标题：The mechanism of invariant natural killer T cells in regulating autoimmune diseases
作者：Zhao S.-Y.; Bi H.-S.
作者机构：[Zhao, S.-Y] Eye Institute of Shandong, Lab of Integrated Trad Chinese and Western Med for Prev and Ther of Ocular Dis in Univ of Shandong, Affiliated 更多
通讯作者地址：Bi, H.-S.; Eye Institute of Shandong, Lab of Integrated Trad Chinese and Western Med for Prev and Ther of Ocular Dis in Univ of Shandong, Affiliated E 更多
来源：Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology
关键词：Immune; Natural killer T cell; T-helper cell; Uveitis/experimental autoimmune
摘要：Studies demonstrated that natural killer T (NKT) cells are involved in the diverse immunomodulatory responses. But the mechanism that NKT cells regulate pathogenic T helper cells (Th) are still unclear. Recent researches found that Th17 cells are associated with a variety of autoimmune disease and play a crucial role in autoimmune diseases, which is very different from previous thesis that Th1 and Th2 are the key factors in the immune response in the patients with autoimmune disease. Studies both in vitro and in vivo also documented that invariant NKT cells (iNKT) inhibit the differentiation of CD4+ T cells toward Th1 and Th17 cells at the different mechanisms. The concept of NKT cells, the regulation of NKT cells to Th1 and Th17 cells in the autoimmune diseases were reviewed. Copyright © 2013 by the Chinese Medical Association.