标题:mTOR Signaling in T Cell Immunity and Autoimmunity
作者:Liu, Yu; Zhang, Da-tong; Liu, Xin-guang
作者机构:[Liu, Yu; Zhang, Da-tong] Qilu Univ Technol, Sch Chem & Pharmaceut Engn, Jinan, Peoples R China.; [Liu, Yu; Liu, Xin-guang] Shandong Univ, Qilu Hosp 更多
通讯作者:Liu, XG
通讯作者地址:[Liu, XG]Shandong Univ, Qilu Hosp, Dept Hematol, 107 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
来源:INTERNATIONAL REVIEWS OF IMMUNOLOGY
出版年:2015
卷:34
期:1
页码:50-66
DOI:10.3109/08830185.2014.933957
关键词:autoimmunity; mTOR; T cell immunity
摘要:The mammalian target of rapamycin (mTOR), a phosphoinositide-3-kinase-related protein kinase, acts as a rheostat capable of integrating a variety of environmental cues in the form of nutrients, energy, and growth factors to modulate organismal processes and homeostasis. Recently, there is a growing appreciation of mTOR in adaptive immunity for its crucial roles in keeping a proper balance between T cell quiescence and activation. Under steady-state circumstances, mTOR is subtly inhibited by multiple mechanisms to maintain normal T cell homeostasis. Antigen recognition by naive T cells leads to mTOR activation, which subsequently promotes the differentiation of these cells into distinct effector T cell subsets. This review focuses primarily on the recent literature with respect to the regulatory effects and mechanisms of mTOR signaling in dictating T cell fate, and discusses the therapeutic implications of mTOR modulation in T-cell-mediated autoimmunity.
收录类别:SCOPUS;SCIE
WOS核心被引频次:7
Scopus被引频次:11
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921281866&doi=10.3109%2f08830185.2014.933957&partnerID=40&md5=b5f24182031e896cfe944c888bb3a0b7
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