标题：Serum levels of Glial fibrillary acidic protein in Chinese children with autism spectrum disorders
作者：Wang, Jingwei; Zou, Qiuyan; Han, Renfeng; Li, Yupeng; Wang, Yulin
作者机构：[Wang, Jingwei; Wang, Yulin] Shandong Univ, Shandong Prov Hosp, Dept Pediat, 324 Jingwu Rd, Jinan 250021, Peoples R China.; [Wang, Jingwei; Han, Ren 更多
通讯作者地址：[Wang, YL]Shandong Univ, Shandong Prov Hosp, Dept Pediat, 324 Jingwu Rd, Jinan 250021, Peoples R China.
来源：INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
关键词：Autism spectrum disorders; Glial fibrillary acidic protein; Chinese
摘要：Objective: Glial fibrillary acidic protein (GFAP) has been studied in many neurological diseases. The purpose of this study is to investigate the potential role of GFAP in Chinese children with autism spectrum disorders (ASD) by measuring serum circulating levels of GFAP and comparing them with age and gender-matched typical development children.; Methods: A total of one hundred and fifty 2-6 years old Chinese children (75 confirmed autism cases and 75 their age-gender matched typical development children) participated in this study. Serum levels of GFAP were assayed with enzyme-linked immunosorbent assay methods, and severity of ASD was evaluated with the Childhood Autism Rating Scale (CARS) Score.; Results: The results indicated that the mean serum GFAP level was significantly (P < 0.001) higher in autistic children as compared to controls (1.71 +/- 0.53 ng/ml vs. 0.99 +/- 0.25 ng/ml). There was a significant positive association between serum GFAP levels and CARS scores (r [Pearson] = 0.390, P=0.001). Based on the Receiver operating characteristic (ROC) curve, the optimal cut-off value of serum GFAP levels as an indicator for auxiliary diagnosis of autism was projected to be 1.28 ng/ml which yielded a sensitivity of 77.3% and a specificity of 88.4%, the area under the curve was 0.895(95%Cl 0.844-0.947). Further, an increased risk of ASD was associated with GFAP levels >1.28 ng/ml (adjusted OR 9.88, 95% CI: 3.32-17.82) in the multivariate logistic analysis model.; Conclusion: The data indicates that serum GFAP levels may be associated with severity of ASD among Chinese children, suggesting the hypothesis that increased serum levels of GFAP could be implicated in the pathophjrsiology of autism in Chinese children. (C) 2017 ISDN. Published by Elsevier Ltd. All rights reserved.