标题：Intravenous administration of gadolinium diethylene trianminepentaacetic acid affects diffusion-weighted imaging of focal liver lesions
作者：Guo, Weihua; Zhao, Suhong; Pang, Guodong; Li, Zhaohua; Shao, Guangrui
作者机构：[Guo, Weihua; Zhao, Suhong; Pang, Guodong; Li, Zhaohua; Shao, Guangrui] Shandong Univ, Hosp 2, Dept Radiol, 247 Beiyuan Rd, Jinan 250033, Shandong, Pe 更多
通讯作者地址：[Shao, GR]Shandong Univ, Hosp 2, Dept Radiol, 247 Beiyuan Rd, Jinan 250033, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
关键词：Focal liver lesions; magnetic resonance imaging; diffusion-weighted; imaging; apparent diffusion coefficient; gadolinium; diethylene-trianminepentaacetic acid
摘要：Objectives: The present study is to investigate whether intravenous administration of gadolinium-diethylene-trianminepentaacetic acid (Gd-DTPA) significantly affects diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values of focal liver lesions (FLLs). Methods: A total of 26 patients with 26 FLLs, including 6 hemangioma and 20 hepatocellular carcinoma, underwent DWI with b value of 600 s/mm(2) before and after intravenous administration of Gd-DTPA. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of FLLs were calculated on DWI. ADC values of FLLs were measured on ADC maps. The statistical significance of differences between precontrast and postcontrast data was determined using paired t-test. Results: On DWI, the SNR and CNR of FLLs on postcontrast DWI were significantly higher than those on precontrast DWI (P=0.036 and P=0.008, respectively). ADC values of the lesions were significantly lower on postcontrast DWI than on precontrast DWI (P=0.019). Conclusions: The SNR and CNR of FLLs on DWI were significantly increased after Gd-DTPA injection. However, ADC values of FLLs were significantly decreased after Gd-DTPA injection. If ADC measurements are taken into account, DWI should be performed before Gd-DTPA injection.