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IL12A signal enhances efficacy of sorafenib plus NK cells immunotherapy to better suppress HCC progression (2016) Mol Cancer Ther, 15, pp. 731-742; Miura, K., Ishioka, M., Minami, S., Horie, Y., Ohshima, S., Goto, T., Toll-like receptor 4 on macrophage promotes the development of steatohepatitis-related hepatocellular carcinoma in mice (2016) J Biol Chem, 291, pp. 11504-11517; Miura, K., Ohnishi, H., Role of gut microbiota and toll-like receptors in nonalcoholic fatty liver disease (2014) World J Gastroenterol, 20, pp. 7381-7391; Dapito, D.H., Mencin, A., Gwak, G.Y., Pradere, J.P., Jang, M.K., Mederacke, I., Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4 (2012) Cancer Cell, 21, pp. 504-516; Li, W., Xiao, J., Zhou, X., Xu, M., Hu, C., Xu, X., STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma (2015) J Clin Invest, 125, pp. 4239-4254; Uthaya Kumar, D.B., Chen, C.L., Liu, J.C., Feldman, D.E., Sher, L.S., French, S., TLR4 signaling via NAnoG cooperates with STAT3 to activate twist1 and promote formation of tumor-initiating stem-like cells in livers of mice (2016) Gastroenterology, 150, pp. 707-719; Sepehri, Z., Kiani, Z., Kohan, F., Alavian, S.M., Ghavami, S., Toll like receptor 4 and hepatocellular carcinoma; a systematic review (2017) Life Sci, 179, pp. 80-87; Lin, A., Wang, G., Zhao, H., Zhang, Y., Han, Q., Zhang, C., TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells (2016) Oncoimmunology, 5, p. e1074376; Shi, G., Wang, C., Zhang, P., Ji, L., Xu, S., Tan, X., Donor polymorphisms of toll-like receptor 4 rs1927914 associated with the risk of hepatocellular carcinoma recurrence following liver transplantation (2017) Arch Med Res, 48, pp. 553-560; Xu, D., Han, Q., Hou, Z., Zhang, C., Zhang, J., MiR-146a negatively regulates NK cell functions via STAT1 signaling (2017) Cell Mol Immunol, 14, pp. 712-720; Lan, P., Zhang, C., Han, Q., Zhang, J., Tian, Z., Therapeutic recovery of hepatitis b virus (HBV)-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance (2013) Hepatology, 58, pp. 73-85; Shalini, S., Nikolic, A., Wilson, C.H., Puccini, J., Sladojevic, N., Finnie, J., Caspase-2 deficiency accelerates chemically induced liver cancer in mice (2016) Cell Death Differ, 23, pp. 1727-1736; Wang, Y., Cai, J., Zeng, X., Chen, Y., Yan, W., Ouyang, Y., Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis b virus-related hepatocellular carcinoma via ERK1/2 signaling (2015) BMC Cancer, 15, p. 821; Hartwell, H.J., Petrosky, K.Y., Fox, J.G., Horseman, N.D., Rogers, A.B., Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-myc in mice (2014) Proc Natl Acad Sci U S A, 111, pp. 11455-11460; van de Wijngaart, D.J., Dubbink, H.J., van Royen, M.E., Trapman, J., Jenster, G., Androgen receptor coregulators: Recruitment via the coactivator binding groove (2012) Mol Cell Endocrinol, 352, pp. 57-69; Heemers, H.V., Tindall, D.J., Androgen receptor (AR) coregulators: A diversity of functions converging on and regulating the AR transcriptional complex (2007) Endocr Rev, 28, pp. 778-808; Shi, L., Yan, P., Liang, Y., Sun, Y., Shen, J., Zhou, S., Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma (2017) Cell Death Dis, 8, p. e3171; Shi, L., Lin, H., Li, G., Sun, Y., Shen, J., Xu, J., Cisplatin enhances NK cells immunotherapy efficacy to suppress HCC progression via altering the androgen receptor (AR)-ULBP2 signals (2016) Cancer Lett, 373, pp. 45-56; Jiang, X., Kanda, T., Nakamoto, S., Miyamura, T., Wu, S., Yokosuka, O., Involvement of androgen receptor and glucose-regulated protein 78 kda in human hepatocarcinogenesis (2014) Exp Cell Res, 323, pp. 326-336; Ngo, H.K.C., Kim, D.H., Cha, Y.N., Na, H.K., Surh, Y.J., Nrf2 mutagenic activation drives hepatocarcinogenesis (2017) Cancer Res, 77, pp. 4797-4808; Lin, S.J., Chou, F.J., Li, L., Lin, C.Y., Yeh, S., Chang, C., Natural killer cells suppress enzalutamide resistance and cell invasion in the castration resistant prostate cancer via targeting the androgen receptor splicing variant 7 (ARv7) (2017) Cancer Lett, 398, pp. 62-69; Cheng, M.A., Chou, F.J., Wang, K., Yang, R., Ding, J., Zhang, Q., Androgen receptor (AR) degradation enhancer ASC-J9((R)) in an FDA-approved formulated solution suppresses castration resistant prostate cancer cell growth (2018) Cancer Lett, 417, pp. 182-191 [format_title_en_publication_en_pub_year] => 6f56bdad5a2e3529eb4394694f4b5f1e456480166 [abstract_en] => Background: Androgen receptor (AR) has a role in regulating malignancies and gender disparities in hepatocellular carcinoma (HCC). Recently, TLR4 activation is demonstrated to be required for HCC progression; however, whether and how TLR4 interacts with AR is largely unknown.; Methods: The tumorigenesis was detected in female and male mice induced by DEN/CCL4, then TLR4 and AR signals were detected in liver tissues by qPCR and FACS. The proliferation, colony formation and migration of HCC cell treated with TLR4 agonist LPS, or/and androgen DHT were evaluated in vitro. Furthermore, the expression of TLR4 and AR was detected by IHC in tissue microarray of HCC, and correlation of AR and TLR4 was defined.; Results: Male mice are more susceptible to develop HCC than female mice. Meanwhile, we found baseline TLR4 levels were higher in male mice than in female mice. AR expression in male mice was increased by treatment with DEN/CCL4. And, AR was constitutively expressed in human HCC cell lines. Dihydrotestosterone (DHT) stimulated TLR4 expression in both HepG2 and HepG2 2.15 cells, which could be blocked by silencing AR. On the other hand, treatment with LPS stimulated AR expression, but it was blocked by treatment with TLR4 antagonist and in cells deficient for TLR4. DHT treatment exacerbated TLR4-induced cellular proliferation, colony formation, migration, and invasion of HepG2 cells. The positive relationship between AR and TLR4 was confirmed in human HCC samples.; Conclusions: DHT-AR-TLR4 signaling enhances the development of HCC cells and facilitates their migration and invasion, demonstrating a mechanism underlying gender disparity in HCC. [scopus_id] => 55416640400;57213836522;57204707893;36018041700; [from_id] => 76,73 [cauthor_ad] => [Zhang, J]Shandong Univ, Sch Pharmaceut Sci, Inst Immunopharmaceut Sci, Jinan 250012, Shandong, Peoples R China. [hx_id] => 2378,2371 [doi] => 10.7150/jca.30682 [datebase] => Scopus [sys_level_num] => 15_6 [sys_jg_type] => 11 [format_issn_issue_page_pub_year] => 1673065a8cc6ffc1db822699bcaaa4e0-1925113239 [title_en] => Androgen Receptor (AR)-TLR4 Crosstalk Mediates Gender Disparities in Hepatocellular Carcinoma Incidence and Progression [index_keyword] => androgen receptor; androstanolone; carbon tetrachloride; lipopolysaccharide; messenger RNA; toll like receptor 4; animal cell; animal experiment; animal model; animal tissue; Article; cancer growth; cancer incidence; carcinogenesis; cell invasion; cell migration; cell proliferation; colony formation; controlled study; female; fluorescence activated cell sorting; human; human tissue; immunofluorescence test; liver cell; liver cell carcinoma; liver tissue; male; mouse; nonhuman; protein expression; real time polymerase chain reaction; sex difference; tissue microarray; Western blotting [volume] => 11 [source_type] => 351 [pub_year] => 2020 [keyword_en] => AR; Gender bias; TLR4; Hepatocellular Carcinoma [article_id] => 819421,812476 [begin_page] => 1094 [hints] => 9 [publisher] => IVYSPRING INT PUBL [substance] => androstanolone, 521-18-6; carbon tetrachloride, 56-23-5; toll like receptor 4, 203811-83-0 [language] => English [issue] => 5 [issn] => 1837-9664 [batch] => 3422,3424 [publication_en] => JOURNAL OF CANCER [email] => zhangj65@sdu.edu.cn [sys_update_time] => 2020-03-13 09:56:09 [format_title_en_issn_pub_year] => d6e8382dbb08ac734048c1de2d619426150854751 [publication_iso] => J. Cancer [SYS_TAG] => 3 [end_page] => 1103 [page] => 1094-1103 [hb_type] => 2 [article_dt] => Article [hb_batch] => grant_no [cite_wos] => 0 [check_3Y] => 0 [delivery_No] => JW1OU [format_title] => [author_fn] => Han, Qiuju; Yang, Dan; Yin, Chunlai; Zhang, Jian [pages] => 10 [publication_29] => J CANCER [open_type] => DOAJ Gold, Green Published [pubmedID] => 31956356 [publication_type] => J [get_data] => 2020-03-06 [format_publication_cn] => [keyword_plu] => RESISTANT PROSTATE-CANCER; NK CELLS IMMUNOTHERAPY; HEPATITIS-B-VIRUS; ACTIVATION; HCC; COREGULATORS; MICROBIOTA; PROMOTES; EFFICACY [fund_ab] => This work was supported Shandong Provincial Key Research and Development; Program [grant number 2017GSF18159] and Shandong Provincial Natural; Science Foundation, China [grant number ZR2017BH029] and the Fundamental; Research Fund of Shandong University (2017JC004). 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[reference] => Avis, D., A revised implementation of the reverse search vertex enumeration algorithm (2000) Polytopes—Combinatorics and Computation, Oberwolfach, 1997, DMV Sem., 29, pp. 177-198. , Birkhäuser Basel; Bachoc, C., Venkov, B., Modular forms, lattices and spherical designs (2001) Réseaux euclidiens, designs sphériques et formes modulaires, Monogr. Enseign. Math., 37, pp. 87-111. , Enseignement Math. Geneva; Bosma, W., Cannon, J., Playoust, C., The Magma algebra system. I. The user language (1997) Computational Algebra and Number Theory, J. Symbolic Comput., 24 (3-4), pp. 235-265. , London, 1993; Cohn, H., Elkies, N., New upper bounds on sphere packings. I (2003) Ann. of Math. (2), 157 (2), pp. 689-714; Cohn, H., Kumar, A., Optimality and uniqueness of the Leech lattice among lattices (2009) Ann. of Math. 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Math., 8, pp. 241-250; Martinet, J., Perfect Lattices in Euclidean Spaces (2003) Grundlehren der Mathematischen Wissenschaften, 327. , Fundamental Principles of Mathematical Sciences Springer-Verlag Berlin; Mittelmann, H.D., Vallentin, F., High-accuracy semidefinite programming bounds for kissing numbers (2010) Exp. Math., 19 (2), pp. 175-179; Nebe, G., Nossek, E., Venkov, B., Low dimensional strongly perfect lattices. II: dual strongly perfect lattices of dimension 13 and 15 (2013) J. Théor. Nombres Bordeaux, 25 (1), pp. 147-161; Nebe, G., Sloane, N., A catalogue of lattices (2019), http://www.math.rwth-aachen.de/~Gabriele.Nebe/LATTICES/; Nebe, G., Venkov, B., The strongly perfect lattices of dimension 10 (2000) Colloque International de Théorie des Nombres, J. Théor. Nombres Bordeaux, 12 (2), pp. 503-518. , Talence, 1999; Nebe, G., Venkov, B., Low-dimensional strongly perfect lattices. I. The 12-dimensional case (2005) Enseign. Math. (2), 51 (1-2), pp. 129-163; Nebe, G., Venkov, B., Low-dimensional strongly perfect lattices. III. Dual strongly perfect lattices of dimension 14 (2010) Int. J. Number Theory, 6 (2), pp. 387-409; Nossek, E., Dual Strongly Perfect Lattices (2013), PhD thesis RWTH Aachen; Scharlau, R., Hemkemeier, B., Classification of integral lattices with large class number (1998) Math. Comp., 67 (222), pp. 737-749; Scharlau, W., Quadratic and Hermitian Forms (1985) Grundlehren der Mathematischen Wissenschaften, 270. , Fundamental Principles of Mathematical Sciences Springer-Verlag Berlin; Schürmann, A., Perfect, strongly eutactic lattices are periodic extreme (2010) Adv. Math., 225 (5), pp. 2546-2564; Siegel, C.L., Gesammelte Abhandlungen. Bände I (1966), Herausgegeben von K. Chandrasekharan und H. Maass Springer-Verlag Berlin-New York; The Sage Developers, SageMath, the Sage Mathematics Software System (Version 8.7) (2019), https://www.sagemath.org; Venkov, B., Réseaux et designs sphériques (2001) Réseaux euclidiens, designs sphériques et formes modulaires, Monogr. Enseign. Math., 37, pp. 10-86. , Enseignement Math. Geneva; Walling, L.H., A remark on differences of theta series (1994) J. Number Theory, 48 (2), pp. 243-251; Yang, T., An explicit formula for local densities of quadratic forms (1998) J. Number Theory, 72 (2), pp. 309-356 [format_title_en_publication_en_pub_year] => 7bba64854bdd7c638b5c3d1cb8e2a90c-858015068 [abstract_en] => We classify the dual strongly perfect lattices in dimension 16. There are four pairs of such lattices, the famous Barnes-Wall lattice Lambda(16), the extremal 5-modular lattice N-16, the odd Barnes-Wall lattice O-16 and its dual, and one pair of new lattices Gamma(16) and its dual. The latter pair belongs to a new infinite series of dual strongly perfect lattices, the sandwiched Barnes-Wall lattices, described by the authors in a previous paper. An updated table of all known strongly perfect lattices up to dimension 26 is available in the catalogue of lattices [15]. (C) 2019 Elsevier Inc. All rights reserved. [scopus_id] => 55209028200;57203519377; [from_id] => 76,73 [cauthor_ad] => [Nebe, G]Rhein Westfal TH Aachen, Lehrstuhl Math, Aachen, Germany. [hx_id] => 2378,2371 [classification_pub] => JNUTA [datebase] => Scopus [sys_level_num] => 15_6 [sys_jg_type] => 11,3 [title_en] => Low dimensional strongly perfect lattices IV: The dual strongly perfect lattices of dimension 16 [volume] => 208 [source_type] => 351 [pub_year] => 2020 [keyword_en] => Strongly perfect lattices; Spherical designs; Modular forms; Locally; densest lattices [article_id] => 819983,810551 [begin_page] => 262 [hints] => 7 [publisher] => ACADEMIC PRESS INC ELSEVIER SCIENCE [doi] => 10.1016/j.jnt.2019.08.001 [language] => English [issn] => 0022-314X [batch] => 3422,3424 [publication_en] => JOURNAL OF NUMBER THEORY [email] => husihuang@gmail.com; nebe@math.rwth-aachen.de [sys_update_time] => 2020-03-13 09:56:09 [format_title_en_issn_pub_year] => 62ea7e1f000883e1c1e4e7063950e4631229093723 [publication_iso] => J. Number Theory [SYS_TAG] => 3 [end_page] => 294 [page] => 262-294 [hb_type] => 2 [article_dt] => Article [hb_batch] => grant_no [cite_wos] => 0 [fund_No] => Alexander von Humboldt FoundationAlexander von Humboldt Foundation [check_3Y] => 1 [delivery_No] => JR6VD [format_title] => [author_fn] => Hu, Sihuang; Nebe, Gabriele [pages] => 33 [publication_29] => J NUMBER THEORY [eissn] => 1096-1658 [publication_type] => J [get_data] => 2020-03-06 [format_publication_cn] => [keyword_plu] => BOUNDS [fund_ab] => Humboldt fellow supported by the Alexander von Humboldt Foundation. [format_title_en] => 990c97a62208b2ac8c68e9aa08099121-311370558 [publisher_city] => SAN DIEGO [pub_date] => MAR [cauthor_order] => 2 [reference_No] => 27 [cite_awos] => 0 [wos_No] => WOS:000499759700012 [sys_priority_field] => 73 [format_wos_No] => 4612c11a14216a52a3a1e4b582a191b01684029208 [wos_sub] => Mathematics [research_area] => Mathematics [cauthor_back] => Nebe, G [check_180] => 1 [publisher_ad] => 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA [format_publication_en] => ee402113033b74b76eb8d4c4df2dd16b1429255428 [jl_language] => english [jl_article_dt] => 期刊论文 [jl_publication_en] => journalofnumbertheory [jl_country] => 中国 [jl_keyword_en] => stronglyperfectlattices,sphericaldesigns,modularforms,densestlattices,locally [sys_author_in_last_arr] => peoplesrchina [jl_publisher] => academicpressincelsevierscience [company_id] => 0 [author_id] => [id] => 2wA003ABe-eYmRwwyAWA [tags] => 0 ) [14] => Array ( [standard_in] => Boston Children’s Hospital, Boston, MA, United States; Department of Cardiovascular Surgery, Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China; Masonic Medical Research Institute, Utica, NY, United States; Department of Critical Care Medicine, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, China; Boston Children’s Hospital, Dana Farber Cancer Institute, Boston, MA, United States; Houston Methodist Research Institute, Houston, TX, United States; Harvard Stem Cell Institute, Cambridge, MA, United States [cauthor] => Pu, WT(wpu@pulab.org) [school_id] => 117 [scopus_No] => 2-s2.0-85076701625 [batch2] => 15 [uri] => https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076701625&doi=10.26508%2flsa.201900424&partnerID=40&md5=e36438c926852cb72240fcb94d768542 [tag] => 0 [author_en] => Chen, JM; Ma, Q; King, JS; Sun, Y; Xu, B; Zhang, XY; Zohrabian, S; Guo, HP; Cai, WQ; Li, G; Bruno, I; Cooke, JP; Wang, CS; Kontaridis, M; Wang, DZ; Luo, HB; Pu, WT; Lin, ZQ [publication_en] => LIFE SCIENCE ALLIANCE [format_scopus_No] => 59ef6803109f42c5149b08382e134d3b1273305989 [format_doi] => 78cf1e6c10cdff199bf4f60f355202721870137050 [sys_update_time] => 2020-03-13 09:56:10 [fund_No] => China Scholarship CouncilChina Scholarship Council; American Heart; Association Scientist Development GrantAmerican Heart Association; [15SDG25590001]; Progenitor Cell Biology Consortium \"JUMP START\" AWARDS; [5U01HL099997-07]; National Institutes of HealthUnited States Department; of Health & Human ServicesNational Institutes of Health (NIH) - USA; [HL138454-01, R01 HL116461] [reference] => Breuer, K., Foroushani, A.K., Laird, M.R., Chen, C., Sribnaia, A., Lo, R., Winsor, G.L., Lynn, D.J., InnateDB: Systems biology of innate immunity and beyond–recent updates and continuing curation (2013) Nucleic Acids Res, 41, pp. D1228-D1233; Carlsson, L., Clarke, J.C., Yen, C., Gregoire, F., Albery, T., Billger, M., Egnell, A.C., Johansson, E., Biocompatible, purified VEGF-A mRNA improves cardiac function after intracardiac injection 1 week post-myocardial infarction in swine (2018) Mol Ther Methods Clin Dev, 9, pp. 330-346; Chia, S., Nagurney, J.T., Brown, D.F., Raffel, O.C., Bamberg, F., Senatore, F., Wackers, F.J., Jang, I.K., Association of leukocyte and neutrophil counts with infarct size, left ventricular function and outcomes after percutaneous coronary intervention for ST-elevation myocardial infarction (2009) Am J Cardiol, 103, pp. 333-337; 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We and others previously showed that sustained expression of the transcriptional co-activator yes-associated protein (YAP) improves survival and myocardial outcome after myocardial infarction. Here, we asked whether transient YAP expression would improve myocardial outcome after IR injury. After IR, we transiently activated YAP in the myocardium with modified mRNA encoding a constitutively active form of YAP (aYAP mod RNA). Histological studies 2 d after IR showed that aYAP modRNA reduced cardiomyocyte (CM) necrosis and neutrophil infiltration. 