标题：Production and development of xanthan gum and its research progress in medical field
作者：Song Z.-G.; Ling P.-X.; Zhang T.-M.
作者机构：[Song, Z.-G] School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China, Post-doctoral Scientific Research Workstation, Institute of 更多
通讯作者地址：Ling, P.-X.; School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; 电子邮件: firstname.lastname@example.org
来源：Chinese Journal of Pharmaceutical Biotechnology
关键词：Application; Development; Medicine; Osteoarthritis; Polysaccharide; Production; Xanthan gum
摘要：Xanthan gum is an extracellular heteropolysaccharide produced from fermentation of Xanthomonas campestris. Xanthan gum has of many properties such as high stability, pseudoplastic rheology, thickening, emulsion and suspension stabilization, and safety. In medical field, xanthan gum is mainly used as pharmaceutic adjuvant. At present, the production process of purified xanthan gum for injection was established, which was suitable for industrial scale, and the quality standard was also established. Studies were carried out on xanthan gum intra-articular injection and its pharmacodynamics and action mechanism on experimental osteoarthritis (OA). The rabbit knee OA model was induced through intra-articular injection of papain and the protective effect of xanthan gum on articular cartilage was evaluated. The alleviative effect of xanthan gum on pain and cartilage degradation in a rat knee OA model induced by monosodium iodoacetate was evaluated. The results of xanhtan gum on rabbit OA showed that intra-articular injection significantly reduced the damage of cartilage surfaces, decresed the contents of interleukin-1β, tumor necrosis factor-α, NO and prostaglandin E2 in synovial fluid, inhibited chondrocytes apoptosis and matrix metalloproteinase-1, -3 levels in cartilage, enhanced glyco-saminoglycan and tissue inhibitor of metal protease-1 production in cartilage. Futhermore, no signficant differences between the xanthan treated group (intra-articular injection of xanthan gum once every two weeks for 5 weeks) and the sodium hyaluronate treated group (intra-articular injection of sodium hyaluronate once a week for 5 weeks) were observed. The results of xanhtan gum on rat OA showed that intra-articular injection significantly reduced OA pain and alleviated the joint cartilage degradation induced by mono-sodium iodoacetate. Xanthan gum also exhibited protective effect on rabbit chondrocytes in the presence of interleukin-1β. Intra-articular injection of xanthan gum was probably a new therapeutic method of OA. According to the properties of xanthan gum, it could also be used in other field. In this article, the production and development of xanthan gum and its research progress in medical field were reviewed.