标题：Expression of Glioma-associated Oncogene Homolog 1 is Associated with Invasion and Postoperative Liver Metastasis in Colon Cancer
作者：Ding, Yin-lu; Zhou, Yong; Xiang, Lei; Ji, Zhi-peng; Luo, Zhou-hong
作者机构：[Ding, Yin-lu; Zhou, Yong; Ji, Zhi-peng] Shandong Univ, Hosp 2, Dept Gen Surg, Jinan 250033, Shandong, Peoples R China.; [Xiang, Lei] Shandong Univ, 更多
通讯作者地址：[Ji, ZP]Shandong Univ, Hosp 2, Dept Gen Surg, Jinan 250033, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
关键词：Colon neoplasm; Glioma-associated oncogene 1; Liver metastasis
摘要：Objective: To investigate the expression of glioma-associated oncogene homolog 1(Gli-1) in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis.; Methods: Expression of Gli-1 was detected by immunohistochemistry in paraffin-embedded specimens of 96 cases of colon cancer. Relationship between Gli-1 expression and clinicopathological parameters, postoperative liver metastasis were analyzed.; Results: Gli-1 protein expression was significantly increased in colon cancer tissues compared to normal colon tissues (P = 0.037). Gli-1 expression in colon tissues was increased in patients with lymph node metastases (P = 0.022) and higher T stages (P = 0.030). Postoperative live metastasis-free survival period was significantly longer in low Gli-1 expression group than that of high Gli-1 expression group (48.22 +/- 10.03 months vs 20.46 +/- 6.32 months, P = 0.001). Multivariate analysis showed that Gli-1 expression level is an independent prognostic factor for postoperative live metastasis-free survival.; Conclusion: Colon cancer is associated with an upregulation of Gli-1 protein expression in colon tissues. In patients with colon cancer, Gli-1 expression level is closely related to lymph node metastases, T stages and postoperative live metastasis-free survival periods, indicative of a possible role of Gli-1 expression in colon cancer progression.