标题:Prognostic value of PD-1 and TIM-3 on CD3+T cells from diffuse large B-cell lymphoma
作者:Zhang, Li; Du, Hui; Xiao, Tai-wu; Liu, Ji-zhu; Liu, Guo-zhen; Wang, Jing-xia; Li, Guang-yao; Wang, Le-xin
作者机构:[Zhang, Li; Du, Hui; Xiao, Tai-wu; Liu, Ji-zhu; Liu, Guo-zhen; Wang, Jing-xia; Li, Guang-yao] Shandong Univ, Sch Med, Jinan 250012, Shandong, Peoples 更多
通讯作者:Wang, LX
通讯作者地址:[Wang, LX]Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2650, Australia.
来源:BIOMEDICINE & PHARMACOTHERAPY
出版年:2015
卷:75
页码:83-87
DOI:10.1016/j.biopha.2015.08.037
关键词:PD-1; TIM-3; Chemotherapy efficiency; Prognosis; Diffuse large B-cell; lymphoma
摘要:Objective: To investigate the expression of PD-1 and TIM-3 in CD3+ T cells in patients with diffuse large B-cell lymphoma (DLBCL).; Methods: A retrospective analysis was conducted on data from 46 patients with newly diagnosed DLBCL and 30 healthy people. Flow cytometry was used to detect the expression of PD-1 and TIM-3 before and after chemotherapy.; Results: Compared to healthy control, the expression of PD-1 and TIM-3 in patients with DLBCL was increased in CD3+ T cells. There is no significant change of PD-1 and TIM-3 in patients with stage I/II DLBCL, however, they were markedly increased in patients with stage III/IV DLBCL. The expression of PD-1 and TIM-3 elevated in DLBCL patients with B symptoms, IPI score > 2 points and high level of LDH and Ki-67. After four courses of standard chemotherapy, PD-1 and TIM-3 expression level decreased. The treatment efficiency is higher in patients with low expression of PD-1 and TIM-3 than in patients with high PD-1 and TIM-3 expression.; Conclusion: DLBCL patients have high expression level of PD-1 and TIM-3, which are related to DLBCL staging. PD-1 and TIM-3 expression levels are also related to the efficiency of chemotherapy. PD-1 and TIM-3 expression levels may be used as an indicator of chemotherapeutic efficacy in patients with DLBCL. (C) 2015 Elsevier Masson SAS. All rights reserved.
收录类别:SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944071137&doi=10.1016%2fj.biopha.2015.08.037&partnerID=40&md5=6577a2bfef2e2cf20c519baccf1b49b1
TOP