标题：Bioactive natural products from Lysobacter
作者机构：[Xie, Y] Department of Chemistry, University of Nebraska, Lincoln NE 68588, United States;[ Wright, S] Department of Chemistry, University of Nebraska 更多
通讯作者地址：[Du, LC]Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA.
来源：Natural product reports
摘要：Covering: up to March 2012 The gliding Gram-negative Lysobacter bacteria are emerging as a promising source of new bioactive natural products. These ubiquitous freshwater and soil microorganisms are fast growing, simple to use and maintain, and genetically amenable for biosynthetic engineering. This Highlight reviews a group of biologically active and structurally distinct natural products from the genus Lysobacter, with a focus on their biosyntheses. Although Lysobacter sp. are known as prolific producers of bioactive natural products, detailed molecular mechanistic studies of their enzymatic assembly have been surprisingly scarce. We hope to provide a snapshot of the important work done on the lysobacterial natural products and to provide useful information for future biosynthetic engineering of novel antibiotics in Lysobacter.