标题：Advances in immunopathogenesis of adult immune thrombocytopenia
作者：Liu X.; Hou Y.; Peng J.
作者机构：[Liu, X] Department of Hematology, Qilu Hospital, Shandong University, Jinan, 250012, China;[ Hou, Y] Shandong University School of Medicine, Jinan, 2 更多
通讯作者地址：[Peng, J] Department of Hematology, Qilu Hospital, Shandong University, Jinan, 250012, China;
来源：Frontiers of Medicine in China
关键词：antigen-presenting cells; B lymphocytes; cytokines; primary immune thrombocytopenia; T lymphocytes
摘要：Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated accelerated platelet destruction and/or suppressed platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified, and the pathways behind the immune-mediated destruction of platelets have opened new avenues for the design of specific immunotherapies in an attempt to reduce the platelet destruction. This review is primarily focused on the recent literature with respect to immunopathological mechanisms in patients with ITP. © 2013 Higher Education Press and Springer-Verlag Berlin Heidelberg.