标题:beta-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties
作者:Jin, Yiming; Li, Pingli; Wang, Fengshan
作者机构:[Jin, Yiming; Wang, Fengshan] Shandong Univ, Key Lab Chem Biol, Minist Educ, Inst Biochem & Biotechnol Drug,Sch Pharmaceut Sci, 44 Wenhuaxi Rd, Jinan 更多
通讯作者:Wang, FS
通讯作者地址:[Wang, FS]Shandong Univ, Key Lab Chem Biol, Minist Educ, Inst Biochem & Biotechnol Drug,Sch Pharmaceut Sci, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Pe 更多
来源:VACCINE
出版年:2018
卷:36
期:35
页码:5235-5244
DOI:10.1016/j.vaccine.2018.07.038
关键词:beta-glucan; Adjuvant; Vaccine; Anti-infection; Anti-tumor; Receptor;; Structure and activity relationship
摘要:beta-glucans, a group of polysaccharides exist in many organism species such as mushrooms, yeasts, oats, barley, seaweed, but not mammalians, have a variety of biological activities and applications in drugs and other healthcare products. In recent years, beta-glucans have been studied as adjuvants in anti infection vaccines as well as immunomodulators in anti-cancer immunotherapy. beta-glucans can regulate immune responses when administered alone and can connect innate and adaptive immunity to improve immunogenicity of vaccines. When beta-glucans act as immunostimulants or adjuvants, a set of receptors have been revealed to recognize beta-glucans, including dectin-1, complement receptor 3 (CR3), CD5, lactosylceramide, and so on. Therefore, this review is mainly focused on the application of beta-glucans as immune adjuvants, the receptors of beta-glucans, as well as their structure and activity relationship which will benefit future research of beta-glucans. (C) 2018 Elsevier Ltd. All rights reserved.
收录类别:SCOPUS;SCIE
WOS核心被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050237637&doi=10.1016%2fj.vaccine.2018.07.038&partnerID=40&md5=aeb473b68a09aef90185330a939c80b3
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