标题：Synthesis and Characterization of pH-Responsive Block Copolymers with Primary Amine Groups
作者：Wang Hong; Zhu Yue-jun; Ren Xiao-na; Zhang Hong; Tan Ye-bang
作者机构：[Wang, H] Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong Uni 更多
通讯作者地址：[Tan, YB]Shandong Univ, Minist Educ, Sch Chem & Chem Engn, Key Lab Special Funct Aggregated Mat, Jinan 250100, Peoples R China.
关键词：Block copolymer;Polyamine;pH-Responsive;Water soluble copolymer
摘要：A new pH-responsive block copolymer, methoxy poly(ethylene glycol)-b-poly[5-methacrylamidopentylamine hydrochloride](mPEG-b-PMAAPA) was synthesized and characterized in this paper. The monomer 5-methacrylamido-pentylamine hydrochloride(MAAPA) and the macroinitiator(mPEG-ACVA) were synthesized, respectively, and mPEG-b-PMAAPA was then obtained by free radical polymerization. The structure and molecular weight of mPEG-b-PMAAPA were confirmed by hydrogen nuclear magnetic resonance(H-1 NMR) spectroscopy and gel permeation chromatography with multiangle laser light scattering(GPC-MALLS) measurements. At a low pH, it is hydrophilic due to the protonation of the primary amine groups. With increasing pH value, deprotonation occurs and the hydrophobicity of PMAAPA block increases. This molecular feature leads to interesting aggregation behavior of mPEG-b-PMAAPA in aqueous solutions at different pH values as revealed by dynamic light scattering(DLS) measurements, transmission electron microscopy(TEM) observations and resonance light scattering(RLS) measurements.