标题：Prognostic value of PD-1 and TIM-3 on CD3+T cells from diffuse large B-cell lymphoma
作者：Zhang, Li; Du, Hui; Xiao, Tai-wu; Liu, Ji-zhu; Liu, Guo-zhen; Wang, Jing-xia; Li, Guang-yao; Wang, Le-xin
作者机构：[Zhang, Li; Du, Hui; Xiao, Tai-wu; Liu, Ji-zhu; Liu, Guo-zhen; Wang, Jing-xia; Li, Guang-yao] Shandong Univ, Sch Med, Jinan 250012, Shandong, Peoples 更多
通讯作者地址：[Wang, LX]Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2650, Australia.
来源：BIOMEDICINE & PHARMACOTHERAPY
关键词：PD-1; TIM-3; Chemotherapy efficiency; Prognosis; Diffuse large B-cell; lymphoma
摘要：Objective: To investigate the expression of PD-1 and TIM-3 in CD3+ T cells in patients with diffuse large B-cell lymphoma (DLBCL).; Methods: A retrospective analysis was conducted on data from 46 patients with newly diagnosed DLBCL and 30 healthy people. Flow cytometry was used to detect the expression of PD-1 and TIM-3 before and after chemotherapy.; Results: Compared to healthy control, the expression of PD-1 and TIM-3 in patients with DLBCL was increased in CD3+ T cells. There is no significant change of PD-1 and TIM-3 in patients with stage I/II DLBCL, however, they were markedly increased in patients with stage III/IV DLBCL. The expression of PD-1 and TIM-3 elevated in DLBCL patients with B symptoms, IPI score > 2 points and high level of LDH and Ki-67. After four courses of standard chemotherapy, PD-1 and TIM-3 expression level decreased. The treatment efficiency is higher in patients with low expression of PD-1 and TIM-3 than in patients with high PD-1 and TIM-3 expression.; Conclusion: DLBCL patients have high expression level of PD-1 and TIM-3, which are related to DLBCL staging. PD-1 and TIM-3 expression levels are also related to the efficiency of chemotherapy. PD-1 and TIM-3 expression levels may be used as an indicator of chemotherapeutic efficacy in patients with DLBCL. (C) 2015 Elsevier Masson SAS. All rights reserved.