标题:Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation
作者:Yuan, Ming-Liang; Jiang, Tian-Yu; Du, Lu-Pei; Li, Min-Yong
作者机构:[Yuan Mingliang] Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Key Laboratory of Chemical Biology (MOE), Jinan, Shandong 更多
通讯作者:Li, MY(mli@sdu.edu.cn)
通讯作者地址:[Li, MY]Shandong Univ, Sch Pharm, Key Lab Chem Biol MOE, Dept Med Chem, Jinan 250012, Peoples R China.
来源:中国化学快报
出版年:2016
卷:27
期:4
页码:550-554
DOI:10.1016/j.cclet.2016.02.011
关键词:Bioluminescence imaging; Coelenterazine derivatives; Relative quantum; yield; Chemiluminescence; Red-shifted
摘要:Replacement of the methylene group at the C-8 position with an extended electronic conjugation is a new promising method to develop red-shifted coelenterazine derivatives. In this paper, we have described an oxygen-containing coelenterazine derivative with a significant red-shifted (63 nm) bioluminescence signal maximum relative to coelenterazine 400a (DeepBlueC (TM), 1). In cell imaging, the sulfur-containing coelenterazine derivative displayed a significantly (1.77 +/- 0.09; P <= 0.01) higher luminescence signal compared to coelenterazine 400a and the oxygen-containing coelenterazine derivative exhibited a slightly (0.74 +/- 0.08; P <= 0.05) lower luminescence signal. It is beneficial to understand further the underlying mechanisms of bioluminescence. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961778228&doi=10.1016%2fj.cclet.2016.02.011&partnerID=40&md5=91ce459f5735aae2b2336a7f44b6c92c
TOP