标题:Ectopic Expression of TIM-3 in Lung Cancers A Potential Independent Prognostic Factor for Patients With NSCLC
作者:Zhuang, Xuewei; Zhang, Xiaoning; Xia, Xiyan; Zhang, Cuijuan; Liang, Xiaohong; Gao, Lifen; Zhang, Xin; Ma, Chunhong
作者机构:[Zhuang, Xuewei; Zhang, Xiaoning; Liang, Xiaohong; Gao, Lifen; Zhang, Xin; Ma, Chunhong] Shandong Univ, Key Lab Expt Teratol, Minist Educ, Sch Med, Ji 更多
通讯作者:Ma, CH
通讯作者地址:[Ma, CH]Shandong Univ, Key Lab Expt Teratol, Minist Educ, Sch Med, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
来源:AMERICAN JOURNAL OF CLINICAL PATHOLOGY
出版年:2012
卷:137
期:6
页码:978-985
DOI:10.1309/AJCP9Q6OVLVSHTMY
关键词:T-cell immunoglobulin mucin domain-3; Non-small cell lung cancer;; Survival rate; Prognosis
摘要:T-cell immunoglobulin- and mucin domain-3-containing molecule 3 (TIM-3) is a membrane protein expressed in various kinds of immune cells and plays a pivotal role in immune regulation. Recently, TIM-3 was reported to be expressed aberrantly in melanoma cells, contributing to the low adhesion ability of tumor cells and promoting the survival of melanoma cells. We investigated TIM-3 expression in non small cell lung cancers (NSCLCs), and further analyzed whether the aberrant expression of TIM-3 is related to the prognosis for patients with lung cancer. Tumor tissue samples from 30 patients with NSCLC were involved. Results of immunohistochemical analysis showed that TIM-3 stained positive on tumor cells in 86.7% (26/30) patients with primary NSCLC. The TIM-3 expression in NSCLC tumor cells was correlated with histologic type and pathologic T classification of the disease (P < .05). More importantly, patients with TIM-3 positive tumor cells had a significantly shorter survival time than those with TIM-3-negative tumors. Multivariate analysis demonstrated the significant role of TIM-3 expression in tumor cells as an independent prognostic factor for patients with NSCLC (relative risk, 4.481; 95% confidence interval, 1.790-11.22; P = .0005). Our results suggest that the ectopic expression of TIM-3 in tumor cells may be a potential, independent prognostic factor for patients with NSCLC.
收录类别:SCOPUS;SCIE
WOS核心被引频次:41
Scopus被引频次:44
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864214537&doi=10.1309%2fAJCP9Q6OVLVSHTMY&partnerID=40&md5=00643b97993e99bff1c319460ebc1145
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