标题：Update on the Slow Delayed Rectifier Potassium Current (I-Ks): Role in Modulating Cardiac Function
作者：Liu, Zhenzhen; Du, Lupei; Li, Minyong
作者机构：[Liu, Zhenzhen; Du, Lupei; Li, Minyong] Shandong Univ, Dept Med Chem, Sch Pharm, Jinan 250012, Shandong, Peoples R China.
通讯作者地址：[Li, MY]Shandong Univ, Dept Med Chem, Sch Pharm, Jinan 250012, Shandong, Peoples R China.
来源：CURRENT MEDICINAL CHEMISTRY
关键词：The slow delayed rectifier potassium current; I-Ks; KCNQ1; KCNE1;; antiarrhythmic agents; cardiac arrhythmia; KvLQT1; Chromanol293B;; HMR1556; L-768; 673; I-Ks activator
摘要：The slow delayed rectifier current (I-Ks) is the slow component of cardiac delayed rectifier current and is critical for the late phase repolarization of cardiac action potential. This current is also an important target for Sympathetic Nervous System (SNS) to regulate the cardiac electivity to accommodate to heart rate alterations in response to exercise or emotional stress and can be up-regulated by beta-adrenergic or other signal molecules. I-Ks channel is originated by the co-assembly of pore-forming KCNQ1 alpha-subunit and accessory KCNE1 beta-subunit. Mutations in any subunit can bring about severe long QT syndrome (LQT-1, LQT-5) as characterized by deliquium, seizures and sudden death. This review summarizes the normal physiological functions and molecular basis of I-Ks channels, as well as illustrates up-to-date development on its blockers and activators. Therefore, the current extensive survey should generate fundamental understanding of the role of I-Ks channel in modulating cardiac function and donate some instructions to the progression of I-Ks blockers and activators as potential antiarrhythmic agents or pharmacological tools to determine the physiological and pathological function of I-Ks.