标题:MicroRNA-1297 regulates hepatocellular carcinoma cell proliferation and apoptosis by targeting EZH2
作者:Liu, Fenghua; He, Yukai; Shu, Ronghua; Wang, Sikui
作者机构:[Liu, Fenghua; He, Yukai; Wang, Sikui] Liaocheng Peoples Hosp, Dept Infect Dis, Liaocheng 252000, Shandong, Peoples R China.; [Shu, Ronghua] Shandon 更多
通讯作者:Shu, RH
通讯作者地址:[Shu, RH]Shandong Univ, Jinan Cent Hosp, Dept Gastroenterol, 105 Jiefang Rd, Jinan 250000, Shandong, Peoples R China.
来源:INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
出版年:2015
卷:8
期:5
页码:4972-4980
关键词:miRNA; miR-1297; EZH2; hepatocellular carcinoma
摘要:In this study, we suggested the level of miR-1297 was downreguled in the human hepatocellular carcinoma compared to the normal cells. We demonstrate ectopic expression of miR-1297 could significantly suppress hepatocellular carcinoma cells proliferation and enhance the cell apoptosis. In vitro reporter assay suggested EZH2 is a direct target gene of miR-1297. Furthermore, knockdown of EZH2 have the same effect with miR-1297 over-eexpression in hepatocellular carcinoma cells. These findings provide evidence that miR-1297 plays a key role in inhibition of the hepatocellular carcinoma cells proliferation, and enhancing cell apoptosis through targeting EZH2, and strongly suggest that ex ogenous miR-1297 may have therapeutic value in treating hepatocellular carcinoma.
收录类别:SCOPUS;SCIE
WOS核心被引频次:18
Scopus被引频次:18
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937861384&partnerID=40&md5=fbef233ed9fc3bc19b16e33d64d3f59b
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