J, Li W, Liu W, Altura BT, Altura BM. Peroxynitrite induces apoptosis in canine cerebral vascular muscle cells:possible relation to neurodegenerative diseases and strokes. Neurosci Lett.2003; 350(3):173-7. 16. Li J, Li W, Su J, Liu W, Altura BT, Altura BM. Peroxynitrite induces apoptosis in rat aortic smooth muscle cells:possible relation to vascular diseases. Exp Biol Med (Maywood).2004; 229 (3):264-9. 17. Li J, Li W, Su J, Liu W, Altura BT, Altura BM. Hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells:possible relation to neurodegenerative diseases and strokes. 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The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol 2003,23(1):26-37. 34. Goke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B. Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). Am J Physiol Cell Physiol.2004; 287:C1541-6. 35. Afonja, O., D. Juste, S. Das, S. Matsuhashi, H. H. Samuels. Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis. Oncogene.2004,23:8135-45. 36. Ozpolat, B., U. Akar, M. Steiner, et al. Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol Cancer Res.2007,5:95-108. 37. Szabo C, Ohshima H. DNA damage induced by peroxynitrite:subsequent biological effects. Nitric Oxide.1997;1(5):373-85. 38. Jope R S, Zhang L, Song L. Peroxynitrite modulates the activation of p38 and extracellular regulated kinases in PC 12 cells. Arch Biochem Biophys.2000, 76(2):365-70. 39. Salgo M G, Squadrito G L, Pryor W A. Peroxynitrite causes apoptosis in rat thymocytes. Biochem Biophys Res Commun.1995,215(3):1111-8. 40. Brookes P S. Mitochondrial nitric oxide synthase.Mitochondrion.2004, 3(4):187-204 41. Spear N, Estevez A G, Barbeito L. Nerve growth factor protects PC 12 cells against peroxynitrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase. J Neurochem.1997,69(1):53-9. 42. Boatright K M, Salvesen G S. Mechanisms of caspase activation.Curr Opin Cell Biol,2003,15:725-731 43. Li MH, Cha YN, Surh YJ. Carbon monoxide protects PC 12 cells from peroxynitrite-induced apoptotic death by preventing the depolarization of mitochondrial transmembrane potential. Biochem Biophys Res Commun 2006; 342:984-90. 44. Levrand S, Vannay-Bouchiche C, Pesse B, et al. Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo. Free Radic Biol Med 2006; 41:886-95. 45. Choi JW, Yoo BK, Ryu MK, et al. Adenosine and purine nucleosides prevent the disruption of mitochondrial transmembrane potential by peroxynitrite in rat primary astrocytes. Arch Pharm Res 2005; 28:810-5. 46. Virag L, Szabo C. BCL-2 protects peroxynitrite-treated thymocytes from poly(ADP-ribose) synthase (PARS)-independent apoptotic but not from PARS-mediated necrotic cell death. Free Radic Biol Med 2000; 29:704-13. 47. Arstall MA, Sawyer DB, Fukazawa R, Kelly RA. Cytokine-mediated apoptosis in cardiac myocytes:the role of inducible NO synthase induction and peroxynitrite generation. Circ Res 1999; 85:829-40. 48. Shibahara K, Asano M, Ishida Y, et al. Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Gene.1995;166(2):297-301. 49. Goke A, Goke R, Knolle A, et al. DUG is a novel homologue of translation initiation factor 4G that binds eIF4A. Biochem Biophys Res Commun. 2002;297(1):78-82. 50. Hayashi A, Aishima S, Miyasaka Y, et al. Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas:its association with tumor progression and proliferation. Hum Pathol.2010; 41(11):1507-15. 