4 wk after IR, aYAP modRNA-treated mice had better heart function as well as reduced scar size and hypertrophic remodeling. In cultured neonatal and adult CMS, YAP attenuated H2O2- or LPS-induced CM necrosis. TLR signaling pathway components important for innate immune responses were suppressed by YAP/TEAD1. In summary, our findings demonstrate that aYAP mod RNA treatment reduces CM necrosis, cardiac inflammation, and hypertrophic remodeling after IR stress. [scopus_id] => 56512891200;42961996100;57212452349;57212455699;57212445206;57212460001;55180777200;55323136900;57212452571;57212446250;7003982560;57212444003;55684065900;6506697579;55713256600;57212449141;7004057741;54997318400; [from_id] => 76,73 [cauthor_ad] => [Pu, WT; Lin, ZQ]Boston Childrens Hosp, Boston, MA 02115 USA@@@[Lin, ZQ]Masonic Med Res Inst, Utica, NY 13501 USA@@@[Pu, WT]Harvard Stem Cell Inst, Cambridge, MA 02138 USA. [hx_id] => 2378,2371 [datebase] => Scopus [sys_level_num] => 15_6 [sys_jg_type] => 11 [title_en] => aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model [author_in] => [Chen, Jinmiao; Ma, Qing; King, Justin S.; Zhang, Xiaoyu; Zohrabian, Sylvia; Guo, Haipeng; Cai, Wenqing; Li, Gavin; Wang, Da-Zhi; Luo, Hongbo; Pu, William T.; Lin, Zhiqiang] Boston Childrens Hosp, Boston, MA 02115 USA.@@@ [Chen, Jinmiao; Wang, Chunsheng] Fudan Univ, Zhongshan Hosp, Dept Cardiovasc Surg, Shanghai, Peoples R China.@@@ [Chen, Jinmiao; Wang, Chunsheng] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai, Peoples R China.@@@ [Sun, Yan; Xu, Bing; Kontaridis, Maria; Lin, Zhiqiang] Masonic Med Res Inst, Utica, NY 13501 USA.@@@ [Guo, Haipeng] Shandong Univ, Dept Crit Care Med, Key Lab Cardiovasc Remodeling & Funct Res, Qilu Hosp,Chinese Minist Educ, Jinan, Peoples R China.@@@ [Guo, Haipeng] Shandong Univ, Chinese Minist Hlth, Qilu Hosp, Jinan, Peoples R China.@@@ [Cai, Wenqing] Dana Farber Canc Inst, Boston, MA 02115 USA.@@@ [Bruno, Ivone; Cooke, John P.] Houston Methodist Res Inst, Houston, TX USA.@@@ [Pu, William T.] Harvard Stem Cell Inst, Cambridge, MA 02138 USA. [volume] => 3 [source_type] => 351 [pub_year] => 2020 [article_id] => 812881,818962 [hints] => 8 [publisher] => LIFE SCIENCE ALLIANCE LLC [doi] => 10.26508/lsa.201900424 [language] => English [issue] => 1 [issn] => 2575-1077 [batch] => 3422,3424 [pubmedID] => 31843959 [email] => wpu@pulab.org; zlin@mmri.edu [document_No] => e201900424 [format_title_en_issn_pub_year] => 58c006946235fd876470b678b1b62ec1555784353 [publication_iso] => Life Sci. Alliance [SYS_TAG] => 3 [hb_type] => 2 [article_dt] => Article [hb_batch] => grant_no [cite_wos] => 0 [check_3Y] => 2 [delivery_No] => KI6FW [format_title] => [author_fn] => Chen, Jinmiao; Ma, Qing; King, Justin S.; Sun, Yan; Xu, Bing; Zhang, Xiaoyu; Zohrabian, Sylvia; Guo, Haipeng; Cai, Wenqing; Li, Gavin; Bruno, Ivone; Cooke, John P.; Wang, Chunsheng; Kontaridis, Maria; Wang, Da-Zhi; Luo, Hongbo; Pu, William T.; Lin, Zhiqiang [pages] => 14 [publication_29] => LIFE SCI ALLIANCE [open_type] => DOAJ Gold, Green Published [eissn] => 2575-1077 [orcID] => Chen, Jinmiao/0000-0003-4326-0665; King, Justin/0000-0002-6469-9872 [publication_type] => J [get_data] => 2020-03-06 [format_publication_cn] => [keyword_plu] => TOLL-LIKE RECEPTORS; HIPPO-YAP; CARDIOMYOCYTE PROLIFERATION; OXIDATIVE STRESS; INNATE IMMUNITY; INJURY; RNA; PATHWAY; MYOCARDIUM; INFARCTION [fund_ab] => We thank Alexander Von Gise from the University of Hannover for; critically reviewing the manuscript. Sources of Funding: J Chen was; supported by a Scholarship Fund from China Scholarship Council. Z Lin; was supported by American Heart Association Scientist Development Grant; 15SDG25590001, Progenitor Cell Biology Consortium \"JUMP START\" AWARDS,; 5U01HL099997-07, and National Institutes of Health HL138454-01. WT Pu; was supported by National Institutes of Health R01 HL116461. [format_title_en] => d308af64c30e6b5622a7ba647d087c96-1334878267 [publisher_city] => COLD SPRING HARBOR [pub_date] => JAN [cauthor_order] => 17,18,18,17 [reference_No] => 61 [cite_awos] => 0 [wos_No] => WOS:000511446200007 [sys_priority_field] => 73 [format_wos_No] => a535831d20f4344195bf9596f7698fae1812122121 [wos_sub] => Biology [research_area] => Life Sciences & Biomedicine - Other Topics [cauthor_back] => Pu, WT@@@Lin, ZQ@@@Lin, ZQ@@@Pu, WT [check_180] => 2 [publisher_ad] => 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA [format_publication_en] => 6aa048f4fea0f40c4850bab859787781542684007 [jl_language] => english [jl_article_dt] => 期刊论文 [jl_publication_en] => lifesciencealliance [jl_country] => 中国 [sys_author_in_last_arr] => ma02115usa,peoplesrchina [jl_publisher] => lifesciencealliancellc [company_id] => 0,210 [author_id] => [sys_subject_sort] => 0 [college_parent_id] => 210 [company_test] => Array [id] => ewA003ABe-eYmRww6AsC [tags] => 0 ) [15] => Array ( [standard_in] => Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China; Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, Shandong, 250012, China; Key Laboratory of Endocrine and Metabolic Diseases, Shandong Province Medicine and Health, Jinan, Shandong, 250012, China [cauthor] => Liu, F(liufuqiang@sdu.edu.cn) [school_id] => 117 [scopus_No] => 2-s2.0-85079159674 [author_in] => [Wang, Jiajia; Li, Wenjuan; Wang, Chuan; Wang, Lingshu; He, Tianyi; Hu, Huiqing; Song, Jia; Cui, Chen; Qiao, Jingting; Qing, Li; Li, Lili; Zang, Nan; Wang, Kewei; Wu, Chuanlong; Qi, Lin; Ma, Aixia; Zheng, Huizhen; Hou, Xinguo; Liu, Fuqiang; Chen, Li] Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250012, Shandong, Peoples R China.@@@ [Wang, Jiajia; Li, Wenjuan; Wang, Chuan; Wang, Lingshu; He, Tianyi; Hu, Huiqing; Song, Jia; Cui, Chen; Qiao, Jingting; Qing, Li; Li, Lili; Zang, Nan; Wang, Kewei; Wu, Chuanlong; Qi, Lin; Ma, Aixia; Zheng, Huizhen; Hou, Xinguo; Liu, Fuqiang; Chen, Li] Shandong Univ, Inst Endocrine & Metab Dis, Jinan 250012, Shandong, Peoples R China.@@@ [Wang, Jiajia; Li, Wenjuan; Wang, Chuan; Wang, Lingshu; He, Tianyi; Hu, Huiqing; Song, Jia; Cui, Chen; Qiao, Jingting; Qing, Li; Li, Lili; Zang, Nan; Wang, Kewei; Wu, Chuanlong; Qi, Lin; Ma, Aixia; Zheng, Huizhen; Hou, Xinguo; Liu, Fuqiang; Chen, Li] Shandong Prov Med & Hlth, Key Lab Endocrine & Metab Dis, Jinan 250012, Shandong, Peoples R China. [batch2] => 15 [uri] => https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079159674&doi=10.1155%2f2020%2f6047145&partnerID=40&md5=3fb5814890475482deb3f11db5916472 [tag] => 0 [author_en] => Wang, JJ; Li, WJ; Wang, C; Wang, LS; He, TY; Hu, HQ; Song, J; Cui, C; Qiao, JT; Qing, L; Li, LL; Zang, N; Wang, KW; Wu, CL; Qi, L; Ma, AX; Zheng, HZ; Hou, XG; Liu, FQ; Chen, L [publication_en] => JOURNAL OF DIABETES RESEARCH [format_scopus_No] => 68e8344734e4265529691047c8b120cc1825631037 [format_doi] => 5e7c7cd1b1404992ce8e0a43a08bb92d-257872275 [sys_update_time] => 2020-03-13 09:56:09 [reference] => Larsen, N., Vogensen, F.K., Berg, F.W.V.D., Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults (2010) PLoS One, 5 (2). , article e9085; Qin, J., Li, Y., Cai, Z., A metagenome-wide association study of gut microbiota in type 2 diabetes (2012) Nature, 490 (7418), pp. 55-60; Wang, X., Xu, X., Xia, Y., Further analysis reveals new gut microbiome markers of type 2 diabetes mellitus (2017) Antonie van Leeuwenhoek, 110 (3), pp. 445-453; Sohail, M.U., Althani, A., Anwar, H., Rizzi, R., Marei, H.E., Role of the gastrointestinal tract microbiome in the pathophysiology of diabetes mellitus (2017) Journal Diabetes Research, 2017, p. 9. , article 9631435; Yamaguchi, Y., Adachi, K., Sugiyama, T., Association of intestinal microbiota with metabolic markers and dietary habits in patients with type 2 diabetes (2016) Digestion, Vol. 94, (2), pp. 66-72; Karlsson, F.H., Tremaroli, V., Nookaew, I., Gut metagenome in European women with normal, impaired and diabetic glucose control (2013) Nature, 498 (7452), pp. 99-103; Sato, J., Kanazawa, A., Ikeda, F., Gut dysbiosis and detection of \"live gut bacteria\" in blood of Japanese patients with type 2 diabetes (2014) Diabetes Care, 37 (8), pp. 2343-2350; Wu, X., Ma, C., Han, L., Molecular characterisation of the faecal microbiota in patients with type II diabetes (2010) Current Microbiology, 61 (1), pp. 69-78; Ussar, S., Griffin, N.W., Bezy, O., Interactions between gut microbiota, host genetics and diet modulate the predisposition to obesity and metabolic syndrome (2015) Cell Metabolism, 22 (3), pp. 516-530; Vrieze, A., Nood, E.V., Holleman, F., Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome (2012) Gastroenterology, 143 (4), pp. 913-916. , , e7; Kovatcheva-Datchary, P., Nilsson, A., Akrami, R., Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella (2015) Cell Metabolism, 22 (6), pp. 971-982; Everard, A., Lazarevic, V., Derrien, M., Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice (2011) Diabetes, 60 (11), pp. 2775-2786; Forslund, K., Hildebrand, F., Nielsen, T., Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota (2015) Nature, 528 (7581), pp. 262-266; Zhang, F., Wang, M., Yang, J., Response of gut microbiota in type 2 diabetes to hypoglycemic agents (2019) Endocrine, 66 (3), pp. 485-493; Zhang, X., Shen, D., Fang, Z., Human gut microbiota changes reveal the progression of glucose intolerance (2013) PLoS One, 8 (8). , article e71108; Arumugam, M., Raes, J., Pelletier, E., Enterotypes of the human gut microbiome (2011) Nature, 473 (7346), pp. 174-180; Ding, T., Schloss, P.D., Dynamics and associations of microbial community types across the human body (2014) Nature, 509 (7500), pp. 357-360; Zhou, Y., Mihindukulasuriya, K.A., Gao, H., Exploration of bacterial community classes in major human habitats (2014) Genome Biology, 15 (5), p. 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Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation (1998) Diabetic Medicine, 15 (7), pp. 539-553; Levy, J.C., Matthews, D.R., Hermans, M.P., Correct homeostasis model assessment (HOMA) evaluation uses the computer program (1998) Diabetes Care, 21 (12), pp. 2191-2192; Cani, P.D., Bibiloni, R., Knauf, C., Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice (2008) Diabetes, 57 (6), pp. 1470-1481; Cani, P.D., Amar, J., Iglesias, M.A., Metabolic endotoxemia initiates obesity and insulin resistance (2007) Diabetes, 56 (7), pp. 1761-1772; Turnbaugh, P.J., Bäckhed, F., Fulton, L., Gordon, J.I., Dietinduced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome (2008) Cell Host & Microbe, 3 (4), pp. 213-223; Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V., Mardis, E.R., Gordon, J.I., An obesity-associated gut microbiome with increased capacity for energy harvest (2006) Nature, 444 (7122), pp. 1027-1031; Sedighi, M., Razavi, S., Navab-Moghadam, F., Comparison of gut microbiota in adult patients with type 2 diabetes and healthy individuals (2017) Microbial Pathogenesis, 111, pp. 362-369; Rampelli, S., Schnorr, S.L., Consolandi, C., Metagenome sequencing of the Hadza hunter-gatherer gut microbiota (2015) Current Biology, 25 (13), pp. 1682-1693 [format_title_en_publication_en_pub_year] => 80e9784a5f7dd36f67e74158cb171977-426643687 [abstract_en] => Background. More and more studies focus on the relationship between the gastrointestinal microbiome and type 2 diabetes, but few of them have actually explored the relationship between enterotypes and type 2 diabetes. Materials and Methods. We enrolled 134 patients with type 2 diabetes and 37 nondiabetic controls. The anthropometric and clinical indices of each subject were measured. Fecal samples of each subject were also collected and were processed for 16S rDNA sequencing. Multiple logistic regression analysis was used to determine the associations of enterotypes with type 2 diabetes. Multiple linear regression analysis was used to explore the relationship between lipopolysaccharide levels and insulin sensitivity after adjusting for age, BMI, TG, HDL-C, DAO, and TNF-alpha. The correlation analysis between factors and microbiota was identified using Spearman correlation analysis. The correlation analysis between factors was identified using partial correlation analysis. Results. Gut microbiota in type 2 diabetes group exhibited lower bacterial diversity compared with nondiabetic controls. The fecal communities from all subjects clustered into two enterotypes distinguished by the levels of Bacteroides and Prevotella. Logistic regression analysis showed that the Bacteroides enterotype was an independent risk factor for type 2 diabetes by decreasing insulin sensitivity. The levels of lipopolysaccharide and tumor necrosis factor-alpha were higher in the Bacteroides enterotype compared to the Prevotella enterotype. Partial correlation analysis showed that lipopolysaccharide was closely associated with diamine oxidase, tumor necrosis factor-alpha, and Gutt insulin sensitivity index after adjusting for multiple covariates. Furthermore, the level of lipopolysaccharide was found to be an independent risk factor for insulin sensitivity. Conclusions. We identified two enterotypes, Bacteroides and Prevotella, among all subjects. Our results showed that the Bacteroides enterotype was an independent risk factor for type 2 diabetes, which was due to increased levels of lipopolysaccharide causing decreased insulin sensitivity. [scopus_id] => 57214806109;57201905386;56165967400;56288899000;56131242900;57208336325;57211967367;57195352356;57195354665;57195352956;57211537186;57214804197;57214793207;55655679100;56395973700;55991621800;57213454675;16312358600;57157647500;57022294500; [from_id] => 76,73 [cauthor_ad] => [Liu, FQ; Chen, L]Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250012, Shandong, Peoples R China@@@[Liu, FQ; Chen, L]Shandong Univ, Inst Endocrine & Metab Dis, Jinan 250012, Shandong, Peoples R China@@@[Liu, FQ; Chen, L]Shandong Prov Med & Hlth, Key Lab Endocrine & Metab Dis, Jinan 250012, Shandong, Peoples