标题:Polymyxins: Mode of Action
作者:Li, Zhifeng; Velkov, Tony
通讯作者:Velkov, T
作者机构:[Li, Zhifeng] Shandong Univ, State Key Lab Microbial Technol, Qingdao Campus, Qingdao, Shandong, Peoples R China.; [Velkov, Tony] Univ Melbourne, De 更多
会议名称:International Conference on Polymyxins
会议日期:2018
来源:POLYMYXIN ANTIBIOTICS: FROM LABORATORY BENCH TO BEDSIDE
出版年:2019
卷:1145
页码:37-54
DOI:10.1007/978-3-030-16373-0_4
关键词:Polymyxin; LPS; Free radical; Type II NADH-quinone oxidoreductase; Outer; membrane remodelling
摘要:The dry antibiotic development pipeline coupled with the emergence of multi-drug resistant Gram-negative 'superbugs' has driven the revival of the polymyxin lipopeptide antibiotics. Understanding the mode of action of antibiotics is an important precursor for optimizing their use and development. This chapter provides a concise treatise of the current knowledge-based on the primary mode of action of polymyxins as well as recent developments in understanding of bacterial cell responses and secondary modes of action.
收录类别:CPCI-S;SCOPUS;SCIE
资源类型:会议论文;期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070489121&doi=10.1007%2f978-3-030-16373-0_4&partnerID=40&md5=d1d8267c0e336221b483a1f7edc8f299
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