标题:ALDH2---The Genetic Polymorphism and Enzymatic Activity Regulation: Their Epidemiologic and Clinical Implications
作者:Zhang, Rui; Wang, Jiali; Xue, Mengyang; Xu, Feng; Chen, Yuguo
作者机构:[Zhang, Rui; Wang, Jiali; Xue, Mengyang; Xu, Feng; Chen, Yuguo] Shandong Univ, Qilu Hosp, Dept Emergency, Jinan, Shandong, Peoples R China.; [Zhang, 更多
通讯作者:Xu, F;Chen, YG
通讯作者地址:[Xu, F; Chen, YG]Shandong Univ, Qilu Hosp, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
来源:CURRENT DRUG TARGETS
出版年:2017
卷:18
期:15
页码:1810-1816
DOI:10.2174/1389450116666150727115118
关键词:Aldehyde dehydrogenase 2 (ALDH2); ALDH2 activator; ALDH2 inhibitor;; genetic polymorphism; Mendelian randomization; observational; epidemiology
摘要:Background: The human aldehyde dehydrogenase 2 (ALDH2) is the most effective enzyme in the detoxification of alcohol metabolite acetaldehyde. The ALDH2*2 mutation is caused by a single nucleotide substitution which results in a nearly inactive form of ALDH2 enzyme. The ALDH2 genotype has been used as a surrogate of alcohol to get causal inferences of alcohol in related diseases implementing Mendelian randomization approach. In addition, ALDH2 enzyme has significant effect on different diseases, indicating the potential therapeutic value of ALDH2 regulators including both activators like Alda-1 and inhibitors such as daidzin and daidzein.; Objective: In this review, we aim to systematically discuss the implications of ALDH2 genotype and ALDH2 enzyme regulators, highlighting their epidemiological and clinical importance, respectively.; Conclusion: ALDH2 polymorphism is shown to be a genetic instrument for alcohol use in Mendelian randomization analysis. ALDH2 regulators exhibit potential therapeutic value as the important roles of ALDH2 in various diseases. Both the genetic polymorphism and enzyme activity regulation of ALDH2 are of great importance to their epidemiologic and clinical applications.
收录类别:SCOPUS;SCIE
WOS核心被引频次:1
Scopus被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039994082&doi=10.2174%2f1389450116666150727115118&partnerID=40&md5=c0c9e2ec96483c7e6e398c60f89353ef
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