标题：Fluorine-18 labeled amino acids for tumor PET/CT imaging
作者：Qi, Yiqiang; Liu, Xiaohui; Li, Jun; Yao, Huiqian; Yuan, Shuanghu
作者机构：[Qi, Yiqiang; Liu, Xiaohui] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Jinan, Shandong, Peoples R China.; [Qi, Yiqiang; Liu, Xiaohui; Yu 更多
通讯作者：Yuan, SH;Yuan, SH;Yuan, SH
通讯作者地址：[Yuan, SH]Shandong Univ, Shandong Canc Hosp, Dept Radiat Oncol, Jinan, Shandong, Peoples R China;[Yuan, SH]Shandong Univ, Inst Shandong Canc Hosp, Jin 更多
关键词：Fluorine-18 labeled amino acids; positron emission tomography/computed; tomography (PET/CT); tumor metabolism; molecular imaging
摘要：Tumor glucose metabolism and amino acid metabolism are usually enhanced, F-18-FDG for tumor glucose metabolism PET imaging has been clinically well known, but tumor amino acid metabolism PET imaging is not clinically familiar. Radiolabeled amino acids (AAs) are an important class of PET/CT tracers that target the upregulated amino acid transporters to show elevated amino acid metabolism in tumor cells. Radiolabeled amino acids were observed to have high uptake in tumor cells but low in normal tissues and inflammatory tissues. The radionuclides used in labeling amino acids include O-15, N-13, C-11, I-123, F-18 and Ga-68, among which the most commonly used is F-18 . Available data support the use of certain F-18-labeled AAs for PET/CT imaging of gliomas, neuroendocrine tumors, prostate cancer and breast cancer [2, 3]. With the progress of the method of F-18 labeling AAs [4-6], F-18-labeled AAs are well established for tumor PET/CT imaging. This review focuses on the current status of key clinical applications of 18F-labeled AAs in tumor PET/CT imaging.