标题：mTOR Signaling in T Cell Immunity and Autoimmunity
作者：Liu, Yu; Zhang, Da-tong; Liu, Xin-guang
作者机构：[Liu, Yu; Zhang, Da-tong] Qilu Univ Technol, Sch Chem & Pharmaceut Engn, Jinan, Peoples R China.; [Liu, Yu; Liu, Xin-guang] Shandong Univ, Qilu Hosp 更多
通讯作者地址：[Liu, XG]Shandong Univ, Qilu Hosp, Dept Hematol, 107 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
来源：INTERNATIONAL REVIEWS OF IMMUNOLOGY
关键词：autoimmunity; mTOR; T cell immunity
摘要：The mammalian target of rapamycin (mTOR), a phosphoinositide-3-kinase-related protein kinase, acts as a rheostat capable of integrating a variety of environmental cues in the form of nutrients, energy, and growth factors to modulate organismal processes and homeostasis. Recently, there is a growing appreciation of mTOR in adaptive immunity for its crucial roles in keeping a proper balance between T cell quiescence and activation. Under steady-state circumstances, mTOR is subtly inhibited by multiple mechanisms to maintain normal T cell homeostasis. Antigen recognition by naive T cells leads to mTOR activation, which subsequently promotes the differentiation of these cells into distinct effector T cell subsets. This review focuses primarily on the recent literature with respect to the regulatory effects and mechanisms of mTOR signaling in dictating T cell fate, and discusses the therapeutic implications of mTOR modulation in T-cell-mediated autoimmunity.