51. Chang KH, Miller N, Kheirelseid EA,et al. MicroRNA-21 and PDCD4 expression in colorectal cancer. Eur J Surg Oncol.2011,3. 52. Fassan M, Pizzi M, Giacomelli L, et al. PDCD4 nuclear loss inversely correlates with miR-21 levels in colon carcinogenesis. Virchows Arch.2011; 458(4):413-9. 53.Chang JH, Cho YH, Sohn SY, et al. Crystal structure of the eIF4A-PDCD4 complex Proc Natl Acad Sci U S A.2009; 106(9):3148-53. 54.Yangiiez E, Castello A, Welnowska E, et al. Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation. Virology.2011; 413(1):93-102. 55. Suzuki C, Garces RG, Edmonds KA, et al.PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proc Natl Acad Sci USA.2008; 105(9):3274-9. 56. Bohm M, Sawicka K, Siebrasse JP, et al. The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA. Oncogene. 2003;22(31):4905-10 57. Azzoni L, Zatsepina O, Abebe B, et al. Differential transcriptional regulation of CD161 and a novel gene,197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. J Immunol.1998;161(7):3493-500. 58.Yang HS, Knies JL, Stark C, Colburn NH. Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation. Oncogene.2003;22(24):3712-20. 59. Jansen AP, Camalier CE, Stark C, Colburn NH. Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity. Mol Cancer Ther.2004;3(2):103-10. 60..Reis PP, Tomenson M, Cervigne NK, et al. Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma. Mol Cancer.2010; 9:238-50. 61. Afonja O, Juste D, Das S, Matsuhashi S, Samuels HH. Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis. Oncogene.2004; 23(49):8135-45. 62. Gao F, Zhang P, Zhou C, Li J, et al. Frequent loss of PDCD4 expression in human glioma:possible role in the tumorigenesis of glioma. Oncol Rep.2007, 17(1):123-8 63.Lee S, Bang S, Song K, Lee I. Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon. Oncol Rep.2006;16(4):747-54. 64. Zhang H, Ozaki I, Mizuta T, et al. Involvement of programmed cell death 4 in transforming growth factor-betal-induced apoptosis in human hepatocellular carcinoma. Oncogene.2006;25(45):6101-12. 65. Hilliard A, Hilliard B, Zheng SJ, et al. Translational regulation of autoimmune inflammation and lymphoma genesis by p rogrammed cell death 4. J Immunol, 2006,177 (11):8095-102. 66. Stalberg P, Lopez-Egido JR, Wang S, et al. Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line:activation of the human mismatch repair protein 3 gene. Biochem Biophys Res Commun.2001; 281(1):227-31. 67. Loh PG, Yang HS, Walsh MA, et al. Structural basis for translational inhibition by the tumour suppressor Pdcd4. EMBO J.2009;28(3):274-85. 68. Talotta F, Cimmino A, Matarazzo MR, et al. An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation. Oncogene. 2009; 28(1):73-84. 69.. Goke R, Barth P, Schmidt A, et al. Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). Am J Physiol Cell Physiol.2004; 287(6):C1541-6. 70. Lankat-Buttgereit B, Goke R. The tumour suppressor Pdcd4:recent advances in the elucidation of function and regulation. Biol Cell.2009; 101(6):309-17. 71. Jansen A P, Camalier C E, Stark C, Colburn N H. Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity. Mol Cancer Ther.2004,3(2):103-10. 72. Taki, S., Homma, A., Oridate, N., et al. Salvage surgery for local recurrence after chemoradiotherapy or radiotherapy in hypopharyngeal cancer patients. Eur Arch Otorhinolaryngol.2010; 267(11):1765-9 73. Huang WY, Jen YM, Chen CM, et al. Intensity modulated radiotherapy with concurrent chemotherapy for larynx preservation of advanced resectable hypopharyngeal cancer. Radiat Oncol.2010; 5:37-44. 