标题：Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats
作者：Lin Zhang;Junxia Luo;Minghua Zhang;Wei Yao;Xuelian Ma;Shu Yan Yu
作者机构：[Zhang, L] Department of Physiology, Shandong University, School of Medicine, Wenhuaxilu Road, Jinan, Shandong Province, 250012, China;[ Luo, J] Depar 更多
通讯作者地址：[Yu, SY]Shandong Univ, Sch Med, Dept Physiol, Wenhuaxilu Rd, Jinan 250012, Shandong, Peoples R China.
来源：The international journal of neuropsychopharmacology
关键词：Brain-derived neurotrophic factor;chronic unpredictable mild stress;curcumin;lateral amygdala;structural plasticity.
摘要：Depression is a neuropsychiatric disease associated with wide ranging disruptions in neuronal plasticity throughout the brain. Curcumin, a natural polyphenolic compound of curcuma loga, has been demonstrated to be effective in the treatment of depressive-like disorders. The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of curcumin in a rat model of chronic, unpredictable, mild, stress (CUMS) -induced depression. The results showed that CUMS produced depressive-like behaviours in rats, which were associated with ultra-structural changes in neurons within the lateral amygdala (LA). In addition, the expression of synapse-associated proteins such as brain-derived neurotrophic factor (BDNF), PSD-95 and synap-tophysin were significantly decreased in the LA of CUMS-treated rats. Chronic administration of curcumin (40mg/kg, i.p. 6wk) before stress exposure significantly prevented these neuronal and biochemical alterations induced by CUMS, and suppressed depressive-like behaviours, suggesting that this neuronal dysregulation may be related to the depressive-like behaviours caused by CUMS. Together with our previous results, the current findings demonstrate that curcumin exhibits neuroprotection and antidepressant-like effects in the CUMS-induced depression model. Furthermore, this antidepressant-like action of curcumin appears to be mediated by modulating synapse-associated proteins within the LA. These findings provide new insights into the underlying mechanisms leading to neural dysfunction in depression and reveal the therapeutic potential for curcumin use in clinical trials.