标题：Review Epigenetic Modifications in Hepatic Stellate Cells Contribute to Liver Fibrosis
作者：Qi Zhao;Cheng-Yong Qin;Ze-Hua Zhao;Yu-Chen Fan Kai Wang
作者机构：Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shangdong, P.R. China
通讯作者地址：[Wang, K]Shandong Univ, Qilu Hosp, Dept Hepatol, 107 Wenhuaxi Rd, Jinan 250012, Shangdong, Peoples R China.
来源：The Tohoku Journal of Experimental Medicine
关键词：epigenetic modification;gene promoter;hepatic stellate cell;liver fibrosis;methylation
摘要：Liver fibrosis is a reversible wound-healing process that occurs in almost all patients with chronic liver diseases (CLDs). The sustained liver injuries in CLDs cause multiple cells and cytokines act in a dynamic and interactive way to comprise the mechanisms of fibrogenesis. Though early-stage liver fibrosis is usually silent in symptoms, progression to cirrhosis may cause almost all kinds of hepatic complications, including portal hypertension, ascites, hepatic encephalopathy and impaired metabolic disturbance, therefore it is largely responsible for the mortality of hepatopa-thy (Mas et al. 2009; Hernandez-Gea and Friedman 2011). Activation and differentiation of hepatic stellate cells (HSCs) are core events in liver fibrosis (Fig. 1). HSCs are quiescent cells in the perisinusoidal space in liver, which facilitate hepatocytes interactions via releasing soluble inflammatory factors and producing extracellular matrix.