74. Prince ME, Sivanandan R, Kaczorowski A, et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA.2007;104(3):973-8. 75. Klein JD, Grandis JR. 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Mol Cancer. 2010;9:227. [series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [李建峰] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 李建峰 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 100104 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 51539 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => Peroxynitrite;;PDCD4基因;;DDRs基因;;FaDu细胞;;细胞凋亡 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 宋莎莎 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => Peroxynitrite-induced Apoptosis in FaDU Cells is Correlated with the Activities of PDCD4, DDR1 and DDR2 Genes [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => R739.63 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 9 [batch] => 0 [jl_keyword_cn_keyword_en] => fadu细胞,ddrs基因,pdcd4基因,peroxynitrite,细胞凋亡 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 4 [id] => R6tq32YBFjIhTVEb64t2 [tags] => 0 ) [18] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 《抱朴子外篇》是晋代葛洪所撰的一部儒家典籍。葛洪于晋惠帝太安元年(302年)开始草创《外篇》,经十多年努力,至晋元帝建武元年(317年)大体写定。全书共五十卷,内容大致言“人间得失,世事臧否”。本文从词汇角度出发,以《汉语大词典》为主要参照,对《抱朴子外篇》复音词中的新词新义进行了较为系统的梳理和研究。 本论文共分五章。 第一章:引言。主要介绍了葛洪的生平,《抱朴子外篇》的内容、版本,本课题的研究现状、研究内容、研究方法以及研究的价值和意义。 第二章:《抱朴子外篇》复音词的判定标准。在综合前人研究成果的基础上,我们提出了以意义标准为主,形式标准为辅,同时参考频率标准和相关工具书收录情况的方法。 第三章:《抱朴子外篇》复音词新词新义。此章以《汉语大词典》为主要参照,系统全面地考证了《抱朴子外篇》复音词中的全部1253条新词新义。其中新词又分为三个部分:《汉语大词典》首证之新词,计564条;《汉语大词典》书证迟晚之新词,计139条;《汉语大词典》未收之新词,计83条。新义也分为三个部分:《汉语大词典》首证之新义,计383条;《汉语大词典》书证迟晚之新义,计57条;《汉语大词典》未收之新义,计27条。论文后以附表形式详细列出有关新词新义的全部词条。 第四章:《抱朴子外篇》复音词新词新义产生的原因。我们从社会风俗、宗教、人才选拔制度、天文历法、医学、个人因素等角度对《抱朴子外篇》复音词新词新义产生的原因进行了初步探讨。 第五章:结语。为全文之总结。通过对《抱朴子外篇》复音词中1253条新词新义的分析和研究,我们发现其具备三个方面的特点:1.时代性,较为鲜明地反映了两晋时期的社会、生活、语言面貌;2.独创性,有一部分新词新义为其自创;3.规范性,与《抱朴子内篇》相比,呈现出较多的书面语色彩。 《抱朴子外篇》复音词中大量的新词新义为汉语词汇史和汉语史研究提供了翔实的语料资源,也对今后《汉语大词典》的修订工作有一定的参考价值。 [keyword_plu] => [book_alias] => 1011223542.pdf [controlled_terms] => [complete_time] => 2011-05-19 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-19 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 汉语言文字学 [cauthor_ad] => [cscd_No] => [abstract_en] => BaoPuZiWaiPian is an important book about Confucianism,written by Ge Hong in Jin Dynasty.Ge Hong began to write it in the first year of Tai-An of Jin-Hui-Di(302A.D.).He kept on writing for more than ten years, and completed it in the first year of Jian-Wu of Jin-Yuan-Di(317A.D.).There are fifty pieces in it. Its content includes the real affairs of the world. From the lexical aspect departure, this paper focuses on the systematic study of new words and new meanings of disyllabic words in BaoPuZiWaiPian,which are judged by Great Chinese Dictionary. This paper consists of five chapters. The first chapter of the paper introduce the writer GeHong and all his life, BaoPuZiWaiPian's content and the edition,as well as the present situation, content, method, value of research on BaoPuZiWaiPian. The second chapter of the paper refer to the judgement of disyllabic words. We put forward the meaning standards as a primary method,and form standards as a subsidiary method, meanwhile consider the frequency standards and relevant reference book collected. The third chapter is the main chapter in this paper. There are 1253 new words and new meanings of