R China. [hx_id] => 2378,2371 [doi] => 10.1155/2020/6047145 [datebase] => Scopus [sys_level_num] => 15_6 [sys_jg_type] => 11,3 [title_en] => Enterotype Bacteroides Is Associated with a High Risk in Patients with Diabetes: A Pilot Study [index_keyword] => amine oxidase (copper containing); DNA 16S; high density lipoprotein cholesterol; insulin; lipopolysaccharide; triacylglycerol; tumor necrosis factor; adult; anthropometric parameters; Article; Bacteroides; body mass; controlled study; diabetic patient; disease association; DNA sequence; high risk patient; human; insulin sensitivity; intestine flora; major clinical study; microbial community; microbial diversity; non insulin dependent diabetes mellitus; nonhuman; pilot study; Prevotella [volume] => 2020 [source_type] => 351 [pub_year] => 2020 [article_id] => 819291,813520 [hints] => 8 [publisher] => HINDAWI LTD [substance] => amine oxidase (copper containing), 9001-53-0, 9014-75-9; insulin, 9004-10-8 [language] => English [issn] => 2314-6745 [batch] => 3422,3424 [pubmedID] => 32064276 [email] => wangjj20120503@163.com; 43910083@qq.com; 1175533920@qq.com;; lingshu_wang@163.com; htylucia@163.com; huhuiqing93@163.com;; songjia11264@163.com; 1359883392@qq.com; 286860339@qq.com;; 774171315@qq.com; 1127052171@qq.com; 632560877@qq.com;; 17865192050@163.com; wclwby@126.com; qilincx@126.com; max7194@163.com;; zhenghuizhen1@163.com; houxinguo@sdu.edu.cn; liufuqiang@sdu.edu.cn;; chenli3@medmail.com.cn [document_No] => 6047145 [format_title_en_issn_pub_year] => 47467edd204ee7fc158acc6a9f90578b661298248 [publication_iso] => J. Diabetes Res. [SYS_TAG] => 3 [hb_type] => 2 [article_dt] => Article [hb_batch] => grant_no [cite_wos] => 0 [fund_No] => National Natural Science Foundation of ChinaNational Natural Science; Foundation of China [81670706, 81873632, 81770818]; National Key; Research and Development Program of China [2016YFC0901204,; 2018YFC1311801]; Taishan Scholars Project [ts201712089]; Youth; Foundation of National Natural Science Foundation of China [81400814] [check_3Y] => 0 [delivery_No] => KH8AS [format_title] => [author_fn] => Wang, Jiajia; Li, Wenjuan; Wang, Chuan; Wang, Lingshu; He, Tianyi; Hu, Huiqing; Song, Jia; Cui, Chen; Qiao, Jingting; Qing, Li; Li, Lili; Zang, Nan; Wang, Kewei; Wu, Chuanlong; Qi, Lin; Ma, Aixia; Zheng, Huizhen; Hou, Xinguo; Liu, Fuqiang; Chen, Li [pages] => 11 [publication_29] => J DIABETES RES [open_type] => DOAJ Gold, Green Published [eissn] => 2314-6753 [publication_type] => J [get_data] => 2020-03-06 [format_publication_cn] => [keyword_plu] => DIET-INDUCED OBESITY; GUT MICROBIOTA; INTESTINAL MICROBIOTA; METAGENOME; GLUCOSE; METABOLISM; MARKERS [fund_ab] => This study was supported by grants from the National Natural Science; Foundation of China (No. 81670706, No. 81873632, and No. 81770818); the; National Key Research and Development Program of China (2016YFC0901204; and 2018YFC1311801); Taishan Scholars Project (ts201712089); and the; Youth Foundation of National Natural Science Foundation of China; (81400814). We thank LetPub (http://www.letpub.com) for its linguistic; assistance during the preparation of this manuscript. [format_title_en] => 08cfad1fe02260c21eb94d5a218922941412263754 [publisher_city] => LONDON [pub_date] => JAN 22 [cauthor_order] => 19,20,19,20,19,20 [reference_No] => 29 [cite_awos] => 0 [wos_No] => WOS:000510872000003 [sys_priority_field] => 73 [format_wos_No] => 7a47ab6a463ca3ce320da4b656902b051435571393 [wos_sub] => Endocrinology & Metabolism; Medicine, Research & Experimental [research_area] => Endocrinology & Metabolism; Research & Experimental Medicine [cauthor_back] => Liu, FQ@@@Chen, L@@@Liu, FQ@@@Chen, L@@@Liu, FQ@@@Chen, L [check_180] => 0 [publisher_ad] => ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND [format_publication_en] => 5f4fd8b747a828bd39fa62a76640ef61494744999 [jl_language] => english [jl_article_dt] => 期刊论文 [jl_publication_en] => journalofdiabetesresearch [jl_country] => 中国 [sys_author_in_last_arr] => peoplesrchina [jl_publisher] => hindawiltd [company_id] => 0 [author_id] => 20277,20281,20280,21906 [author_test] => Array ( [0] => Array ( [sure] => 0 [irmagnum] => 0 [u_index] => 2 [name] => 李文娟 [irtag] => 7 [t_index] => 0 [person_id] => 21906 ) [1] => Array ( [sure] => 0 [irmagnum] => 0 [u_index] => 20 [name] => 陈立 [irtag] => 7 [t_index] => 20 [person_id] => 20277 ) [2] => Array ( [sure] => 0 [irmagnum] => 0 [u_index] => 20 [name] => 陈莉 [irtag] => 7 [t_index] => 20 [person_id] => 20281 ) [3] => Array ( [sure] => 0 [irmagnum] => 0 [u_index] => 20 [name] => 陈利 [irtag] => 7 [t_index] => 20 [person_id] => 20280 ) ) [id] => wwA003ABe-eYmRww6AwC [tags] => 0 ) [16] => Array ( [standard_in] => Department of Hand and Foot Surgery, Linyi Central Hospital, Linyi, China; Department of Respiration, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China; Surgical Intensive Care Unit, Shandong Provincial Chest Hospital, Jinan, China; Respiratory and Critical Medical Ward 7, Shandong Provincial Chest Hospital, Jinan, China [cauthor] => Zhang, J(zhagnjingjing1103@163.com) [school_id] => 117 [scopus_No] => 2-s2.0-85075750576 [batch2] => 15 [uri] => https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075750576&doi=10.1002%2fjcb.28199&partnerID=40&md5=547b6dcb3ccb314f47983275d3d33ea2 [tag] => 0 [author_en] => Zhang, YY; Liu, X; Zhang, XJ; Zhang, JJ [publication_en] => JOURNAL OF CELLULAR BIOCHEMISTRY [format_scopus_No] => fd8959553bd87926bd50c61431fd16cf-328600917 [format_doi] => 35fa7caf42ce77af404e70f261303cca198614998 [author_in] => [Zhang, Ying Ying] Linyi Cent Hosp, Dept Hand & Foot Surg, Linyi, Shandong, Peoples R China.@@@ [Liu, Xue] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Respirat, Jinan, Shandong, Peoples R China.@@@ [Zhang, Xiaojie] Shandong Prov Chest Hosp, Surg Intens Care Unit, Jinan, Shandong, Peoples R China.@@@ [Zhang, Jingjing] Shandong Prov Chest Hosp, Resp & Crit Med Ward 7, Jinan 250013, Shandong, Peoples R China. [reference] => Rubenfeld, G.D., Epidemiology of acute lung injury (2003) Crit Care Med, 31 (4), pp. 276-284; Zhang, X., Song, K., Xiong, H., Li, H., Chu, X., Deng, X., Protective effect of florfenicol on acute lung injury induced by lipopolysaccharide in mice (2009) Int Immunopharma, 9 (13-14), pp. 1525-1529; Matthay, M.A., Zimmerman, G.A., Esmon, C., Future research directions in acute lung injury summary of a national heart lung and blood institute working group (2003) Am J Respir Crit Care Med, 167 (7), pp. 1027-1035; Chen, Z., Zhang, X., Chu, X., Preventive effects of Valnemulin on lipopolysaccharide-induced acute lung injury in mice (2010) Inflammation, 33 (5), pp. 306-314; Chowdhury, P., Sacks, S.H., Sheerin, N.S., Toll-like receptors TLR2 and TLR4 initiate the innate immune response of therenal tubular epithelium to bacterial products (2006) Clin ExpImmunol, 145 (2), pp. 346-356; Lu, Y.C., Yeh, W.C., Ohashi, P.S., LPS/TLR4 signal transduction pathway (2008) Cytokine, 42 (2), pp. 145-151; Wang, Y.P., Wu, Y., Li, L.Y., Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-kappa B and MAPKs in BV2 microglial cells (2011) J Neuroinflammation, 8, p. 95; Chen, X., Yang, L., Oppenheim, J.J., Howard, O.M.Z., Cellular pharmacology studies of shikonin derivatives (2002) Phytother Res, 16, pp. 199-209; Wang, R., Yin, R., Zhou, W., Xu, D., Li, S., Shikonin and its derivatives: a patent review (2012) Expert Opin Ther Pat, 22, pp. 977-997; Shindo, S., Hosokawa, Y., Hosokawa, I., Ozaki, K., Matsuo, T., Shikonin inhibits inflammatory cytokine production in human periodontal ligament cells (2016) Inflammation, 39, pp. 1124-1129; Yang, K.Y., Chen, D.L., Shikonin inhibits inflamatory response in rheumatoid arthritis synovial fibroblasts via lncRNA-NR024118 (2015) Evid Based Complement Alternat Med, 2015; Gan, L., Wang, Z.H., Zhang, H., Protective effects of shikonin on brain injury induced by carbon ion beam irradiation in mice (2015) Biomed Environ Sci, 28, pp. 148-151; Yang, Y., Wang, J., Yang, Q., Shikonin inhibits the lipopolysaccharide-induced release of HMGB1 in RAW264.7 cells via IFN and NF-κB signaling pathways (2014) Int Immunopharmacol, 19, pp. 81-87; Andújar, I., Ríos, J., Giner, R., Recio, M., Pharmacological properties of shikonin — a review of literature since 2002 (2013) Planta Med, 79, pp. 1685-1697; Ghosh, N., Ghosh, R., Bhat, Z.A., Advances in herbal medicine for treatment of ischemic brain injury (2014) Nat Prod Commun, 9 (7), pp. 1045-1055; Tili, E., Michaille, J.J., Cimino, A., Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-α stimulation and their possible roles in regulating the response to endotoxin shock (2007) J Immunol, 179 (8), pp. 5082-5089; Liu, J., Wang, H.Z., Sun, Y., Inhibition of CXCR4 by microRNA-1192 reduces the activation of Th17 cells and expression of inflammation factors in a mouse model of Vulvovaginal candidiasis (2018) Cell Physiol Biochem, 50 (3), pp. 893-910; Rovira-Llopis, S., Escribano-Lopez, I., Diaz-Morales, N., Downregulation of miR-31 in diabetic nephropathy and its relationship with inflammation (2018) Cell Physiol Biochem, 50 (3), pp. 1005-1014; O\'neill, L.A.J., Dinarello, C.A., The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense (2000) Immunol Today, 21 (5), pp. 206-209; Knapp, S., Florquin, S., Golenbock, D.T., van der Poll, T., Pulmonary lipopolysacecharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo (2006) J Immunol, 176 (5), pp. 3189-3195; Chen, H., Bai, C., Wang, X., The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine (2010) Expert Rev Respir Med, 4 (6), pp. 773-783; Rao, Z., Wang, S., Bunner, W.P., Chang, Y., Shi, R., Exercise induced right ventricular fibrosis is associated with myocardial damage and inflammation (2018) Korean Circ J, 48 (11), pp. 1014-1024; Taylor, R.A., Sansing, L.H., Microglial responses after ischemic stroke and intracerebral hemorrhage (2013) Clin Dev Immunol, 2013, pp. 746068-746010; Das, S., Das, D., Anti-inflammatory responses of resveratrol (2007) Inflamm Allergy Drug Targets, 6 (3), pp. 168-173; Akira, S., Takeda, K., Toll-like receptor signaling (2004) Nat Rev Immunol, 4 (7), pp. 499-511 [format_title_en_publication_en_pub_year] => 9f0fe50d798ca01bd9206f8dab56400a-883078688 [abstract_en] => Shikonin is an anti-inflammatory agent extracted from natural herbs. The aim of this study is to explain the treatment effects and mechanism of Shikonin in acute lung injury induced by sepsis. In this study, first, we evaluate different Shikonin concentrations for the anti-inflammation of acute lung injury induced by sepsis in an in vivo study. On the basis of the results, we confirm that 50.0 mg/kg was the best therapeutic Shikonin concentration. As a second step, we discuss the mechanism of Shikonin by a vitro cell experiment. Finaly, we validate that Shikonin has effective treatment effects on acute lung injury via regulation of microRNA-140-5p/toll-like receptor 4 (miRNA-140-5p/TLR4) in the in vivo study. The results of vitro and vivo study showed that Shikonin could improve acute lung injury induced by sepsis. The mechanism might be correlation miRNA-140-5p expression increasing, and regulated targeted gene TLR4, with TLR4 expression depressing, the downstream myeloid differentiation protein 88 and nuclear factor kappa B proteins expression were suppressed. In conclusion, Shikonin improved sepsis induced lung injury by regulation miRNA-140-5p/TLR4. [scopus_id] => 57210325989;57212021240;57212026358;57212019243; [from_id] => 76,73 [cauthor_ad] => [Zhang, JJ]Shandong Prov Chest Hosp, Resp & Crit Med Ward 7, Jinan 250013, Shandong, Peoples R China. [hx_id] => 2378,2371 [classification_pub] => JCEBD [datebase] => Scopus [sys_level_num] => 15_6 [sys_jg_type] => 11 [format_issn_issue_page_pub_year] => 4f09b31e3daeb9c06a10c60b76f06407501778554 [title_en] => Shikonin improve sepsis-induced lung injury via regulation of miRNA-140-5p/TLR4-a vitro and vivo study [volume] => 121 [source_type] => 351 [pub_year] => 2020 [keyword_en] => lung injury; microRNA-140-5p (miRNA-140-5p); myeloid differentiation; protein 88 (MyD88); nuclear factor kappa B (NF-kappa B); Shikonin;; toll-like receptor 4 (TLR4) [article_id] => 811442,820046 [begin_page] => 2103 [hints] => 6 [publisher] => WILEY [doi] => 10.1002/jcb.28199 [language] => English [issue] => 3 [issn] => 0730-2312 [batch] => 3422,3424 [pubmedID] => 31769066 [email] => zhagnjingjing1103@163.com [sys_update_time] => 2020-03-13 09:56:09 [format_title_en_issn_pub_year] => df86835ae36bc3e92fdd0a19e5060906-1833989336 [publication_iso] => J. Cell. Biochem. [SYS_TAG] => 3 [end_page] => 2117 [page] => 2103-2117 [hb_type] => 2 [article_dt] => Article [hb_batch] => grant_no [cite_wos] => 0 [check_3Y] => 0 [delivery_No] => KC6SN [format_title] => [author_fn] => Zhang, Ying Ying; Liu, Xue; Zhang, Xiaojie; Zhang, Jingjing [pages] => 15 [open_type] => Bronze, Other Gold [publication_29] => J CELL BIOCHEM [eissn] => 1097-4644 [publication_type] => J [get_data] => 2020-03-06 [format_publication_cn] => [keyword_plu] => INFLAMMATION; RECEPTORS [format_title_en] => 95798f934a5049c8af5bbcb567decd0f-1537882916 [publisher_city] => HOBOKEN [pub_date] => MAR [cauthor_order] => 4 [reference_No] => 25 [cite_awos] => 0 [wos_No] => WOS:000498412800001 [sys_priority_field] => 73 [format_wos_No] => eea866a927a690d851a55786b4e667f11160175821 [wos_sub] => Biochemistry & Molecular Biology; Cell Biology [research_area] => Biochemistry & Molecular Biology; Cell Biology [cauthor_back] => Zhang, JJ [check_180] => 0 [publisher_ad] => 111 RIVER ST, HOBOKEN 07030-5774, NJ USA [format_publication_en] => 2e14c3bddaac3eb2f0297c3f6e121c4a-598768746 [jl_language] => english [jl_article_dt] => 期刊论文 [jl_publication_en] => journalofcellularbiochemistry [jl_country] => 中国 [jl_keyword_en] => ,myeloiddifferentiation,lunginjury,nuclearfactorkappabnfkappab,microrna1405pmirna1405p,shikonin,tolllikereceptor4tlr4,protein88myd88 [sys_author_in_last_arr] => peoplesrchina [jl_publisher] => wiley [company_id] => 0,0 [author_id] => [id] => GgA003ABe-eYmRwwyAaA [tags] => 0 ) [17] => Array ( [standard_in] => School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255000, China [cauthor] => Sun, X(sunxiuyu@sdut.edu.cn) [school_id] => 117 [scopus_No] => 2-s2.0-85077693980 [batch2] => 15 [uri] => https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077693980&doi=10.1002%2fslct.201903959&partnerID=40&md5=04d4dfc14cef6d056c4e64328662e6ac [tag] => 0 [author_en] => Li, CX; Wang, Y; Zhang, Y; Wang, M; Sun, XY; Cui, HY; Xie, YJ [format_scopus_No] => c9bb58f3b39aae5ee6792e3814e71b7f930390 [format_doi] => 9313da6cc455262d7d3d8aec085e7df2-1556989900 [author_in] => [Li, Chunxiao; Wang, Yong; Zhang, Yuan; Wang, Ming; Sun, Xiuyu; Cui, Hongyou; Xie, Yujiao] Shandong Univ Technol, Sch Chem & Chem Engn, Zibo 255000, Peoples R China. [fund_No] => National Natural Science Foundations of ChinaNational Natural Science; Foundation of China [21978158, 21476132]; Public Welfare Category of Key; R&D Programs in Shandong Province [2018GGX107003]; Natural Science; Foundation of Shandong ProvinceNatural Science Foundation of Shandong; Province [ZR2018BB062] [reference] => Acharjee, T.C., Lee, Y.Y., (2018) Environ. Prog. Sustain. Energy, 37, pp. 471-480; Zhang, X., Murria, P., Jiang, Y., Xiao, W., Kenttämaa, H.I., Abu-Omar, M.M., Mosier, N.S., (2016) Green Chem., 18, pp. 5219-5229; Atanda, L., Mukundan, S., Shrotri, A., Ma, Q., Beltramini, J., (2015) ChemCatChem, 7, pp. 781-790; Osatiashtiani, A., Lee, A.F., Granollers, M., Brown, D.R., Olivi, L., Morales, G., Melero, J.A., Wilson, K., (2015) ACS Catal., 5, pp. 4345-4352; Guo, J., Zhu, S., Cen, Y., Qin, Z., Wang, J., Fan, W., (2017) Appl. Catal. B, 200, pp. 611-619; Yi, G., Teong, S.P., Zhang, Y., (2015) ChemSusChem, 8, pp. 1151-1155; Yang, L., Yan, X., Xu, S., Chen, H., Xia, H., Zuo, S., (2015) RSC Adv., 5, pp. 19900-19906; Hou, Q., Zhen, M., Liu, L., Chen, Y., Huang, F., Zhang, S., Li, W., Ju, M., (2018) Appl. Catal. B, 224, pp. 183-193; Galaverna, R., Breitkreitz, M.C., Pastre, J.C., (2018) ACS Sustainable Chem. Eng., 6, pp. 4220-4230; Wang, J., Zhang, Y., Wang, Y., Zhu, L., Cui, H., Yi, W., (2016) J. Fuel Heat Technol., 44, pp. 1341-1348; Zhu, L., Wang, J., Zhao, P., Song, F., Sun, X., Wang, L., Cui, H., Yi, W., (2017) J. Fuel Heat Technol., 45, pp. 651-659; Dehkordi, A.M., Tehrany, M.S., Safari, I., (2009) Ind. Eng. Chem. Res., 48, pp. 3271-3278; Lee, H.S., Hong, J., (2000) J. Biotechnol., 84, pp. 145-153; Yu, D., Wu, H., Zhang, A., Tian, L., Liu, L., Wang, C., Fang, X., (2011) Process Biochem., 46, pp. 599-603; Despax, S., Estrine, B., Hoffmann, N., Le Bras, J., Marinkovic, S., Muzart, J., (2013) Catal. 