标题:Discovery of naphthalimide conjugates as fluorescent probes for alpha(1)-adrenoceptors
作者:Zhang, Wei; Zhou, Xin-Yang; Yu, Qin-Ying; Du, Lu-Pei; Li, Min-Yong
作者机构:[Zhang Wei] Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Key Laboratory of Chemical Biology (MOE), Jinan, Shandong 2500 更多
通讯作者:Li, MY(mli@sdu.edu.cn)
通讯作者地址:[Li, MY]Shandong Univ, Dept Med Chem, Key Lab Chem Biol MOE, Sch Pharm, Jinan 250012, Peoples R China.
来源:中国化学快报
出版年:2016
卷:27
期:2
页码:185-189
DOI:10.1016/j.cclet.2015.12.002
关键词:alpha(1)-Adrenergic receptors; Fluorescent probes; High affinity; Cell; imaging
摘要:alpha(1)-Adrenoceptors (alpha(1)-ARs), including at least three subtypes, alpha(1A), alpha(1B) and alpha(1D), which play essential roles in G protein-coupled receptors (GPCRs), can convey multiple pivotal extracellular signals in varied tissues and organs. In this research, a series of napthalienide-based small-molecule fluorescent probes (1a -1f) for alpha(1)-ARs, including two parts, a pharmacophore (quinazoline and phenylpiperazine) for alpha(1)-AR recognition and a fluorophore (naphthalimide) for visualization, were designed and synthesized successfully. These compounds display excellent fluorescence property and high affinity to receptors, which were used successfully for in vitro visualization of alpha(1)-aradrenoceptors. (c) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:1
Scopus被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032142626&doi=10.1016%2fj.cclet.2015.12.002&partnerID=40&md5=c33416bf83659e8e010b1dd864c9dfcd
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