disyllabic words in BaoPuZiWaiPian, so this section just focuses on the systematic study of these new words and new meanings,which are judged by Great Chinese Dictionary. In addition, we divide these new words into three parts:"new words which have been first cited in Great Chinese Dictionary"(total 564); "new words which have been latter cited in Great Chinese Dictionary" (total 139) and"new words which have not been cited in Great Chinese Dictionary" (total 83).We also divide new meanings into three parts:"new meanings which have been first cited in Great Chinese Dictionary" (total 383); "new meanings which have been latter cited in Great Chinese Dictionary" (total 57)and"new meanings which have not been cited in Great Chinese Dictionary" (total 27). In the end of the paper, we list all the words in addendums. The fourth chapter of paper from different aspect to find the reason of appearance of the new words and new meanings. The appearance of these new words and new meanings under the influence of social customs, buddhism, taoism, talents selection institution, medicine, personal factors, astronomy and calendar. The fifth chapter is the conclusion of this paper. Through the analysis and research of new words and new meanings of disyllabic words(total 1253) in BaoPuZiWaiPian, We found it has the characteristics of three aspects:Temporal spirit.It reflects the society, life and language outlook of Jin Dynasty Originality. Part of new words and new meanings derived from the author's innovation spirit; Normalization. Compared with BaoPuZiNeiPian, BaoPuZiWaiPian shows more colour of written language. Lots of new words and new meanings of disyllabic words in BaoPuZiWaiPian provide linguistic data resources for the research of Chinese vocabulary history and Chinese history, and have certain reference function for the revise of Great Chinese Dictionary. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => [page] => 117 [title_cn] => 《抱朴子外篇》复音词新词新义研究 [article_dt] => [name_editor] => [reference] => ①见杨明照《抱朴子外篇校笺·附录》,《外篇》下第795页。 ②见钱穆《葛洪年谱》,原刊1946年12月3日南京《中央日报·文史周刊》第二十九期,后收入其《中国学术思想史论丛》(卷三),安徽教育出版社,2004年7月。 ③见罗宗强《魏晋南北朝文学思想史》,第152页。 ④见杨明照《抱朴子外篇校笺·自叙》,《外篇》下第648页。 ⑤见杨明照《抱朴子外篇校笺·自叙》,《外篇》下第649页。 ⑥见杨明照《抱朴子外篇校笺·自叙》,《外篇》下第665页。 ①见杨明照《抱朴子外篇校笺·自叙》,《外篇》下第655页。 ②见杨明照《抱朴子外篇校笺·附录》,《外篇》下第726页。 ③见王明《抱朴子内篇校释·金丹》,第70页。 ①见杨明照《抱朴子外篇校笺·附录》,《外篇》下第726页。 ②见杨明照《抱朴子外篇校笺·自叙》,《外篇》下第698页。 ③参见庞月光《抱朴子外篇全译》。 ①见杨明照《抱朴子外篇校笺·吴失》,《外篇》下第142页。 ①见杨明照《抱朴子外篇校笺·穷达》,《外篇》下第620页。 ②见孙伏园《鲁迅先生开列的中国文学入门书十二部》中对《抱朴子外篇》的批语。1951年人民文学第四卷第六期。 ①详见杨明照《抱朴子外篇校笺·前言》,第16-17页;庞月光《抱朴子外篇全译》上,第18页。 ②据清严可均《铁桥漫稿》卷六《代继莲龛叙抱朴子校勘记》可知,所谓继昌《抱朴子外篇校勘记》实际上是严可均所作。 ③《札迻》卷十有《抱朴子外篇》校文六则。 ④《读抱朴子》中有《抱朴子外篇》校文十二则。 ⑤《抱朴子校补》铅印本,共44页。第37页至第44页为《抱朴子外篇》校文,共30则。 ①转引自李养正《葛洪评传》,《中国道教》1986年18期。 ①转引自李养正《葛洪评传》,《中国道教》1986年18期。 ①见张双棣《吕氏春秋词汇研究》第171页。 ②见马真《先秦复音词初探》。 ③见程湘清《汉语史专书复音词研究》第41-56页。 ④见周生亚《世说新语中的复音词问题》第81-82页。 ⑤见许威汉《简论汉语复音词》。 ①见毛远明《<左传>词汇研究》第80页。 ②见马真《先秦复音词初探》。 ③本文的写作以中华书局1991年版杨明照先生的《抱朴子外篇校笺》为参照版本,文中所提数、页码均出于该书。 ④见马真《先秦复音词初探》。 ①见马真《先秦复音词初探》。 ②见马真《先秦复音词初探》。 ①见马真《先秦复音词初探》。 ①见杜丽荣《<商君书>实词研究》第210页。 ①见杜丽荣《<商君书>实词研究》第210页。 ②见斯大林《论语言学中的马克思主义》,原苏联《真理报》第171号,1950年6月20日。 ①见董志翘《<入唐求法巡礼行记>词汇研究》第91页。 ②见《汉语大词典》第8卷,竹部,第1221页。 ③见《汉语大词典》第8卷,虍部,第850页。 ①见《汉语大词典》第8卷,竹部,第1225页。 ②见《汉语大词典》第9卷,走部,第1129页。 ③见《汉语大词典》第9卷,纟部,第841页。 ④附表一:《汉语大词典》首证之新词——最早见于《抱朴子外篇》之首证新词。 ⑤附表二:首证之新词——《抱朴子外篇》之前已有用例,但《汉语大词典》作为首证之词条。 ⑥见《汉语大词典》第11卷,隹部,第845页。 ①见《汉语大词典》第12卷,门部,第133页。 ②见《汉语大词典》第6卷,月部,第1264页。 ③见《十三经注疏》第2714页。 ④见《汉语大词典》第11卷,言部,第314页。 ⑤见《汉语大词典》第3卷,口部,第622页。 ⑥见《汉语大词典》第2卷,大部,第1489页。 ①见《汉语大词典》第6卷,手部,第925页。 ②见《汉语大词典》第5卷,水部,第1343页。 ③见《汉语大词典》第8卷,自部,第1328页。 ①见《汉语大词典》第9卷,纟部,第926页。 ②见《汉语大词典》第6卷,月部,第1284页。 ③见《汉语大词典》第3卷,夕部,第1147页。 ①见《汉语大词典》第9卷,艸部,第542页。 ②见《汉语大词典》第3卷,彳部,第927页。 ③见《汉语大词典》第5卷,支部,第455页。 ①见《汉语大词典》第12卷,门部,第136页。 ②见《汉语大词典》第2卷,儿部,第256页。 ③见《汉语大词典》第10卷,贝部,第110页。 ①见《汉语大词典》第11卷,阜部,第1123页。 ②见《汉语大词典》第8卷,禾部,第136页。 ③孙星衍疑作“(?)”,杨明照同。 ④见《汉语大词典》第9卷,走部,第1112页。 ⑤见《汉语大词典》第1卷,人部,第1416页。 ①见《汉语大词典》第9卷,车部,第1311页。 ②见《汉语大词典》第8卷,竹部,第1110页。 ③见《汉语大词典》第7卷,心部,第411页。 ④见《汉语大词典》第6卷,方部,第1607页。 ①见《汉语大词典》第7卷,心部,第451页。 ②见《汉语大词典》第1卷,人部,第1128页。 ③见《汉语大词典》第9卷,米部,第228页。 ④见《汉语大词典》第5卷,水部,第1342页。 ①见《汉语大词典》第7卷,心部,第591页。 ②见《汉语大词典》第4卷,女部,第347页。 ③见《汉语大词典》第5卷,水部,第1325页。 ④见《汉语大词典》第2卷,小部,第1630页。 ①见《汉语大词典》第4卷,木部,第938页。 ②见《汉语大词典》第1卷,人部,第1211页。 ③见《汉语大词典》第3卷,夕部,第1155页。 ④见《汉语大词典》第7卷,火部,第263页。 ⑤杨明照:“菽”字于此与时令不合,疑为“荠”之误。见《抱朴子外篇校笺》下,第299页。 ⑥陈其荣:“郁阴”卢本作“郁隆”。杨明照:藏本、吉藩本、慎本、旧写本、文溯本并作郁隆,未误。见《抱朴子外篇校笺》下,第299页。 ①见《汉语大词典》第8卷,至部,第798页。 ②见《汉语大词典》第5卷,日部,第777页。 ③见《汉语大词典》第3卷,口部,第434页。 ④见《汉语大词典》第8卷,禾部,第154页。 ①见《汉语大词典》第1卷,人部,第1560页。 ②见《汉语大词典》第5卷,日部,第801页。 ③见《汉语大词典》第1卷,人部,第1644页。 ④见《汉语大词典》第7卷,火部,第214页。 ①见《汉语大词典》第1卷,十部,第915页。 ②见《汉语大词典》第11卷,耳部,第1061页。 ③见《汉语大词典》第6卷,水部,第174页。 ④附表三:《汉语大词典》书证迟晚之新词——最早用例为《抱朴子外篇》之新词。 ①见《汉语大词典》第8卷,臣部,第728页。 ②杨明照赞同孙星衍说,认为“敛”当作“杀”。见《抱朴子外篇校笺》上,第81页。 ③见《汉语大词典》,第2卷,又部,第875页。 ④见《汉语大词典》第7卷,户部,第352页。 ①见《汉语大词典》第8卷,禾部,第122页。 ②见《汉语大词典》第4卷,木部,第1366页。 ③见《汉语大词典》第4卷,木部,第893页。 ①见《汉语大词典》第6卷,手部,第894页。 ②见《汉语大词典》第1卷,人部,第1125页。 ③见《汉语大词典》第2卷,冫部,第396页。 ①见《汉语大词典》第12卷,鱼部,第1230页。 ②见《汉语大词典》第4卷,木部,第1334页。 ③见《汉语大词典》第4卷,王部,第602页。 ①见《汉语大词典》第10卷,辵部,第1031页。 ②见《汉语大词典》第2卷,儿部,第268页。 ③附表四:《汉语大词典》书证迟晚之新词——《抱朴子外篇》之前已有用例,但《汉语大词典》首证晚于《抱朴子外篇》之词条。 ①见《抱朴子外篇校笺》上,第469页。 ②三坟,传说中我国最古老的典籍。 ①见《汉语大词典》第4卷,木部,第939页。 ②见《汉语大词典》第4卷,木部,第1156页。 ③杨明照认为“倍”疑在“责”字下,并在“娉”下加豆。见《抱朴子外篇校笺》上,第564页。 ④见《汉语大词典》第9卷,衣部,第107页。 ⑤见《汉语大词典》第4卷,女部,第361页。 ⑥见《抱朴子外篇全译》上,第481页。 ⑦见《抱朴子外篇校笺》上,第562页。 ①附表五:《汉语大词典》未收之新词。 ①见《汉语大词典》第9卷,艸部,第344页。 ②见《汉语大词典》第9卷,艸部,第344页。 ③见《汉语大词典》第9卷,艸部,第450页。 ④见《汉语大词典》第9卷,艸部,第513页。 ⑤见《汉语大词典》第9卷,艸部,第624页。 ⑥附表六:《汉语大词典》首证之新义——最早见于《抱朴子外篇》中之首证新义。 ⑦另见附表七:《汉语大词典》首证之新义——《抱朴子外篇》之前已有用例,但《汉语大词典》作为首证之词义。 ①见《汉语大词典》第5卷,日部,第607页。 ②见《汉语大词典》第8卷,疋部,第507页。 ③见《汉语大词典》第2卷,土部,第1208页。 ①见《汉语大词典》第5卷,水部,第989页。 ②见《汉语大词典》第4卷,木部,第901页。 ③见《汉语大词典》第5卷,水部,第1171页。 ④见《汉语大词典》第2卷,几部,第287页。 ①“凡庸”,汉书作“庸人”。 ②见《汉语大词典》第2卷,寸部,第1249页。 ③见《汉语大词典》第7卷,毋部,第824页。 ④见《汉语大词典》第7卷,心部,第602页。 ⑤见《汉语大词典》第3卷,宀部,第1379页。 ⑥见《十三经注疏》第1808页。 ①见《汉语大词典》第8卷,广部,第366页。 ②见《汉语大词典》第5卷,水部,第1492页。 ③见《汉语大词典》第5卷,水部,第899页。 ④见《汉语大词典》第4卷,木部,第1325页。 ①见《十三经注疏》第80页。 ②见《汉语大词典》第1卷,人部,第1481页。 ③见《汉语大词典》第8卷,白部,第270页。 ④见《汉语大词典》第7卷,心部,第779页。 ①见《汉语大词典》第7卷,心部,第778页。 ②见《汉语大词典》第8卷,竹部,第1285页。 ③见《汉语大词典》第2卷,卩部,第518页。 ④见《抱朴子外篇全译》上,第77页。 ①见《汉语大词典》第5卷,日部,第744页。 ②见《汉语大词典》第5卷,水部,第1298页。 ③见《汉语大词典》第9卷,聿部,第253页。 ④见《汉语大词典》第4卷,弓部,第156页。 ①见《汉语大词典》第一卷,乙部,第801页。 ②见《汉语大词典》第3卷,彳部,第962页。 ③见《汉语大词典》第2卷,冫部,第399页。 ④见《汉语大词典》第3卷,口部,第544页。 ①见《汉语大词典》第11卷,隹部,第903页。 ②见《汉语大词典》第2卷,大部,第1347页。 ③见《汉语大词典》第3卷,宀部,第1555页。 ④见《抱朴子外篇校笺》下,第150页。 ①见《汉语大词典》第1卷,丿部,第634页。 ②见《汉语大词典》第1卷,人部,第1382页。 ③见《汉语大词典》第11卷,金部,第1345页。 ④见《汉语大词典》第6卷,毛部,第1011页。 ①见《汉语大词典》第2卷,勹部,第187页。 ②见《汉语大词典》第12卷,食部,第493页。 ③见《汉语大词典》第1卷,人部,第1613页。 ①附表八:《汉语大词典》书证迟晚之新义——最早用例为《抱朴子外篇》之新义。 ②见《汉语大词典》第4卷,尸部,第25页。 ③见《汉语大词典》第10卷,辵部,第1004页。 ④见《汉语大词典》第8卷,竹部,第1145页。 ①见《汉语大词典》第2卷,又部,第893页。 ②见《汉语大词典》第12卷,食部,第585页。 ③附表九:《汉语大词典》书证迟晚之新义——《抱朴子外篇》之前已有用例,但《汉语大词典》首证晚于《抱朴子外篇》之词义。 ①见《汉语大词典》第9卷,草部,第366页。各义项书证略。下无特殊情况同此。 ②见《抱朴子外篇校笺》上,第4页。 ③见《抱朴子外篇全译》上,第4页。 ④见《汉语大词典》第12卷,鼎部,第1315页。 ⑤见《抱朴子外篇校笺》上,第237页。 ⑥见《汉语大词典》第5卷,水部,第1365页。 ①见《汉语大词典》第10卷,贝部,第81页。 ②见《抱朴子外篇全译》上,第138页。 ③见《汉语大词典》第7卷,心部,第420页。 ④见《汉语大词典》第1卷,人部,第1223页。 ⑤见《汉语大词典》第11卷,隹部,第884页。 ①见《抱朴子外篇校笺》,第623页。 ②见《汉语大词典》第5卷,犬部,第49页。 ③见《汉语大词典》第2卷,几部,第288页。 ④附表十:《汉语大词典》未收之新义。 ①见王明《抱朴子内篇校释》增订本,第149页。 ②“贡举”还有很多用例,不一一列举。 ①见《抱朴子外篇校笺·用刑》,《外篇》上第361页。 ②见《抱朴子外篇校笺·应嘲》,《外篇》下第416页。 ③见《抱朴子外篇校笺·用刑》,《外篇》上第361页。 ①见程湘清《汉语史断代专书研究方法论》,《汉字文化》1991年2期。 1.蔡镜浩.魏晋南北朝词语释例[M].江苏:江苏古籍出版社,1990. 2.陈飞龙.抱朴子外篇今注今译[M].台湾:台湾商务印书馆,2002. 3.程湘清.汉语史专书复音词研究[M].北京:商务印书馆,2003. 4.程湘清.魏晋南北朝汉语研究[M].山东:山东教育出版社,1992. 5.董志翘.《入唐求法巡礼行记》词汇研究[M].北京:中国社会科学出版社,2000. 6.杜丽荣.《商君书》实词研究[M].山东:山东文艺出版社,2010. 7.方一新.东汉魏晋南北朝史书词语笺释.安徽:黄山书社,1997. 8.房玄龄等.晋书[M].北京:中华书局,1974. 9.国学整理社.诸子集成(第八册)[M].北京:中华书局,2006. 10.胡孚琛.魏晋神仙道教——《抱朴子内篇》研究[M].北京:人民出版社,1989. 11.江蓝生.魏晋南北朝小说词语汇释[M].北京:语文出版社,1988. 12.蓝秀隆.抱朴子研究[M].台北: 文津出版社,1980. 13.林丽雪.抱朴子内外篇思想析论[M],台北:台湾学生书局,1980. 14.罗宗强.魏晋南北朝文学思想史[M].北京:中华书局,1996. 15.卢央.葛洪评传[M].南京:南京大学出版社,2006. 16.毛远明.《左传》词汇研究[M].重庆:西南师范大学出版社,1999. 17.潘允中.汉语词汇史概要[M].上海:上海古籍出版社,1989. 18.庞月光.抱朴子外篇全译[M].贵州:贵州人民出版社,1997. 19.钱穆.中国学术思想史论丛[C].安徽:安徽教育出版社,2004. 20.(清)阮元.十三经注疏[M].北京:中华书局,1980. 21.孙诒让.札迻[M].北京:中华书局,1989. 22.汤可敬.说文解字今释[M].湖南:岳麓书社,1997. 23.王明.抱朴子内篇校释(增订本)[M].北京:中华书局,1985. 24.王利器.葛洪论[M].台北:五南图书出版社公司,1997. 25.王云路、方一新.中古汉语语词例释[M].吉林:吉林教育出版社,1992. 26.(东汉)许慎.说文解字[M].北京:中华书局,1963. 27.杨明照.抱朴子外篇校笺[M].北京:中华书局,1991. 28.张双棣.《吕氏春秋》词汇研究[M].济南:山东教育出版社,1g89. 29.周一良.魏晋南北朝史札记[M].北京:中华书局,1985. 1.成妍.《抱朴子内篇》词汇研究[D].南京师范大学硕士论文,2005. 2.程喜霖.葛洪生卒年及隐居罗浮考[J].武汉大学学报,1982,(6) 3.程湘清.汉语史断代专书研究方法论[J].汉字文化,1991,(2). 4.丁宏武.《抱朴子》外篇的成书及思想倾向[J].甘肃社会文学,2004,(2). 5.董玉芝.《抱朴子》复音词词义简论[J].新疆教育学院学报,1996,(3). 6.董玉芝.《抱朴子》复音词构词方法初探[J].古汉语研究,1994,(4). 7.董玉芝.《抱朴子》联合式复音词研究[J].新疆教育学院学报,1994,(1). 8.董玉芝.《抱朴子》偏正式复音词研究[J].新疆教育学院学报,1995,(4). 9.董玉芝.《抱朴子》特指义拾零[J].新疆教育学院学报,2004,(4). 10.董玉芝.《抱朴子》同义词拾零[J].新疆教育学院学报,2006,(4). 11.董玉芝.《抱朴子》同义词拾零(二)[J].新疆教育学院学报,2008,(1). 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4.四部丛刊(电子版).北京书同文数字化技术有限公司. [series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [邵文利] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 邵文利 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 50103 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 49571 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => 《抱朴子外篇》;;复音词;;新词新义;;《汉语大词典》 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 李井卉 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => The Study of New Words and New Meanings of Disyllabic Words in BaoPuZiWaiPian [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => H131 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 0 [batch] => 0 [jl_keyword_cn_keyword_en] => 新词新义,抱朴子外篇,复音词,汉语大词典 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 4 [id] => N6tr32YBFjIhTVEbKpME [tags] => 0 ) [19] => Array ( [grant_bulletin_date] => [abstract_meeting] => [delivery_No] => [producer] => [ei_No] => [discipline_name] => [isbn] => [main_cword] => [abstract_cn] => 本文研究了在Kahneman和Tversky提出的预期理论和彭实戈提出的g期望的框架下的最优投资策略选择问题。本文模型建立在连续时间情形下并且首次采用非线性g期望去取代文献[1]中的Choquet期望,依据预期理论的原则用S型的分段效用函数去表示投资者对待收益和损失时不同的效用态度,以g期望作为对概率扭曲的替代方式。这些使得该优化问题非常复杂的同时也使得问题非常有意义。本文把完全市场中的财富运作方程由线性扩展到超线性,这样可以把更多现实的情形囊括到模型中,如对多头和空头风险补偿系数不同的情形等。虽然模型在形式和结构上复杂繁琐,但最优解的形式非常简洁,是两类不同期权的组合。我们发现当模型中所有的g函数都是线性情形时,最优解的形式类似于[1]的结论,但有本质的区别。最后我们具体计算了分段CRRA效用函数下的优化模型,得出最优未定权益求解出最优投资策略并对符号背后的经济含义给出解释,极大的增强了模型的现实意义。 [keyword_plu] => [book_alias] => 1011228545.pdf [controlled_terms] => [complete_time] => 2011-04-20 00:00:00 [imf] => [publisher_city] => [uncontrolled_terms] => [conference_ad] => [subsection] => [cite_awos] => [imf_once] => [classification_pub] => [publication_iso ] => [oral_time] => 2011-05-20 00:00:00 [main_eword] => [awards_type] => [bulletin_No] => [publication_29] => [pub_year] => 2011 [eissn] => [dom_ranking] => [application_date] => [from_id] => 79 [profession_stu] => 金融数学与金融工程 [cauthor_ad] => [cscd_No] => [abstract_en] => This paper solves the optimal portfolio selection model under the frame-work of the prospect theory proposed by Kahneman and Tversky in 1970s and the g-expectation by peng. This model was established in the general continuous time setting and firstly adopted the g-expectation to replace the nonlinear expectation, for example the choquet expectation in [1]. Using different S-shaped utility functions to represent the investors'different at-titudes towards losses and gains, distorting the objectively probability in the form of g-expectation, these not only make the model more realistic but also more difficult to deal with. We deduce the wealth equation in complete market from linear in [1] to super-linear case which will incorporate more realistic cases, for example the risk premium different for the short and long positions. Although the models are mathematically complicated and sophisticated, the optimal solution turns out to be surprisingly simple:the payoff of a portfolio of two binary options. Also we find that our optimal solution has the similar form with the one in [1] when all the g functions are the same linear case, but they are different in essence. At last, we solve out an concrete example with CRRA utility function finding out the opti-mal investment strategy and find the economic meaning behind the symbols which greatly enhance the application of our model. [document_No] => [institution_type] => [imf_5] => [attachment_text] => [top_article] => [student_No] => [page] => 48 [title_cn] => 预期理论和g-期望下的最优投资策略选择问题 [article_dt] => [name_editor] => [reference] => [1]Hanqing Jin and Xun Yu Zhou. Behavioral portfolio selection in con-tinuous time. SIAM J. CONTROL OPTIM,Vol.37,No.3,pp.825-843. [2]ShiGe Peng and Zhen Wu, Fully coupled forward-backward stochas-tic differential equations and applications to optimal control. SIAM J. CONTROL OPTIM,Vol.37,No.3,pp.825-843. [3]N.EL KAROUI S.Peng and M.C.QUENEZ, Backward stochastic differ-ential equations in finance. Mathematical Finance, Vol.7,No.l(January 1997),1-71. [4]ShaoLin Ji and Xun Yu Zhou, A maximum principle for s-tochastic optimal control with terminal state constraints, and its applications. COMMUNICATIONS IN INFORMATION AND SYSTERMS.Vol.6,No.4,pp.321-338,2006. [5]ShaoLin Ji and ShiGe Peng, Terminal perturbation method for the backward approach to continuous time mean-variance portfolio se-lection. STOCHASTIC PROCESSES And THEIR APPLICATIONS. 118(2008)952-967 [6]Jaksa Cvitanic and Jin Ma, Hedging options for a large investor and forward-backward SDE's. The annals of applied probability. 1996,Vol.6,No.2,370-398. [7]H. Markowitz, Portfolio selection. J. Finance.7 (1952) 77-91. [8]D. Li, W.L. Ng, Optimal dynamic portfolio selection:Multiperiod mean variance formulation. Math. Finance.10 (2000) 387-406 [9]T.R.Bielecki,H.Jin,S.R Pliska and X.Y.Zhou, Continuous time mean variance portfolio selection with bankruptcy prohibition Math.Finance,15(2005),pp.213-214 [10]N.E1 Karoui,S.Peng.and M.C.Quenez, A dynamic maximum princi-ple for the optimization of recursive utilities under constraints. An-n.Appl.Prob. 