标题:Design and Synthesis of Hydrazine and Oxadiazole-containing Derivatives of Sorafenib as Antitumor Agents
作者:Wang Yuan-you; Liu Jian-zhen; Yu Xiao-yue; Yang De-zhi; Zhang Lin-na; Zhao Gui-sen
作者机构:[Wang, Y.-Y] Key Laboratory of Chemical Biology, Ministry of Education, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Jinan, C 更多
通讯作者:Zhang, L(linnazhang62@yahoo.com.cn)
通讯作者地址:[Zhang, LN]Shandong Univ, Qilu Hosp, Jinan 250012, Peoples R China.
来源:高等学校化学研究(英文版)
出版年:2013
卷:29
期:3
页码:454-459
DOI:10.1007/s40242-013-2490-3
关键词:Sorafenib analog;Antiproliferative activity;Antitumor agent
摘要:A series of hydrazine and oxadiazole analogs of Sorafenib was designed, synthesized and characterized by proton nuclear magnetic resonance(H-1 NMR) spectrometry and high resolution mass spectrometry(HRMS). The antiproliferative activities of these compounds against human colorectal carcinoma(HCT-116) and human breast cancer (MDA-MB-231) tumor cell lines were evaluated in vitro by MTT method[MTT=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]. The bioassay results suggest that most of the synthesized compounds have antitumor potential to HCT-116 cell line compared with MDA-MB-231 cell line. Compounds 8a, 8b, 8d, 8e, 9f and 9j competitive with Sorafenib demonstrated antiproliferative activities on HCT-116 cell line.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84882766176&doi=10.1007%2fs40242-013-2490-3&partnerID=40&md5=03d5a83beb4cf7d937d81c2c07e2e67f
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