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Mater. Sci., 52, pp. 628-642; Delidovich, I., Palkovits, R., (2014) Catal. Sci. Technol., 4, pp. 4322-4329; Lee, G., Jeong, Y., Takagaki, A., Jung, J.C., (2014) J. Mol. Catal. A: Chem., 393, pp. 289-295; Yabushita, M., Shibayama, N., Nakajima, K., Fukuoka, A., (2019) ACS Catal., 9, pp. 2101-2109; Carraher, J.M., Fleitman, C.N., Tessonnier, J.P., (2015) ACS Catal., 5, pp. 3162-3173; Moreau, C., Durand, R., Roux, A., Tichit, D., (2000) Appl. Catal., A, 193, pp. 257-264; Yang, Q., Sherbahn, M., Runge, T., (2016) ACS Sustain. Chem. Eng., 4, pp. 3526-3534 [format_title_en_publication_en_pub_year] => 6b0f59ab2aecfe3452e76d244c3cb388-1392747783 [abstract_en] => Mg-Al hydrotalcites for catalyzing glucose isomerization to fructose are prepared. Effects of atom ratios of Mg/Al ranging from 1 to 4 and calcination temperatures from 250-650 degrees C on catalytic performance were examined systematically. It was found that the hydrotalcite (Mg2Al1LDH) calcined at 450 degrees C with an atom ratio of Mg/Al=2 is an excellent catalyst for glucose isomerization. Characterizations by SEM, EDS, TEM, XRD, FTIR, TG and BET demonstrated that the formed oxide condensed phase as well as the interaction with the alumina helps promote glucose isomerization reaction due to their appropriate basic sites at high calcination temperature. With Mg2Al1-450 as the catalyst, kinetic model analysis confirmed that the reaction of glucose isomerization to fructose was an exothermal reversible reaction; both the forward and reverse reactions are quasi-first-order reactions with activation energies of 71.82 kJ/mol and 48.15 kJ/mol, respectively, while the side reaction is a zero-order reaction with an activation energy of 94.22 kJ/mol. Therefore, high isomerization reaction temperature is not beneficial to enhance the yield and selectivity of fructose. [scopus_id] => 57213185898;56539669500;57192653491;57208171446;8393778700;35195439800;56377266700; [from_id] => 76,73 [cauthor_ad] => [Sun, XY; Cui, HY]Shandong Univ Technol, Sch Chem & Chem Engn, Zibo 255000, Peoples R China. [hx_id] => 2378,2371 [datebase] => Scopus [sys_level_num] => 15_6 [sys_jg_type] => 11 [format_issn_issue_page_pub_year] => 775a85e2466f996b376b7a8931ac2d23-304399577 [title_en] => Isomerization Kinetics of Glucose to Fructose in Aqueous Solution with Magnesium-Aluminum Hydrotalcites [volume] => 5 [source_type] => 351 [pub_year] => 2020 [keyword_en] => fructose; glucose; isomerization; kinetics; Mg-Al hydrotalcites [article_id] => 813069,814475 [begin_page] => 270 [hints] => 8 [publisher] => WILEY-V C H VERLAG GMBH [doi] => 10.1002/slct.201903959 [language] => English [issue] => 1 [issn] => 2365-6549 [batch] => 3422,3424 [publication_en] => CHEMISTRYSELECT [email] => sunxiuyu@sdut.edu.cn; cuihy@sdut.edu.cn [sys_update_time] => 2020-03-13 09:56:31 [format_title_en_issn_pub_year] => 34769bf0c832f19b2faefcb2b13ae5d5-1668207036 [publication_iso] => ChemistrySelect [SYS_TAG] => 3 [end_page] => 279 [page] => 270-279 [hb_type] => 2 [article_dt] => Article [hb_batch] => grant_no [cite_wos] => 0 [check_3Y] => 1 [delivery_No] => KB3ZU [format_title] => [author_fn] => Li, Chunxiao; Wang, Yong; Zhang, Yuan; Wang, Ming; Sun, Xiuyu; Cui, Hongyou; Xie, Yujiao [pages] => 10 [publication_29] => CHEMISTRYSELECT [open_type] => Bronze [orcID] => Cui, Hongyou/0000-0003-4577-3835 [publication_type] => J [get_data] => 2020-03-06 [format_publication_cn] => [keyword_plu] => SOLID BASE CATALYSTS; MG-AL HYDROTALCITES; HETEROGENEOUS CATALYST; LEVULINIC ACID; CONVERSION; CONDENSATION; DEGRADATION; REACTIVITY; ISOMERASE; BASICITY [fund_ab] => The project was supported by the National Natural Science Foundations of; China (21978158 and 21476132), the Public Welfare Category of Key R&D; Programs in Shandong Province (2018GGX107003) and the Natural Science; Foundation of Shandong Province (ZR2018BB062). [format_title_en] => 5989b7efc00babdac04033de5777a1e1-721710148 [publisher_city] => WEINHEIM [pub_date] => JAN 9 [cauthor_order] => 5,6 [reference_No] => 48 [cite_awos] => 0 [wos_No] => WOS:000506438700035 [sys_priority_field] => 73 [format_wos_No] => 6dc1b0c82d458574150f25adbc3adda7-2142969944 [wos_sub] => Chemistry, Multidisciplinary [research_area] => Chemistry [cauthor_back] => Sun, XY@@@Cui, HY [check_180] => 1 [publisher_ad] => POSTFACH 101161, 69451 WEINHEIM, GERMANY [format_publication_en] => fad3620dbf54941f092c5fbf63ab844b1747514688 [jl_language] => english [jl_article_dt] => 期刊论文 [jl_publication_en] => chemistryselect [jl_country] => 中国 [jl_keyword_en] => isomerization,glucose,kinetics,mgalhydrotalcites,fructose [sys_author_in_last_arr] => peoplesrchina [jl_publisher] => wileyvchverlaggmbh [company_id] => 0,0 [author_id] => [id] => uwA103ABe-eYmRwwIxmf [tags] => 0 ) [18] => Array ( [cite_scopus] => 1 [cauthor] => Wang, W(wqingw61@163.com) [school_id] => 117 [scopus_No] => 2-s2.0-85077999442 [batch2] => 15 [uri] => https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077999442&doi=10.1016%2fS2213-8587%2819%2930425-5&partnerID=40&md5=e5dbe91c1610bb2601ccb8f7b71a311c [tag] => 0 [author_en] => Wang, TG; Lu, JL; Shi, LX; Chen, G; Xu, M; Xu, Y; Su, Q; Mu, YM; Chen, LL; Hu, RY; Tang, XL; Yu, XF; Li, M; Zhao, ZY; Chen, YH; Yan, L; Qin, GJ; Wan, Q; Dai, M; Zhang, D; Gao, ZN; Wang, GX; Shen, FX; Luo, ZJ; Qin, YF; Chen, L; Huo, YA; Li, Q; Ye, Z; Zhang, YF; Liu, C; Wang, YM; Wu, SL; Yang, T; Deng, HC; Zhao, JJ; Lai, SH; Bi, YF; DeFronzo, RA; Wang, WQ; Ning, G [publication_en] => LANCET DIABETES & ENDOCRINOLOGY [format_scopus_No] => a270deab9f9538f3dac4ca81569c2d11-729358956 [format_doi] => 304312aa556aa64bb0ed50d77737ee59-979670604 [author_in] => [Wang, Tiange; Lu, Jieli; Xu, Min; Xu, Yu; Li, Mian; Zhao, Zhiyun; Chen, Yuhong; Dai, Meng; Zhang, Di; Bi, Yufang; Wang, Weiqing; Ning, Guang] Shanghai Jiao Tong Univ, Shanghai Natl Clin Res Ctr Endocrine & Metab Dis, Ruijin Hosp,Natl Hlth Commiss PR China, Sch Med,Shanghai Inst Endocrine & Metab Dis, Shanghai, Peoples R China.@@@ [Shi, Lixin] Guiyang Med Coll, Affiliated Hosp, Guiyang, Peoples R China.@@@ [Chen, Gang] Fujian Med Univ, Fujian Prov Hosp, Fuzhou, Peoples R China.@@@ [Su, Qing] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Shanghai, Peoples R China.@@@ [Mu, Yiming] Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China.@@@ [Chen, Lulu] Huazhong Univ Sci & Technol, Union Hosp, Wuhan, Peoples R China.@@@ [Hu, Ruying; Ye, Zhen] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China.@@@ [Tang, Xulei] Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China.@@@ [Yu, Xuefeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China.@@@ [Yan, Li] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China.@@@ [Qin, Guijun] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China.@@@ [Wan, Qin] Southwest Med Univ, Affiliated Hosp, Luzhou, Peoples R China.@@@ [Gao, Zhengnan] Dalian Municipal Cent Hosp, Dalian, Peoples R China.@@@ [Wang, Guixia] First Hosp Jilin Univ, Changchun, Peoples R China.@@@ [Shen, Feixia] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China.@@@ [Luo, Zuojie; Qin, Yingfen] Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China.@@@ [Chen, Li] Shandong Univ, Qilu Hosp, Jinan, Peoples R China.@@@ [Huo, Yanan] Nanchang Univ, Jiangxi Prov Peoples Hosp, Nanchang, Jiangxi, Peoples R China.@@@ [Li, Qiang] Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China.@@@ [Zhang, Yinfei] Cent Hosp Shanghai Jiading Dist, Shanghai, Peoples R China.@@@ [Liu, Chao] Jiangsu Prov Hosp Integrat Chinese & Western Med, Nanjing, Peoples R China.@@@ [Wang, Youmin] Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China.@@@ [Wu, Shengli] Karamay Municipal Peoples Hosp, Xinjiang, Peoples R China.@@@ [Yang, Tao] Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China.@@@ [Deng, Huacong] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China.@@@ [Zhao, Jiajun] Shandong First Med Univ, Shandong Prov Hosp, Jinan, Peoples R China.@@@ [Lai, Shenghan] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.@@@ [DeFronzo, Ralph A.] UT Hlth San Antonio, Diabet Div, San Antonio, TX USA. [fund_No] => National Natural Science Foundation of ChinaNational Natural Science; Foundation of China [reference] => Zhou, B., Lu, Y., Hajifathalian, K., Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants (2016) Lancet, 387, pp. 1513-1530; IDF Diabetes Atlas, 8th edition http://www.diabetesatlas.org/, (Accessed 11 June 2019); Rothman, D.L., Magnusson, I., Cline, G., Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus (1995) Proc Natl Acad Sci USA, 92, pp. 983-987; Porte, D., Jr, Kahn, S.E., β-cell dysfunction and failure in type 2 diabetes: potential mechanisms (2001) Diabetes, 50, pp. S160-S163; Kodama, K., Tojjar, D., Yamada, S., Toda, K., Patel, C.J., Butte, A.J., Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis (2013) Diabetes Care, 36, pp. 1789-1796; Torréns, J.I., Skurnick, J., Davidow, A.L., Ethnic differences in insulin sensitivity and beta-cell function in premenopausal or early perimenopausal women without diabetes: the Study of Women\'s Health Across the Nation (SWAN) (2004) Diabetes Care, 27, pp. 354-361; Møller, J.B., Pedersen, M., Tanaka, H., Body composition is the main determinant for the difference in type 2 diabetes pathophysiology between Japanese and Caucasians (2014) Diabetes Care, 37, pp. 796-804; Ahuja, V., Kadowaki, T., Evans, R.W., Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study (2015) Diabetologia, 58, pp. 265-271; Møller, J.B., Dalla Man, C., Overgaard, R.V., Ethnic differences in insulin sensitivity, β-cell function, and hepatic extraction between Japanese and Caucasians: a minimal model analysis (2014) J Clin Endocrinol Metab, 99, pp. 4273-4280; Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants (2016) Lancet, 387, pp. 1377-1396; He, Y., Li, Y., Yang, X., The dietary transition and its association with cardiometabolic mortality among Chinese adults, 1982–2012: a cross-sectional population-based study (2019) Lancet Diabetes Endocrinol, 7, pp. 540-548; Kahn, S.E., Hull, R.L., Utzschneider, K.M., Mechanisms linking obesity to insulin resistance and type 2 diabetes (2006) Nature, 444, pp. 840-846; Lu, J., He, J., Li, M., Predictive value of fasting glucose, postload glucose, and hemoglobin A1c on risk of diabetes and complications in Chinese adults (2019) Diabetes Care, 42, pp. 1539-1548; Wang, T., Lu, J., Su, Q., Ideal cardiovascular health metrics and major cardiovascular events in patients with prediabetes and diabetes (2019) JAMA Cardiol, 4, pp. 874-883; Craig, C.L., Marshall, A.L., Sjöström, M., International physical activity questionnaire: 12-country reliability and validity (2003) Med Sci Sports Exerc, 35, pp. 1381-1395; Ainsworth, B.E., Haskell, W.L., Leon, A.S., Compendium of physical activities: classification of energy costs of human physical activities (1993) Med Sci Sports Exerc, 25, pp. 71-80; Xu, Y., Wang, L., He, J., Prevalence and control of diabetes in Chinese adults (2013) JAMA, 310, pp. 948-959; Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., Turner, R.C., Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man (1985) Diabetologia, 28, pp. 412-419; Diagnosis and classification of diabetes mellitus (2010) Diabetes Care, 33, pp. S62-S69; Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies (2004) Lancet, 363, pp. 157-163; Hsu, W.C., Araneta, M.R., Kanaya, A.M., Chiang, J.L., Fujimoto, W., BMI cut points to identify at-risk Asian Americans for type 2 diabetes screening (2015) Diabetes Care, 38, pp. 150-158; 2. Classification and Diagnosis of Diabetes: Standards of medical care in diabetes-2019 (2019) Diabetes Care, 42, pp. S13-S28; Wacholder, S., Benichou, J., Heineman, E.F., Hartge, P., Hoover, R.N., Attributable risk: advantages of a broad definition of exposure (1994) Am J Epidemiol, 140, pp. 303-309; Spiegelman, D., Hertzmark, E., Wand, H.C., Point and interval estimates of partial population attributable risks in cohort studies: examples and software (2007) Cancer Causes Control, 18, pp. 571-579; Hertzmark, E., Wand, H., Spiegelman, D., The SAS PAR Macro (2012), https://www.hsph.harvard.edu/donna-spiegelman/software/par/, (Accessed 30 September 2019); Chen, C., Lu, F.C., The guidelines for prevention and control of overweight and obesity in Chinese adults (2004) Biomed Environ Sci, 17, pp. 1-36; Wang, L., Gao, P., Zhang, M., Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013 (2017) JAMA, 317, pp. 2515-2523; Katsuki, A., Sumida, Y., Gabazza, E.C., Homeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes (2001) Diabetes Care, 24, pp. 362-365; Bonora, E., Targher, G., Alberiche, M., Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity (2000) Diabetes Care, 23, pp. 57-63; Stumvoll, M., Mitrakou, A., Pimenta, W., Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity (2000) Diabetes Care, 23, pp. 295-301; Haffner, S.M., Miettinen, H., Stern, M.P., The homeostasis model in the San Antonio Heart Study (1997) Diabetes Care, 20, pp. 1087-1092; Wallace, T.M., Levy, J.C., Matthews, D.R., Use and abuse of HOMA modeling (2004) Diabetes Care, 27, pp. 1487-1495 [format_title_en_publication_en_pub_year] => 95d75e790881b218b31f8a55dc23dea2-140392675 [abstract_en] => Background National investigations on the interaction of insulin resistance, beta-cell dysfunction, and obesity with the development of diabetes are scarce in China. We aimed to investigate the individual and joint associations of insulin resistance and beta-cell dysfunction with incident diabetes, and to examine the modifying effect of BMI and waist circumference on these associations among adults with normal glucose tolerance and with prediabetes.; Methods In this nationwide, population-based, prospective cohort study, we analysed data from the China Cardiometabolic Disease and Cancer Cohort Study, which recruited adults aged 40 years or older during 2011-12 (baseline) and invited participants to attend follow-up visits in 2014-16. Patients with diabetes at baseline, missing data for baseline measures of glucose tolerance status, missing data for baseline homoeostasis model assessment (HOMA) indexes, missing data for baseline covariates, and missing data for measures of glucose tolerance status at follow-up visits were excluded. At baseline and follow-up visits, a comprehensive set of questionnaires, dinical measurements, oral glucose tolerance tests, and laboratory examinations were carried out following standardised protocols. Glucose tolerance status and prediabetes were defined according to the American Diabetes Association 2010 criteria. In the main analysis, we examined the contributions of insulin resistance (HOMA of insulin resistance [HOMA-IR]) and beta-cell dysfunction (HOMA of beta-cell function [HOMA-B]) to diabetes risk, and evaluated the impact of obesity on these associations.; Findings 94952 participants (31517 men and 63 435 women) were included in the analysis. High HOMA-IR was associated with a greater hazard of diabetes (quartile 4 vs 1: hazard ratio [HR] 6.70, 95% CI 6.08-7.39; per unit increase in Z score: HR 2.17, 95% CI 2.10-2.24) than low HOMA-B (quartile 1 vs 4: 4.08, 3.72-4.48; per unit decrease in Z score: 1.92, 1.85-2.00). Approximately 24.4% (95% CI 23.6-25.2) of the incident diabetes could be attributed to insulin resistance and 12.4% (11.2-13.7) could be attributed to beta-cell dysfunction. The HRs for diabetes