标题：TIPE2 as a potential therapeutic target in chronic viral hepatitis
作者：Ji, Jian; Zhang, Yuan-Yuan; Fan, Yu-Chen
作者机构：[Ji, Jian] Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Shandong, Peoples R China.; [Zhang, Yuan-Yuan] Shandong Univ, Dept Neurol, Jinan Cent Hos 更多
通讯作者：Fan, YC;Fan, YC
通讯作者地址：[Fan, YC]Shandong Univ, Dept Hepatol, Qilu Hosp, Wenhuaxi Rd 107, Jinan 250012, Shandong, Peoples R China;[Fan, YC]Shandong Univ, Dept Immunol, Sch Ba 更多
来源：EXPERT OPINION ON THERAPEUTIC TARGETS
关键词：Tumor necrosis factor-alpha-induced protein-8 like-2; hepatitis B virus;; hepatitis C virus; viral hepatitis; caspase-8; nuclear factor-kappa B
摘要：Introduction: Tumor necrosis factor-alpha-induced protein-8 like-2 (TIPE2) is a novel negative regulator of innate and adaptive immune responses by binding to caspase-8. The binding of TIPE2 and caspase-8 can inhibit the activity of activating protein-1(AP-1) and nuclear factor-kappa B (NF-kappa B), ultimately promoting Fas-induced apoptosis in immune cells. Therefore, TIPE2-caspase-8-NF-kappa B signaling might serve as a biomarker and a potential target for therapeutic intervention. Areas covered: This review summarizes the biological functions of TIPE2 in the regulation of immune homeostasis and the underlying mechanism by which TIPE2 is regulated in the human immune response. The molecular pathway of TIPE2-caspase-8 signaling in chronic infections of hepatitis B virus and hepatitis C virus is also explained. Expert opinion: Considering the essential role of TIPE2 in linking immunity and inflammation, this protein may be a promising therapeutic target in chronic viral hepatitis. However, studies are necessary to elucidate the molecular mechanism of TIPE2 in the immunogenesis of viral hepatitis and to develop potential interventions for breaking immune tolerance in chronic hepatitis B virus infection. Additional studies are required to understand how TIPE2 binds to caspase-8.