标题：Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases
作者：Ge, Di; Yue, Hong-wei; Liu, Hong-hong; Zhao, Jing
作者机构：[Ge, Di] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China.; [Ge, Di; Yue, Hong-wei; Liu, Hong-hong; Zhao, Jing] Shandong 更多
通讯作者：Ge, D;Ge, D;Zhao, J
通讯作者地址：[Ge, D]Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China;[Ge, D; Zhao, J]Shandong Univ, Sch Life Sci, Shandong Prov Key Lab 更多
来源：ACTA PHARMACOLOGICA SINICA
关键词：sphingosylphosphorylcholine; sphingolipid; second messenger; first; messenger; G protein-coupled receptor; membrane lipid raft; myocytes;; vein endothelial cell; vascular smooth muscle cells
摘要：Sphingosylphosphorylcholine (SPC) is a bioactive sphingolipid in blood plasma that is metabolized from the hydrolysis of the membrane sphingolipid. SPC maintains low levels in the circulation under normal conditions, which makes studying its origin and action difficult. In recent years, however, it has been revealed that SPC may act as a first messenger through G protein-coupled receptors (S1P(1-5), GPR12) or membrane lipid rafts, or as a second messenger mediating intracellular Ca2+ release in diverse human organ systems. SPC is a constituent of lipoproteins, and the activation of platelets promotes the release of SPC into blood, both implying a certain effect of SPC in modulating the pathological process of the heart and vessels. A line of evidence indeed confirms that SPC exerts a pronounced influence on the cardiovascular system through modulation of the functions of myocytes, vein endothelial cells, as well as vascular smooth muscle cells. In this review we summarize the current knowledge of the potential roles of SPC in the development of cardiovascular diseases and discuss the possible underlying mechanisms.