标题：Human leukocyte antigen-G expression and polymorphisms promote cancer development and guide cancer diagnosis/treatment (Review)
作者：Zhang, Yanwen; Yu, Shuwen; Han, Yali; Wang, Yunshan; Sun, Yuping
作者机构：[Zhang, Yanwen] Shandong Univ, Sch Med, Dept Oncol, Jinan 250012, Shandong, Peoples R China.; [Zhang, Yanwen; Han, Yali; Sun, Yuping] Shandong Univ, 更多
通讯作者：Sun, YP;Wang, YS
通讯作者地址：[Sun, YP]Shandong Univ, Jinan Cent Hosp, Dept Oncol, 105 Jie Fang Rd, Jinan 250013, Shandong, Peoples R China;[Wang, YS]Shandong Univ, Jinan Cent Hosp 更多
关键词：human leukocyte antigen-G; cancer; genetic polymorphism; immune evasion;; tumor development; therapeutic target
摘要：Human leukocyte antigen-G (HLA-G) is a non-classical HLA molecule, predominantly expressed in cytotrophoblast cells to protect the fetus during pregnancy. Notably, a high frequency of HLA-G expression has been observed in a wide variety of cancer types in previous studies. Furthermore, HLA-G expression in cancer has been considered to be detrimental, since it can protect cancer cells from natural killer cell cytotoxic T lymphocyte-mediated destruction, promote tumor spreading and shorten the survival time of patients by facilitating tumor immune evasion. In addition, HLA-G polymorphisms have been investigated in numerous types of cancer and are considered as risk factors and predictive markers of cancer. This review focuses on HLA-G expression and its polymorphisms in cancer, analyzing the mechanisms of HLA-G in promoting cancer development, and evaluating the potential and value of its clinical application as a diagnostic and prognostic biomarker, or even as a prospective therapeutic target in certain types of tumors.