标题：Roles of insulin-like growth factor II in regulating female reproductive physiology
作者：Muhammad, Tahir; Li, Mengjing; Wang, Jianfeng; Huang, Tao; Zhao, Shigang; Zhao, Han; Liu, Hongbin; Chen, Zi-Jiang
作者机构：[Muhammad, Tahir; Li, Mengjing; Wang, Jianfeng; Huang, Tao; Zhao, Shigang; Zhao, Han; Liu, Hongbin; Chen, Zi-Jiang] Shandong Univ, Cheeloo Coll Med, C 更多
通讯作者地址：Liu, HB; Chen, ZJ (corresponding author), Shandong Univ, Cheeloo Coll Med, Ctr Reprod Med, Jinan 250012, Peoples R China.; Liu, HB; Chen, ZJ (correspo 更多
来源：SCIENCE CHINA-LIFE SCIENCES
关键词：growth factors; IGF-II; oocyte maturation; embryonic development;; placentation; fetal growth
摘要：The number of growth factors involved in female fertility has been extensively studied, but reluctance to add essential growth factors in culture media has limited progress in optimizing embryonic growth and implantation outcomes, a situation that has ultimately led to reduced pregnancy outcomes. Insulin-like growth factor II (IGF-II) is the most intricately regulated of all known reproduction-related growth factors characterized to date, and is perhaps the predominant growth factor in human ovarian follicles. This review aims to concisely summarize what is known about the role of IGF-II in follicular development, oocyte maturation, embryonic development, implantation success, placentation, fetal growth, and in reducing placental cell apoptosis, as well as present strategies that use growth factors in culture systems to improve the developmental potential of oocytes and embryos in different species. Synthesizing the present knowledge about the physiological roles of IGF-II in follicular development, oocyte maturation, and early embryonic development should, on the one hand, deepen our overall understanding of the potential beneficial effects of growth factors in female reproduction and on the other hand support development (optimization) of improved outcomes for assisted reproductive technologies.