标题：Recent progress of micro-needle formulations: Fabrication strategies and delivery applications
作者：Cheng, Huiling; Liu, Mengrui; Du, Xiyou; Xu, Jiangkang; Zhai, Yujia; Ji, Jianbo; He, Shuwang; Zhai, Guangxi
作者机构：[Cheng, Huiling; Liu, Mengrui; Du, Xiyou; Xu, Jiangkang; Ji, Jianbo; He, Shuwang; Zhai, Guangxi] Shandong Univ, Coll Pharm, Dept Pharmaceut, 44 Wenhua 更多
通讯作者：Zhai, GX;He, SW
通讯作者地址：[Zhai, GX]Shandong Univ, Coll Pharm, Dept Pharmaceut, 44 Wenhua Xilu, Jinan 250012, Shandong, Peoples R China;[He, SW]Shandong Dyne Marine Biopharmace 更多
来源：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
关键词：Micro-needle; Etching; Transdermal drug delivery; Biopharmaceuticals
摘要：Micro-needle (MN), a kind of micro-device, has been proposed to act as drug delivery systems since 1990s. It can be made from silicon, metal, polymer and ceramic materials. A broad range of biopharmaceuticals are delivered by MN into skin, especially the supra-molecule which can not get through the stratum corneum. MN causes less pain and increases drug absorption by orders of magnitude compared to hypodermic syringe. Several published articles in a decade have been reported, demonstrating a great progress in the design, manufacture and application of MN. This review spotlights the fabrication materials of MN, preparation methods and delivery applications of MN in human diseases. Potential safety aspects in this transdermal drug delivery systems are also described in detail.