标题：Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer
作者：Suo, Ning; Wang, Muwen; Jin, Yang; Ding, Jun; Gao, Xueping; Sun, Xiaoliang; Zhang, Haiyang; Cui, Meng; Zheng, Jilu; Li, Nianlu; Ji 更多 作者机构：[Suo, Ning; Wang, Muwen; Jin, Yang; Sun, Xiaoliang; Zhang, Haiyang; Zheng, Jilu; Jin, Xunbo; Jiang, Shaobo] Shandong Univ, Shandong Prov Hosp, Dept Ur 更多
通讯作者：Jin, XB;Jiang, SB
通讯作者地址：[Jin, XB; Jiang, SB]Shandong Univ, Shandong Prov Hosp, Dept Urol, Jinan 250021, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF NANOMEDICINE
关键词：carbon nanotubes; intravesical instillation; epirubicin; intravesical; drug delivery
摘要：Background: Traditional intravesical instillation treatment in bladder cancer has limited efficacy, which results in a high frequency of recurrence.; Purpose: The aim of this study was to report on an epirubicin (EPI)-loaded magnetic multiwalled carbon nanotube (mMWCNTs-EPI) system for intravesical instillation in place of the current formulation.; Methods: The mMWCNTs-EPI system was formulated with carboxylated MWCNTs, Fe3O4 magnetic nanoparticles, and EPI. Features and antitumor activity of the system were investigated.; Results: Under the effect of external magnets, the mMWCNTs-EPI system showed sustained release and prolonged retention behavior and better antitumor activity than free EPI. The mMWCNTs-EPI system had higher efficiency in enhancing cytotoxicity and inhibiting proliferation in vitro and in vivo than free EPI. Our studies also revealed the atoxic nature of mMWCNTs.; Conclusion: These findings suggested that mMWCNTs are effective intravesical instillation agents with great potential for clinical application.