11(2001),pp.664-693 [11]S.R.Pliska, A discrete time stochastic decision model. Advances in Filtering and Optimal Stochastic Control, edited byW.H.Fleming and L.G Gorostiza, Lecture Notes in Control and Information Sciences,42, Springer-Verlag,New York,290-304,1982 [12]Chen, Z. and Sulem, A. A representation theorem of g-expectation. INRIA.4284. [13]Chen,Z.,Kulperger,R. Minimax pricing and choquet pricing. In-sur.Math.Econ.38,518-528(2006) [14]Choquet,F.,Hu,Y.,Memin,J.,Peng,S, Filtration consistent nonlinear ex-pectations and related g-expectation. Probab. Theory relat Fields. 123,1-27(2002) [15]ShaoLin Ji and Xun Yu Zhou, A Generalized Neyman-Pearson Lemma for g-Probabilities. ACT A AUTOMATIC A SINICA. Vol.32,No.2,March,2006. [16]D.Cuoco,J.Cvitanic, Optimal consumption choices for a "large" investor. J.Econom.Dynam. Control.22(1998) 401-436. [17]Shige PENG, Modeling derivatives pricing mechanism with their gen-erating functions, may (2006) [18]E.Pardoux,S.Peng,, Adapted solution of a Backward stochastic differ-ential equations. System, Control Lett.14(1990)55-61. [19]A.B.Berkelaar,R.kouwenberg and T.Post(2004) Optimal portfolio choice under loss aversion. Rev.Econ.Stat.86,pp.973-987. [20]Xuedong He and Xunyu Zhou(2010) Portfolio Choice Under Cumu-lative Prospect Theory:An Analytical Treatment. MANAGEMENT SCIENCEVol.57, No.2, February 2011, pp.315-331 [21]Xuedong He and Xunyu Zhou(2009) Portfolio Choice via quantiles. Mathematical Finance Volume 21, Issue 2, pages 203- 231, April 2011 [series] => [fund_type] => [create_time] => [research_area] => [sponsor] => [awards_title ] => [publication_type] => [fund_No] => [highly_article] => [cssci_No] => [cite_wos] => [author_jg] => [嵇少林] [issue] => [email] => [datebase] => [degree] => 硕士 [name_tutor1] => 嵇少林 [cauthor_back] => [begin_page] => [publisher] => [language] => 中文; [author_fn] => [country] => [pubmedID] => [author_in] => [check_3Y] => [subject_gb1] => 20204 [jcr_wos] => [wos_No] => [standard_in] => [cauthor] => [author_gro] => [scopus_No] => [bulletin_date] => [author_en] => [job_no] => [volume_label] => 52853 [clc] => [abstract_type] => [fund_CSSCI] => [conference] => [keyword_cn] => g期望;;预期理论;;动态定价机制;;S型效用函数;;CRRA效用函数 [article_id] => [suppl] => [editor] => [thesis_au] => [conference_pro] => [email_c] => [author_first] => [conference_spo] => [volume] => [phone] => [publisher_ad] => [check_180] => [end_page] => [author_cn] => 李波 [researcherID] => [fund_ab] => [department_tutor1] => [reference_No] => [publication_cn] => [cite_scopus] => [special_is] => [student_type] => [institution_first] => [tag] => 20 [publication_en] => [conference_data] => [legal_status] => [open_time] => [agency] => [isbn_10] => [hx_id] => 0 [province] => [numerical_index] => [meet_code] => 10422 [school_stu] => [title_en] => The Optimal Portfolio Selection Model under Prospect Theory and g-expectation [wos_sub] => [source_type] => 353 [birthday] => [keyword_en] => [pub_date] => [pages] => [fund_amount] => [positional_titles] => [doi] => [classification_No] => F224;F830.59 [issn] => [institution_name] => 山东大学 [uri] => [responsibility] => [orcID] => [grant_bulletin_No] => [jl_language] => 中文 [author_test] => Array ( ) [sys_author_id_arr] => [batch2] => 5 [sys_jg_type] => 9 [batch] => 0 [hb_type] => 2 [company_id] => 0,0,0,0,0,0,0 [author_id] => [sys_author_id] => [hints] => 3 [id] => Qatq32YBFjIhTVEbv4Zn [tags] => 0 ) ) 1-->
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