标题：Traditional Chinese Medicine for Cardiovascular Disease Evidence and Potential Mechanisms
作者：Hao, Panpan; Jiang, Fan; Cheng, Jing; Ma, Lianyue; Zhang, Yun; Zhao, Yuxia
作者机构：[Hao, Panpan; Cheng, Jing; Ma, Lianyue; Zhang, Yun; Zhao, Yuxia] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist E 更多
通讯作者：Zhang, Y;Zhang, Y;Zhao, YX
通讯作者地址：[Zhang, Y]Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Educ, 107 Wen Hua Xi Rd, Jinan 250012, Shandong, Peoples 更多
来源：JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
关键词：Chinese herbal drugs; dyslipidemia; heart failure; hypertension;; randomized controlled trials as topic; type 2 diabetes mellitus
摘要：Traditional Chinese medicine (TCM) has more than 2,000 years of history and has gained widespread clinical applications. However, the explicit role of TCM in preventing and treating cardiovascular disease remains unclear due to a lack of sound scientific evidence. Currently available randomized controlled trials on TCM are flawed, with small sample sizes and diverse outcomes, making it difficult to draw definite conclusions about the actual benefits and harms of TCM. Here, we systematically assessed the efficacy and safety of TCM for cardiovascular disease, as well as the pharmacological effects of active TCM ingredients on the cardiovascular system and potential mechanisms. Results indicate that TCM might be used as a complementary and alternative approach to the primary and secondary prevention of cardiovascular disease. However, further rigorously designed randomized controlled trials are warranted to assess the effect of TCM on long-term hard endpoints in patients with cardiovascular disease. (C) 2017 by the American College of Cardiology Foundation.