标题：Childhood trauma associates with clinical features of bipolar disorder in a sample of Chinese patients
作者：Li, Xian-Bin; Liu, Jin-Tong; Zhu, Xiong-Zhao; Zhang, Liang; Tang, Yi-Lang; Wang, Chuan-Yue
作者机构：[Li, Xian-Bin; Zhang, Liang; Wang, Chuan-Yue] Capital Med Univ, Beijing Anding Hosp, Dept Psychiat, Beijing Key Lab Mental Disorders, Beijing 100088, 更多
通讯作者地址：[Wang, CY]Capital Med Univ, Beijing Anding Hosp, 5 Ankang Lane,Dewai Ave, Beijing 100088, Peoples R China.
来源：JOURNAL OF AFFECTIVE DISORDERS
关键词：Childhood; Abuse; Neglect; Bipolar disorder; Clinical feature
摘要：Objectives: Childhood trauma is a major public health problem which has a long-term consequence, a few studies have examined the relationship between childhood trauma and clinical features of bipolar disorder, most in western culture, with no such studies done in Chinese culture.; Methods: The CTQ-SF was administered to 132 Chinese patients with DSM-IV bipolar disorder. Participants also completed the Childhood Experience of Care and Abuse Questionnaire (CECA.Q), the Impact of Events Scale-Revised (IES-R), and the State-Trait Anxiety Inventory (SIM). The CTQ-SF cut-off scores for exposure were used to calculate the prevalence of trauma. The relationship between childhood trauma and clinical features of bipolar disorder were examined.; Results: The internal consistency of CTQ-SF was good (Cronbach's alpha=0.826) and four week test-retest reliability was high (r=0,755). 61.4% of this sample reported physical neglect (PN) in childhood, followed by emotional neglect (EN, 49.6%), sexual abuse (SA, 40.5%), emotional abuse (EA, 26.0%) and physical abuse (PA,13.1%). Significant negative correlations existed between age of onset and EA and EN score (r= -0.178 similar to-0.183, p < 0.05). Significant positive correlations were observed between EA, CTQ-SF total score and intrusion and hyper-arousal scores of IES-R (r=0.223 similar to-0.309, p < 0.05). Similarly, significant positive correlations were found between EN, PN, CTQ-SF total and STAI score (r=0.222 similar to 0425, p < 005); Limitations: Data on childhood trauma were derived from a retrospective self-report questionnaire without independent corroboration. A number of potential patients (more severe or chronic patients) was excluded because they were either refused to participate or inappropriate to participate in research.; Conclusions: Significant number of subjects in patients with BD reported experience of childhood abuse and neglect Exposure to childhood trauma is associated with age of onset of illness, co morbid PTSD and anxiety symptoms. To study the pathogenesis of childhood trauma on bipolar disorder and explanation the interaction between childhood trauma and susceptibility genes are proposed. (C) 2014 Elsevier B.V. All rights reserved.