were 1.83 (95% CI 1.72-1.95) per unit increase in Z score of HOMA-IR and 2.03 (1.86-2.21) per unit decrease in Z score of HOMA-B among participants with normal weight; the corresponding H Rs for diabetes were 2.02 (1.93-2.11) and 1.88 (1.79-1.98) among participants with obesity (p(interaction) =0.0091). These associations and interactions were similar for participants with normal glucose tolerance or prediabetes.; Interpretation Insulin resistance shows a stronger association with incident diabetes than does beta-cell dysfunction in Chinese adults, and this association pattern was more prominent among adults with obesity. Given the limitations of HOMA indexes as surrogate measures of insulin resistance and beta-cell dysfunction, these findings should be interpreted with caution. Copyright (C) 2019 Published by Elsevier Ltd. All rights reserved. [scopus_id] => 36982431700;55550251800;7401640514;57022141800;36072190500;36982346300;36123923800;57203924520;57206671965;55649022700;55066730100;26665859900;57209946981;56171577500;57207352849;56004304300;57212540827;56520950100;8439239200;57060637100;35483614900;55992241000;55578391200;16069086500;14021952200;57022294500;56520934300;57200978004;56982261800;57207473762;57200271149;57207771971;55747001800;57201290802;7401775561;57206579649;57212013089;57213823706;57202842906;56927909200;57211831504; [from_id] => 76,73 [cauthor_ad] => [Wang, TG]Shanghai Jiao Tong Univ, Shanghai Natl Clin Res Ctr Endocrine & Metab Dis, Ruijin Hosp,Natl Hlth Commiss PR China, Sch Med,Shanghai Inst Endocrine & Metab Dis, Shanghai, Peoples R China. [hx_id] => 2378,2371 [datebase] => Scopus [sys_level_num] => 15_6 [sys_jg_type] => 11 [format_issn_issue_page_pub_year] => a11c1c17420b9a299daf78f76c8e81331072172938 [title_en] => Association of insulin resistance and beta-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study [index_keyword] => adult; Article; body mass; cardiovascular disease; China; clinical protocol; clinical study; cohort analysis; controlled study; data analysis; diabetes mellitus; disease association; female; follow up; glucose tolerance; hazard ratio; homeostasis model assessment; human; impaired glucose tolerance; incidence; insulin resistance; laboratory test; major clinical study; male; malignant neoplasm; metabolic disorder; obesity; oral glucose tolerance test; pancreas islet beta cell; pancreatic insufficiency; population research; priority journal; prospective study; questionnaire; waist circumference [standard_in] => Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Affiliated Hospital of Guiyang Medical College, Guiyang, China; Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China; Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Chinese People\'s Liberation Army General Hospital, Beijing, China; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China; The First Hospital of Lanzhou University, Lanzhou, China; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; The Affiliated Hospital of Southwest Medical University, Luzhou, China; Dalian Municipal Central Hospital, Dalian, China; The First Hospital of Jilin University, Changchun, China; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; The First Affiliated Hospital of Guangxi Medical University, Nanning, China; Qilu Hospital of Shandong University, Jinan, China; Jiangxi Provincial People\'s Hospital Affiliated to Nanchang University, Nanchang, China; The Second Affiliated Hospital of Harbin Medical University, Harbin, China; Central Hospital of Shanghai Jiading District, Shanghai, China; Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China; The First Affiliated Hospital of Anhui Medical University, Hefei, China; Karamay Municipal People\'s Hospital, Xinjiang, China; The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Shandong Provincial Hospital, Shandong First Medical University, Jinan, China; Johns Hopkins University School of Medicine, Baltimore, MD, United States; Diabetes Division, UT Health San Antonio, San Antonio, TX, United States [volume] => 8 [source_type] => 351 [pub_year] => 2020 [article_id] => 813657,819669 [begin_page] => 115 [hints] => 8 [publisher] => ELSEVIER SCIENCE INC [doi] => 10.1016/S2213-8587(19)30425-5 [language] => English [issue] => 2 [issn] => 2213-8587 [batch] => 3422,3424 [pubmedID] => 31879247 [email] => wqingw61@163.com [sys_update_time] => 2020-03-13 09:56:09 [format_title_en_issn_pub_year] => 972eb47c59471613544c745ff7dea2501049678443 [publication_iso] => Lancet Diabetes Endocrinol. [SYS_TAG] => 3 [end_page] => 124 [page] => 115-124 [hb_type] => 2 [article_dt] => Article [hb_batch] => grant_no [cite_wos] => 0 [check_3Y] => 3 [delivery_No] => KE1YG [format_title] => [author_fn] => Wang, Tiange; Lu, Jieli; Shi, Lixin; Chen, Gang; Xu, Min; Xu, Yu; Su, Qing; Mu, Yiming; Chen, Lulu; Hu, Ruying; Tang, Xulei; Yu, Xuefeng; Li, Mian; Zhao, Zhiyun; Chen, Yuhong; Yan, Li; Qin, Guijun; Wan, Qin; Dai, Meng; Zhang, Di; Gao, Zhengnan; Wang, Guixia; Shen, Feixia; Luo, Zuojie; Qin, Yingfen; Chen, Li; Huo, Yanan; Li, Qiang; Ye, Zhen; Zhang, Yinfei; Liu, Chao; Wang, Youmin; Wu, Shengli; Yang, Tao; Deng, Huacong; Zhao, Jiajun; Lai, Shenghan; Bi, Yufang; DeFronzo, Ralph A.; Wang, Weiqing; Ning, Guang [pages] => 10 [publication_29] => LANCET DIABETES ENDO [publication_type] => J [author_gro] => China Cardiometab Dis Canc Cohort [get_data] => 2020-03-06 [format_publication_cn] => [keyword_plu] => HOMEOSTASIS MODEL ASSESSMENT; ETHNIC-DIFFERENCES; GLUCOSE-TOLERANCE; SENSITIVITY; JAPANESE; PREVALENCE; INDEX; RISK [fund_ab] => National Natural Science Foundation of China. [format_title_en] => 133b6202a1e40c186d3e0d1f388610f1-24086968 [publisher_city] => NEW YORK [pub_date] => FEB [cauthor_order] => 1 [reference_No] => 32 [cite_awos] => 0 [wos_No] => WOS:000508354900014 [sys_priority_field] => 73 [format_wos_No] => b1558c3040caefc437f3ca24b7d1c656-2078748091 [wos_sub] => Endocrinology & Metabolism [research_area] => Endocrinology & Metabolism [cauthor_back] => Wang, TG [check_180] => 3 [publisher_ad] => STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA [format_publication_en] => cdb8df48f326f0f48ff7e1cee30451451328156416 [jl_language] => english [jl_article_dt] => 期刊论文 [jl_publication_en] => lancetdiabetesandendocrinology [jl_country] => 中国 [sys_author_in_last_arr] => peoplesrchina [jl_publisher] => elsevierscienceinc [company_id] => 0 [author_id] => 20281,20280,20277 [author_test] => Array ( [0] => Array ( [sure] => 0 [irmagnum] => 0 [u_index] => 26 [name] => 陈立 [irtag] => 7 [t_index] => 0 [person_id] => 20277 ) [1] => Array ( [sure] => 0 [irmagnum] => 0 [u_index] => 26 [name] => 陈莉 [irtag] => 7 [t_index] => 0 [person_id] => 20281 ) [2] => Array ( [sure] => 0 [irmagnum] => 0 [u_index] => 26 [name] => 陈利 [irtag] => 7 [t_index] => 0 [person_id] => 20280 ) ) [id] => PAA003ABe-eYmRww6g7I [tags] => 0 ) [19] => Array ( [cauthor] => Wang, Yuelan(wyldgf@163.com) [issn] => 1942-0900 [school_id] => 117 [controlled_terms] => Biomarkers - Diagnosis - Fatty acids - Mass spectrometers - Mass spectrometry - Metabolism - Metabolites - Nitric oxide [batch2] => 15 [hb_batch] => 3418 [ei_No] => 20200808186496 [tag] => 0 [author_en] => Qian, G; Wang, YL [abstract_en] => Postoperative cognitive dysfunction (POCD) is a common postoperative complication observed in elderly patients. However, the diagnosis of POCD is not very satisfactory as no specific biomarkers have been classified. It is necessary to identify new diagnostic markers to better understand the pathogenesis of POCD. We performed liquid chromatography with a time-of-flight mass spectrometer- (LC/Q-TOF-MS-) based metabolomics study to investigate POCD. A total of 40 metabolites were differentially expressed between POCD and non-POCD patients. In this study, we investigated whether phosphatidylserine (PS) (17:2/0:0), with an area under the curve value of 0.966, was a potential sensitive and specific biomarker for the diagnosis and prognosis of POCD. Pathway analysis showed that fatty acid metabolism, lipid metabolism, and carnitine metabolism were significantly altered in POCD. Network analysis indicated that nitric oxide signaling, PI3K-AKT signaling, mTOR signaling, and mitochondrial dysfunction were related to the pathogenesis of POCD. This study showed that metabolic profiling was meaningful when studying the diagnosis and pathogenesis of POCD. [format_doi] => 87a45f4d84bcbfad179dde7521691ad6-1164623475 [sys_update_time] => 2020-03-13 09:40:17 [cauthor_back] => Wang, Yuelan@@@Wang, YL [format_title_en_publication_en_pub_year] => c02ae4e735298d3ff55bd9b5b7a7be6a1548972158 [classification_No] => 461.6 Medicine and Pharmacology - 801 Chemistry - 804.1 Organic Compounds - 804.2 Inorganic Compounds [document_No] => 8957541 [main_eword] => Liquid chromatography [from_id] => 76,74,73 [email] => qg1261@shtrhospital.com; wyldgf@163.com [cauthor_order] => 2,2 [datebase] => Scopus [sys_level_num] => 15_8 [sys_jg_type] => 11 [title_en] => Serum Metabolomics of Early Postoperative Cognitive Dysfunction in Elderly Patients Using Liquid Chromatography and Q-TOF Mass Spectrometry [volume] => 2020 [author_fn] => Qian, Gang; Wang, YueLan [pub_year] => 2020 [eissn] => 1942-0994 [article_id] => 813445,808297,819241 [hints] => 5 [pub_date] => JAN 28 [publisher] => HINDAWI LTD [doi] => 10.1155/2020/8957541 [language] => English [source_type] => 351 [reference_No] => 33 [batch] => 3422,3418,3424 [publication_en] => OXIDATIVE MEDICINE AND CELLULAR LONGEVITY [hx_id] => 2376,2378,2371 [author_in] => [Qian, Gang; Wang, YueLan] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Anesthesiol, Jinan 250014, Peoples R China.@@@ [Qian, Gang] Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Anesthesiol, Shanghai 200336, Peoples R China. [format_title_en_issn_pub_year] => 5bf02efc369d50993df5f41d0a49d353-1057261626 [format_ei_No] => c1aa2fa721d1450f0561e85d9651d17a-969770351 [uncontrolled_terms] => Area under the curves - Diagnosis and prognosis - Fatty acid metabolism - Mitochondrial dysfunction - Nitric oxide signaling - Postoperative complications - Time-of-flight mass spectrometers - ToF mass spectrometry [SYS_TAG] => 3 [hb_type] => 2 [article_dt] => Article [fund_No] => Health and Family Planning Commission of Changning District, Shanghai; [20154Y006] [index_keyword] => Biomarkers; Diagnosis; Fatty acids; Mass spectrometers; Mass spectrometry; Metabolism; Metabolites; Nitric oxide; Area under the curves; Diagnosis and prognosis; Fatty acid metabolism; Mitochondrial dysfunction; Nitric oxide signaling; Postoperative complications; Time-of-flight mass spectrometers; ToF mass spectrometry; Liquid chromatography [format_title] => [reference] => Inouye, S.K., Delirium in older persons (2006) The New England Journal of Medicine, 354 (23), pp. 2509-2511; Glumac, S., Kardum, G., Sodic, L., Supe-Domic, D., Karanovic, N., Effects of dexamethasone on early cognitive decline after cardiac surgery (2017) European Journal of Anaesthesiology, 34 (11), pp. 776-784; Papadopoulou, E., Davilas, E., Sotiriou, V., Cell-free DNA and RNA in plasma as a new molecular marker for prostate cancer (2004) Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 14 (9), pp. 439-445; Sørensen, K.D., Ørntoft, T.F., Discovery of prostate cancer biomarkers by microarray gene expression profiling (2010) Expert Review of Molecular Diagnostics, 10 (1), pp. 49-64; Scherzer, C.R., Eklund, A.C., Morse, L.J., Molecular markers of early Parkinson\'s disease based on gene expression in blood (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (3), pp. 955-960; Wang, X., Yu, J., Sreekumar, A., Autoantibody signatures in prostate cancer (2005) The New England Journal of Medicine, 353 (12), pp. 1224-1235; Deidda, M., Piras, C., Bassareo, P.P., Cadeddu Dessalvi, C., Mercuro, G., Metabolomics, a promising approach to translational research in cardiology (2015) IJC Metabolic & Endocrine, 9, pp. 31-38; Patti, G.J., Yanes, O., Siuzdak, G., Metabolomics: The apogee of the omics trilogy (2013) Nature Reviews Molecular Cell Biology, 13 (4), pp. 263-269; Glade, M.J., Smith, K., Phosphatidylserine and the human brain (2015) Nutrition, 31 (6), pp. 781-786; Wang, X., She, H., Mao, Z., Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3beta in neuronal apoptosis (2009) Journal of Biological Chemistry, 284 (47), pp. 32619-32626; Kim, H., Huang, B.X., Spector, A.A., Phosphatidylserine in the brain: Metabolism and function (2014) Progress in Lipid Research, 56 (56), pp. 1-18; Laws, K.R., Irvine, K., Gale, T.M., Sex differences in cognitive impairment in Alzheimer\'s disease (2016) World Journal of Psychiatry, 6 (1), pp. 54-65; Vance, J.E., Phosphatidylserine and phosphatidylethanolamine in mammalian cells: Two metabolically related aminophospholipids (2008) Journal of Lipid Research, 49 (7), pp. 1377-1387; Paoletti, L., Elena, C., Domizi, P., Banchio, C., Role of phosphatidylcholine during neuronal differentiation (2011) IUBMB Life, 63 (9), pp. 714-720; Brazil, D.P., Hemmings, B.A., Ten years of protein kinase B signalling: A hard Akt to follow (2001) Trends in Biochemical Sciences, 26 (11), pp. 657-664; Kim, H.Y., Bigelow, J., Kevala, J.H., Substrate preference in phosphatidylserine biosynthesis for docosahexaenoic acid containing species (2004) Biochemistry, 43 (4), pp. 1030-1036; Kimura, A.K., Kim, H.Y., Phosphatidylserine synthase 2: High efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid (2013) Journal of Lipid Research, 54 (1), pp. 214-222; Hamilton, J., Greiner, R., Salem, N., Jr., Kim, H.Y., N-3 fatty acid deficiency decreases phosphatidylserine accumulation selectively in neuronal tissues (2000) Lipids, 35 (8), pp. 863-869; Cao, D., Xue, R., Xu, J., Liu, Z., Effects of docosahexaenoic acid on the survival and neurite outgrowth of rat cortical neurons in primary cultures (2005) The Journal of Nutritional Biochemistry, 16 (9), pp. 538-546; Kawakita, E., Hashimoto, M., Shido, O., Docosahexaenoic acid promotes neurogenesis in vitro and in vivo (2006) Neuroscience, 139 (3), pp. 991-997; Rao, M.A., Hatcher, J.F., Altered lipid metabolism in brain injury and disorders (2008) Lipids in Health and Disease, 49, pp. 241-268. , P. 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Cell. Longev. [format_title_en] => 7bacaab2344e5ae3709c493c8c7af20d-1432437556 [sys_priority_field] => 73 [uri] => https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079397817&doi=10.1155%2f2020%2f8957541&partnerID=40&md5=93945d340398b4cb5bf648a79f09d995 [standard_in] => Department of Anesthesiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, China; Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200336, China [scopus_No] => 2-s2.0-85079397817 [format_publication_en] => 9aa64f302abf4dcdeda29b02779a97091974129172 [cite_wos] => 0 [check_3Y] => 0 [delivery_No] => KN1OH [cauthor_ad] => [Wang, YL]Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Anesthesiol, Jinan 250014, Peoples R China. [pages] => 11 [publication_29] => OXID MED CELL LONGEV [open_type] => DOAJ Gold [publication_type] => J [get_data] => 2020-03-06 [keyword_plu] => DOCOSAHEXAENOIC ACID; L-CARNITINE; GENE-EXPRESSION; FATTY-ACIDS; PHOSPHATIDYLSERINE; ACCUMULATION; IMPAIRMENT; DECLINE; IMPACT [fund_ab] => This work was supported by grants from the Health and Family Planning; Commission of Changning District, Shanghai (No. 20154Y006). [publisher_city] => LONDON [cite_awos] => 0 [wos_No] => WOS:000514608400001 [format_wos_No] => a5f42d67f4f0b7f33885410e4c52d2ae1334975044 [wos_sub] => Cell Biology [research_area] => Cell Biology [check_180] => 0 [publisher_ad] => ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND [jl_language] => english [jl_article_dt] => 期刊论文 [jl_publication_en] => oxidativemedicineandcellularlongevity [jl_country] => 中国 [sys_author_in_last_arr] => peoplesrchina [jl_publisher] => hindawiltd [company_id] => 0 [author_id] => [id] => JAA403ABe-eYmRwwBCja [tags] => 0 ) ) 1-->
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5. CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway SCOPUS SCIE

