标题:Association of metformin use with cancer incidence and mortality: A meta-analysis
作者:Zhang,P.;Li,H.;Tan,X.;Chen,L.;Wang,S.
作者机构:[Zhang, P] Department of Epidemiology and Health Statistics, Shandong University, China;[ Li, H] Department of Haematology, Qilu Hospital, Shandong Un 更多
通讯作者:Wang, SM
通讯作者地址:[Wang, SM]44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
来源:Cancer epidemiology
出版年:2013
卷:37
期:3
页码:207-218
DOI:10.1016/j.canep.2012.12.009
关键词:Overall cancer;Site-specific cancer;Summary
摘要:Purpose: To assess the effect of metformin intake on cancer incidence and mortality. Methods: Original articles in English published until June 15, 2012 were searched for in electronic databases (MEDLINE, ISI Web of Science and EMBASE databases) and relevant reviews were examined. Meta-analysis was applied to calculate the summary relative risk (SRR) and their 95% confidence intervals (95% CI). Sensitivity analysis was conducted to assess the robustness of the pooled estimator. The risk of publication bias was assessed by the Egger regression asymmetry test. Results: According to the eligibility criteria, 37 studies comprising 1,535,636 participants, were selected in terms of intervention and data of cancer incidence or mortality. Among metformin users compared with non-users, the SRR for overall-cancer incidence was 0.73 (95% CI, 0.64-0.83) and that for mortality was 0.82 (95% CI, 0.76-0.89). The risk reductions for liver, pancreatic, colorectal and breast cancer incidence were 78%, 46%, 23% and 6%, respectively. Also, metformin can reduce the mortality of liver cancer (SRR, 0.23; 95% CI, 0.09-0.60) and breast cancer (SRR, 0.63; 95% CI, 0.40-0.99). No statistically significant association between metformin and prostate cancer incidence was found. Conclusions: Metformin can reduce the incidence of overall cancer, liver cancer, pancreatic cancer, colorectal cancer and breast cancer as well as the mortality of overall cancer, liver cancer and breast cancer. No beneficial effect on prostate cancer incidence was found for meformin intake in the meta-analysis.
收录类别:SCOPUS;SCIE
WOS核心被引频次:112
Scopus被引频次:126
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876334434&doi=10.1016%2fj.canep.2012.12.009&partnerID=40&md5=9645d5ecaf7e4cab406fd61bd7eeb5f4
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