标题：beta-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties
作者：Jin, Yiming; Li, Pingli; Wang, Fengshan
作者机构：[Jin, Yiming; Wang, Fengshan] Shandong Univ, Key Lab Chem Biol, Minist Educ, Inst Biochem & Biotechnol Drug,Sch Pharmaceut Sci, 44 Wenhuaxi Rd, Jinan 更多
通讯作者地址：[Wang, FS]Shandong Univ, Key Lab Chem Biol, Minist Educ, Inst Biochem & Biotechnol Drug,Sch Pharmaceut Sci, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Pe 更多
关键词：beta-glucan; Adjuvant; Vaccine; Anti-infection; Anti-tumor; Receptor;; Structure and activity relationship
摘要：beta-glucans, a group of polysaccharides exist in many organism species such as mushrooms, yeasts, oats, barley, seaweed, but not mammalians, have a variety of biological activities and applications in drugs and other healthcare products. In recent years, beta-glucans have been studied as adjuvants in anti infection vaccines as well as immunomodulators in anti-cancer immunotherapy. beta-glucans can regulate immune responses when administered alone and can connect innate and adaptive immunity to improve immunogenicity of vaccines. When beta-glucans act as immunostimulants or adjuvants, a set of receptors have been revealed to recognize beta-glucans, including dectin-1, complement receptor 3 (CR3), CD5, lactosylceramide, and so on. Therefore, this review is mainly focused on the application of beta-glucans as immune adjuvants, the receptors of beta-glucans, as well as their structure and activity relationship which will benefit future research of beta-glucans. (C) 2018 Elsevier Ltd. All rights reserved.