标题:A Systematic Review of Uric Acid Transporter 1(URAT1) Inhibitors for the Treatment of Hyperuricemia and Gout and an Insight into the Structure-activity Relationship(SAR)
作者:蔡文卿;刘巍;刘长鹰;王建武;赵桂龙;
作者机构:[蔡文卿;刘巍;刘长鹰;王建武;赵桂龙]School of Chemistry and Chemical Engineering, Shandong University;[蔡文卿;刘巍;刘长鹰;王建武;赵桂龙]Tianjin Key Labo 更多
来源:结构化学
出版年:2017
期:06
页码:897-910
关键词:gout;hyperuricemia;urate-lowering therapy;uricosuric;URAT1 inhibitor;structure-activity relationship(SAR)
摘要:Gout is caused by the deposition of uric acid as monosodium urate(MSU). Chronic hyperuricemia is the necessary condition for MSU deposition, which arises from over-production and/or under-excretion of uric acid. Renal under-excretion of uric acid accounts for greater than 90% of the patients with hy...
资源类型:期刊论文
原文链接:http://kns.cnki.net/kns/detail/detail.aspx?FileName=JGHX201706003&DbName=CJFQ2017
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