标题：Phenolic alkaloids from the aerial parts of Dracocephalum heterophyllum
作者：Wang, Limei; Wang, Shuqi; Yang, Shuang; Guo, Xiaojiang; Lou, Hongxiang; Ren, Dongmei
作者机构：[Wang, Limei; Wang, Shuqi; Yang, Shuang; Guo, Xiaojiang; Lou, Hongxiang; Ren, Dongmei] Shandong Univ, Dept Nat Prod Chem, Key Lab Chem Biol, Minist Ed 更多
通讯作者地址：[Ren, DM]Shandong Univ, Dept Nat Prod Chem, Key Lab Chem Biol, Minist Educ,Sch Pharmaceut Sci, 44 Wenhuaxi Rd, Jinan 250012, Peoples R China.
关键词：Dracocephalum heterophyllum; Lamiaceae; Flavonoidal alkaloid; Imidazole; alkaloid; Chiral HPLC; Absolute configuration
摘要：Chemical examination of aerial parts of Dracocephalum heterophyllum resulted in isolation of phenolic alkaloids, including two flavonoidal alkaloids, drahebephins A and B, one imidazole alkaloid with a phenolic substituent, drahebenine, together with 15 other known compounds. Their structures were established by extensive spectroscopic data analyses. Due to the stereogenic center in the pyrrolidin-2-one ring, the flavonoidal alkaloids are chiral, although they were isolated as racemates. The enantiomers were separated by HPLC using a chiral phase and stereochemically characterized by circular dichroism (CD) spectroscopy. The structure of compound drahebenine was established by X-ray crystallography. (C) 2012 Elsevier Ltd. All rights reserved.