标题：Steam Processing Improves Negative Inotropic and Chronotropic Effects of Rehmannia Root on Isolated Toad and Rat Hearts
作者：Li, Li-Fen; Gao, Hui-Feng; Shi, Cheng-Jin; Wen, Xue-Sen
作者机构：[Li, Li-Fen; Gao, Hui-Feng; Shi, Cheng-Jin; Wen, Xue-Sen] Shandong Univ, Sch Pharmaceut Sci, Inst Pharmacognosy, Jinan 250012, Peoples R China.
会议名称：International Conference on Medicine and Biopharmaceuticals (ICMB)
会议日期：AUG 15-16, 2015
来源：PROCEEDINGS OF THE 2015 INTERNATIONAL CONFERENCE ON MEDICINE AND BIOPHARMACEUTICALS
摘要：Rehmannia root is a well-known herbal medicine used for more than 2000 years in China. According to the traditional experiences, the dried and steamed rehmannia roots (DRR and SRR) are significantly different in their functions and indications. However, the rationality of the steam processing has not been well documented up to now. In this work, the traditional methods of root drying and steaming were simulated, and the cardioactive effects of the samples steamed for different times (0-48 h) were evaluated on isolated toad and rat hearts. The results indicated that DRR had significantly negative inotropic and chronotropic activities, and the effects were substantially reinforced by steam processing. The products of Maillard reaction may be the primary active components targeting Ca2+ channel.