标题：A case report of metastatic bilateral ovarian cancer due to non-small cell lung cancer with ALK gene rearrangement
作者：Liu, Zhitong; Liu, Bo; Li, Changzhong
作者机构：[Liu, Zhitong; Li, Changzhong] Shandong Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.; [Liu, Bo] Shandong Univ, Shandong Acad Med Sci, 更多
通讯作者地址：[Liu, B]Shandong Univ, Shandong Acad Med Sci, Shandong Canc Hosp, Ji Yan Rd 440, Jinan 250117, Shandong, Peoples R China.
来源：EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
关键词：Metastatic bilateral ovarian cancer; Non-small cell lung cancer (NSCLC);; Adenocarcinoma of lung; ALK gene rearrangement; Crizotinib
摘要：Ovarian cancer patients are becoming more and more frequent; a part of them are metastatic ovarian cancer patients, which mostly come from colon, stomach, appendix, and pancreas, rarely come from lung. The authors report a case of metastatic bilateral ovarian cancer due to non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK) gene rearrangement. This female patient was diagnosed with adenocarcinoma of lung (cT3N2M1 Stage IV) and received chemotherapy and targeted drug therapy. She was diagnosed with metastatic ovarian cancer from lung by CT, and puncture biopsy and pathologic examination after surgery. Cancer gene detection confirmed ALK gene rearrangement. ALK gene rearrangement may increase the rate of metastasis of lung cancer, and as the target spot of tumor targeted therapy, it may provide an important treatment method for primary tumor and metastasis.