标题:Smart Polymeric Nanoparticles for Cancer Gene Delivery
作者:Lin, Guimei; Zhang, Hong; Huang, Leaf
作者机构:[Lin, Guimei; Zhang, Hong] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China.; [Zhang, Hong] Univ N Carolina, Eshelman Sch 更多
通讯作者:Lin, GM
通讯作者地址:[Lin, GM]Shandong Univ, Sch Pharmaceut Sci, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
来源:MOLECULAR PHARMACEUTICS
出版年:2015
卷:12
期:2
页码:314-321
DOI:10.1021/mp500656v
关键词:gene delivery; cancer therapy; nanoparticle
摘要:The massive amount of human genetic information already available has accelerated the identification of target genes, making gene and nucleic acid therapy the next generation of medicine. Nanoparticle (NP)-based anticancer gene therapy treatment has received significant interest in this evolving field. Recent advances in vector technology have improved gene transfection efficiencies of nonviral vectors to a level similar to viruses. This review serves as an introduction to surface modifications of NPs based on polymeric structural improvements and target moieties. A discussion regarding the future perspective of multifunctional NPs in cancer therapy is also included.
收录类别:SCOPUS;SCIE
WOS核心被引频次:34
Scopus被引频次:39
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961288317&doi=10.1021%2fmp500656v&partnerID=40&md5=cb03ba26550b0571b85ede4c7856a60b
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