作者:Zuo, Anju; Zhao, Xiaoyu; Li, Tingting; Li, Jun; Lei, Shengyun; Chen, Jiying; Xu, Dan; Song, Chengxiang; Liu, Tianjiao; Li, Cuigang; Guo, Yuan

作者机构:[Zuo, Anju; Li, Tingting; Lei, Shengyun; Chen, Jiying; Xu, Dan; Li, Cuigang; Guo, Yuan] Shandong Univ, Qilu Hosp, Dept Gen Med, Jinan, Peoples R China.; [Zuo, Anju; Zhao, Xiaoyu; Li, Tingting; Li, Jun; Lei, Shengyun; Chen, Jiying; Xu, Dan; Song, Chengxiang; Liu, Tianjiao; Li, Cuigang; Guo, Yuan] Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan, Peoples R China.; [Zuo, Anju; Zhao, Xiaoyu; Li, Tingting; Li, Jun; Lei, Shengyun; Chen, Jiying; Xu, Dan; Song, Chengxiang; Liu, Tianjiao; Li, Cuigang; Guo, Yuan] Shandong Univ, Qilu Hosp, Chinese Minist Hlth, Jinan, Peoples R China.; [Zhao, Xiaoyu] Shandong Univ, Jinan Cent Hosp, Res Ctr, Dept Clin Trial, Jinan, Peoples R China.; [Li, Tingting; Li, Jun; Chen, Jiying; Xu, Dan; Song, Chengxiang; Guo, Yuan] Shandong Univ, Qilu Hosp, Dept Cardiol, Jinan, Peoples R China.

来源:JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2020,Vol.24,Issue.4,2635-2647

资源类型:期刊论文

WOS:000506655900001

6. Carbon disulfide induced decidualization disorder in the mice uterus at the window of implantation SCOPUS SCIE

作者:Huang, Fengyan; Wu, Yanling; Zhang, Danhua; Liu, Xinai; Wang, Zhiping

作者机构:[Huang, Fengyan; Wu, Yanling; Zhang, Danhua; Liu, Xinai; Wang, Zhiping] Shandong Univ, Sch Publ Hlth, 44 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.; [Zhang, Danhua] Zhengzhou Eighth Peoples Hosp, Zhengzhou, Peoples R China.

来源:ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2020,Vol.190

资源类型:期刊论文

WOS:000509438100037

7. Application of support vector regression cooperated with modified artificial fish swarm algorithm for wind tunnel performance prediction of automotive radiators EI SCOPUS SCIE

作者:Yan, Wei; Li, Meijing; Pan, Xin; Wu, Guorong; Liu, Liping

作者机构:[Yan, Wei; Li, Meijing; Pan, Xin; Liu, Liping] Shandong Univ, Sch Energy & Power Engn, Jinan 250061, Shandong, Peoples R China.; [Wu, Guorong] Weifang Hengan Radiator Grp Co Ltd, Weifang 262100, Peoples R China.

来源:APPLIED THERMAL ENGINEERING,2020,Vol.164

资源类型:期刊论文

WOS:000498754900087

8. Noble metal-like behavior of plasmonic Bi particles deposited on reduced TiO2 microspheres for efficient full solar spectrum photocatalytic oxygen evolution EI SCOPUS SCIE

作者:Zhao, Hang; Liang, Zhangqian; Liu, Xiang; Qiu, Pengyuan; Cui, Hongzhi; Tian, Jian

作者机构:[Zhao, Hang; Liang, Zhangqian; Liu, Xiang; Qiu, Pengyuan; Cui, Hongzhi; Tian, Jian] Shandong Univ Sci & Technol, Sch Mat Sci & Engn, Qingdao 266590, Shandong, Peoples R China.

来源:CHINESE JOURNAL OF CATALYSIS,2020,Vol.41,Issue.2,333-340

资源类型:期刊论文

WOS:000499767400012

9. A fast Galerkin finite element method for a space-time fractional Allen-Cahn equation SCOPUS SCIE

作者:Liu, Huan; Cheng, Aijie; Wang, Hong

作者机构:[Liu, Huan; Cheng, Aijie] Shandong Univ, Sch Math, Jinan 250100, Shandong, Peoples R China.; [Wang, Hong] Univ South Carolina, Dept Math, Columbia, SC 29208 USA.

来源:JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS,2020,Vol.368

资源类型:期刊论文

WOS:000504504900018

10. Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in China SCOPUS SCIE

作者:Cong, Wei; Zhang, Nian-Zhang; Hu, Rui-Si; Zou, Feng-Cai; Zou, Yang; Zhong, Wen-Yan; Wu, Jing-Jing; Fallaize, Christopher J.; Zhu, Xing-Quan; Elsheikha, Hany M.

作者机构:[Cong, Wei] Shandong Univ, Marine Coll, Weihai 264209, Shandong, Peoples R China.; [Zhang, Nian-Zhang; Hu, Rui-Si; Zou, Yang; Zhu, Xing-Quan] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Key Lab Vet Parasitol Gansu Prov, Lanzhou, Gansu, Peoples R China.; [Zou, Feng-Cai] Yunnan Agr Univ, Coll Vet Med, Kunming 650201, Yunnan, Peoples R China.; [Zhong, Wen-Yan; Wu, Jing-Jing] Univ Calgary, Dept Math & Stat, Calgary, AB, Canada.; [Fallaize, Christopher J.] Univ Nottingham, Sch Math Sci, Nottingham, England.; [Fallaize, Christopher J.; Elsheikha, Hany M.] Univ Nottingham, Sch Vet Med & Sci, Fac Med & Hlth Sci, Sutton Bonington Campus, Loughborough, Leics, England.

来源:ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2020,Vol.189

资源类型:期刊论文

WOS:000507711500050

11. A New Fusion Algorithm for Depth Images Based on Virtual Views EI SCOPUS SCIE

作者:Liu, Jianchen; Zhang, Linjing; Wang, Zhen; Wang, Renli

作者机构:[Liu, Jianchen; Zhang, Linjing; Wang, Zhen; Wang, Renli] Shandong Univ Sci & Technol, Coll Geomat, Qingdao 266590, Peoples R China.

来源:IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING,2020,Vol.58,Issue.2,1171-1181

资源类型:期刊论文

WOS:000510710600033

12. Pyrethroid Insecticide Effect on Platelet Biomembranes of Rats SCOPUS SCIE

作者:Li, Qiuhuan; Liu, Xiaoyu; Maddu, Narendra; Zhao, Chuanli

作者机构:[Li, Qiuhuan; Zhao, Chuanli] Shandong Univ, Qilu Hosp, Dept Hematol, Jinan 250012, Shandong, Peoples R China.; [Liu, Xiaoyu] Jilin Univ, Sch Publ Hlth, Changchun 130012, Jilin, Peoples R China.; [Maddu, Narendra] Sri Krishnadevaraya Univ, Dept Biochem, Ananthapuramu 515003, Andhra Pradesh, India.

来源:POLISH JOURNAL OF ENVIRONMENTAL STUDIES,2020,Vol.29,Issue.1,703-711

资源类型:期刊论文

WOS:000501486900020

13. Androgen Receptor (AR)-TLR4 Crosstalk Mediates Gender Disparities in Hepatocellular Carcinoma Incidence and Progression SCOPUS SCIE

作者:Han, Qiuju; Yang, Dan; Yin, Chunlai; Zhang, Jian

作者机构:[Han, Qiuju; Yang, Dan; Yin, Chunlai; Zhang, Jian] Shandong Univ, Sch Pharmaceut Sci, Inst Immunopharmaceut Sci, Jinan 250012, Shandong, Peoples R China.

来源:JOURNAL OF CANCER,2020,Vol.11,Issue.5,1094-1103

资源类型:期刊论文

WOS:000502829400011

14. Low dimensional strongly perfect lattices IV: The dual strongly perfect lattices of dimension 16 SCOPUS SCIE

作者:Hu, Sihuang; Nebe, Gabriele

作者机构:[Hu, Sihuang] Shandong Univ, Minist Educ, Key Lab Cryptol Technol & Informat Secur, Jinan, Shandong, Peoples R China.; [Hu, Sihuang] Shandong Univ, Sch Cyber Sci & Technol, Jinan, Shandong, Peoples R China.; [Nebe, Gabriele] Rhein Westfal TH Aachen, Lehrstuhl Math, Aachen, Germany.

来源:JOURNAL OF NUMBER THEORY,2020,Vol.208,262-294

资源类型:期刊论文

WOS:000499759700012

15. aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model SCOPUS SCIE

作者:Chen, Jinmiao; Ma, Qing; King, Justin S.; Sun, Yan; Xu, Bing; Zhang, Xiaoyu; Zohrabian, Sylvia; Guo, Haipeng; Cai, Wenqing; Li, Gavin; Bruno, Ivone; Cooke, John P.; Wang, Chunsheng; Kontaridis, Maria; Wang, Da-Zhi; Luo, Hongbo; Pu, William T.; Lin, Zhiqiang

作者机构:[Chen, Jinmiao; Ma, Qing; King, Justin S.; Zhang, Xiaoyu; Zohrabian, Sylvia; Guo, Haipeng; Cai, Wenqing; Li, Gavin; Wang, Da-Zhi; Luo, Hongbo; Pu, William T.; Lin, Zhiqiang] Boston Childrens Hosp, Boston, MA 02115 USA.; [Chen, Jinmiao; Wang, Chunsheng] Fudan Univ, Zhongshan Hosp, Dept Cardiovasc Surg, Shanghai, Peoples R China.; [Chen, Jinmiao; Wang, Chunsheng] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai, Peoples R China.; [Sun, Yan; Xu, Bing; Kontaridis, Maria; Lin, Zhiqiang] Masonic Med Res Inst, Utica, NY 13501 USA.; [Guo, Haipeng] Shandong Univ, Dept Crit Care Med, Key Lab Cardiovasc Remodeling & Funct Res, Qilu Hosp,Chinese Minist Educ, Jinan, Peoples R China.; [Guo, Haipeng] Shandong Univ, Chinese Minist Hlth, Qilu Hosp, Jinan, Peoples R China.; [Cai, Wenqing] Dana Farber Canc Inst, Boston, MA 02115 USA.; [Bruno, Ivone; Cooke, John P.] Houston Methodist Res Inst, Houston, TX USA.; [Pu, William T.] Harvard Stem Cell Inst, Cambridge, MA 02138 USA.

来源:LIFE SCIENCE ALLIANCE,2020,Vol.3,Issue.1

资源类型:期刊论文

WOS:000511446200007

16. Enterotype Bacteroides Is Associated with a High Risk in Patients with Diabetes: A Pilot Study SCOPUS SCIE

作者:Wang, Jiajia; Li, Wenjuan; Wang, Chuan; Wang, Lingshu; He, Tianyi; Hu, Huiqing; Song, Jia; Cui, Chen; Qiao, Jingting; Qing, Li; Li, Lili; Zang, Nan; Wang, Kewei; Wu, Chuanlong; Qi, Lin; Ma, Aixia; Zheng, Huizhen; Hou, Xinguo; Liu, Fuqiang; Chen, Li

作者机构:[Wang, Jiajia; Li, Wenjuan; Wang, Chuan; Wang, Lingshu; He, Tianyi; Hu, Huiqing; Song, Jia; Cui, Chen; Qiao, Jingting; Qing, Li; Li, Lili; Zang, Nan; Wang, Kewei; Wu, Chuanlong; Qi, Lin; Ma, Aixia; Zheng, Huizhen; Hou, Xinguo; Liu, Fuqiang; Chen, Li] Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250012, Shandong, Peoples R China.; [Wang, Jiajia; Li, Wenjuan; Wang, Chuan; Wang, Lingshu; He, Tianyi; Hu, Huiqing; Song, Jia; Cui, Chen; Qiao, Jingting; Qing, Li; Li, Lili; Zang, Nan; Wang, Kewei; Wu, Chuanlong; Qi, Lin; Ma, Aixia; Zheng, Huizhen; Hou, Xinguo; Liu, Fuqiang; Chen, Li] Shandong Univ, Inst Endocrine & Metab Dis, Jinan 250012, Shandong, Peoples R China.; [Wang, Jiajia; Li, Wenjuan; Wang, Chuan; Wang, Lingshu; He, Tianyi; Hu, Huiqing; Song, Jia; Cui, Chen; Qiao, Jingting; Qing, Li; Li, Lili; Zang, Nan; Wang, Kewei; Wu, Chuanlong; Qi, Lin; Ma, Aixia; Zheng, Huizhen; Hou, Xinguo; Liu, Fuqiang; Chen, Li] Shandong Prov Med & Hlth, Key Lab Endocrine & Metab Dis, Jinan 250012, Shandong, Peoples R China.

来源:JOURNAL OF DIABETES RESEARCH,2020,Vol.2020

资源类型:期刊论文

WOS:000510872000003

17. Shikonin improve sepsis-induced lung injury via regulation of miRNA-140-5p/TLR4-a vitro and vivo study SCOPUS SCIE

作者:Zhang, Ying Ying; Liu, Xue; Zhang, Xiaojie; Zhang, Jingjing

作者机构:[Zhang, Ying Ying] Linyi Cent Hosp, Dept Hand & Foot Surg, Linyi, Shandong, Peoples R China.; [Liu, Xue] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Respirat, Jinan, Shandong, Peoples R China.; [Zhang, Xiaojie] Shandong Prov Chest Hosp, Surg Intens Care Unit, Jinan, Shandong, Peoples R China.; [Zhang, Jingjing] Shandong Prov Chest Hosp, Resp & Crit Med Ward 7, Jinan 250013, Shandong, Peoples R China.

来源:JOURNAL OF CELLULAR BIOCHEMISTRY,2020,Vol.121,Issue.3,2103-2117

资源类型:期刊论文

WOS:000498412800001

18. Isomerization Kinetics of Glucose to Fructose in Aqueous Solution with Magnesium-Aluminum Hydrotalcites SCOPUS SCIE

作者:Li, Chunxiao; Wang, Yong; Zhang, Yuan; Wang, Ming; Sun, Xiuyu; Cui, Hongyou; Xie, Yujiao

作者机构:[Li, Chunxiao; Wang, Yong; Zhang, Yuan; Wang, Ming; Sun, Xiuyu; Cui, Hongyou; Xie, Yujiao] Shandong Univ Technol, Sch Chem & Chem Engn, Zibo 255000, Peoples R China.

来源:CHEMISTRYSELECT,2020,Vol.5,Issue.1,270-279

资源类型:期刊论文

WOS:000506438700035

19. Association of insulin resistance and beta-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study SCOPUS SCIE

作者:Wang, Tiange; Lu, Jieli; Shi, Lixin; Chen, Gang; Xu, Min; Xu, Yu; Su, Qing; Mu, Yiming; Chen, Lulu; Hu, Ruying; Tang, Xulei; Yu, Xuefeng; Li, Mian; Zhao, Zhiyun; Chen, Yuhong; Yan, Li; Qin, Guijun; Wan, Qin; Dai, Meng; Zhang, Di; Gao, Zhengnan; Wang, Guixia; Shen, Feixia; Luo, Zuojie; Qin, Yingfen; Chen, Li; Huo, Yanan; Li, Qiang; Ye, Zhen; Zhang, Yinfei; Liu, Chao; Wang, Youmin; Wu, Shengli; Yang, Tao; Deng, Huacong; Zhao, Jiajun; Lai, Shenghan; Bi, Yufang; DeFronzo, Ralph A.; Wang, Weiqing; Ning, Guang

作者机构:[Wang, Tiange; Lu, Jieli; Xu, Min; Xu, Yu; Li, Mian; Zhao, Zhiyun; Chen, Yuhong; Dai, Meng; Zhang, Di; Bi, Yufang; Wang, Weiqing; Ning, Guang] Shanghai Jiao Tong Univ, Shanghai Natl Clin Res Ctr Endocrine & Metab Dis, Ruijin Hosp,Natl Hlth Commiss PR China, Sch Med,Shanghai Inst Endocrine & Metab Dis, Shanghai, Peoples R China.; [Shi, Lixin] Guiyang Med Coll, Affiliated Hosp, Guiyang, Peoples R China.; [Chen, Gang] Fujian Med Univ, Fujian Prov Hosp, Fuzhou, Peoples R China.; [Su, Qing] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Shanghai, Peoples R China.; [Mu, Yiming] Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China.; [Chen, Lulu] Huazhong Univ Sci & Technol, Union Hosp, Wuhan, Peoples R China.; [Hu, Ruying; Ye, Zhen] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China.; [Tang, Xulei] Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China.; [Yu, Xuefeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China.; [Yan, Li] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China.; [Qin, Guijun] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China.; [Wan, Qin] Southwest Med Univ, Affiliated Hosp, Luzhou, Peoples R China.; [Gao, Zhengnan] Dalian Municipal Cent Hosp, Dalian, Peoples R China.; [Wang, Guixia] First Hosp Jilin Univ, Changchun, Peoples R China.; [Shen, Feixia] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China.; [Luo, Zuojie; Qin, Yingfen] Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China.; [Chen, Li] Shandong Univ, Qilu Hosp, Jinan, Peoples R China.; [Huo, Yanan] Nanchang Univ, Jiangxi Prov Peoples Hosp, Nanchang, Jiangxi, Peoples R China.; [Li, Qiang] Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China.; [Zhang, Yinfei] Cent Hosp Shanghai Jiading Dist, Shanghai, Peoples R China.; [Liu, Chao] Jiangsu Prov Hosp Integrat Chinese & Western Med, Nanjing, Peoples R China.; [Wang, Youmin] Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China.; [Wu, Shengli] Karamay Municipal Peoples Hosp, Xinjiang, Peoples R China.; [Yang, Tao] Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China.; [Deng, Huacong] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China.; [Zhao, Jiajun] Shandong First Med Univ, Shandong Prov Hosp, Jinan, Peoples R China.; [Lai, Shenghan] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.; [DeFronzo, Ralph A.] UT Hlth San Antonio, Diabet Div, San Antonio, TX USA.

来源:LANCET DIABETES & ENDOCRINOLOGY,2020,Vol.8,Issue.2,115-124

资源类型:期刊论文

WOS:000508354900014

20. Serum Metabolomics of Early Postoperative Cognitive Dysfunction in Elderly Patients Using Liquid Chromatography and Q-TOF Mass Spectrometry EI SCOPUS SCIE

作者:Qian, Gang; Wang, YueLan

作者机构:[Qian, Gang; Wang, YueLan] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Anesthesiol, Jinan 250014, Peoples R China.; [Qian, Gang] Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Anesthesiol, Shanghai 200336, Peoples R China.

来源:OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2020,Vol.2020

资源类型:期刊论文

WOS:000514608400001

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