标题:Two new apotirucallane-type isomeric triterpenoids from the root bark of Dictamnus dasycarpus with their anti-proliferative activity
作者:Bai, Yuanyuan; Jin, Xing; Jia, Xianhui; Tang, Wenzhao; Wang, Xiaojing; Zhao, Yunxue
作者机构:[Bai, Yuanyuan; Jia, Xianhui; Tang, Wenzhao; Wang, Xiaojing] Shandong Acad Med Sci, Inst Mat Med, Key Lab Rare Dis Shandong Prov, Jinan 260062, People 更多
通讯作者:Tang, WZ
通讯作者地址:[Tang, WZ]Shandong Acad Med Sci, Inst Mat Med, Key Lab Rare Dis Shandong Prov, Jinan 260062, Peoples R China.
来源:PHYTOCHEMISTRY LETTERS
出版年:2014
卷:10
页码:118-122
DOI:10.1016/j.phytol.2014.06.017
关键词:Dictamnus dasycarpus Turcz; Apotirucallane-type isomeric triterpenoids;; Dictamnin A; Dictamnin B; Antiproliferative activity
摘要:Two new apotirucallane-type isomeric triterpenoids, named as dictamnin A (1) and dictamnin B (2), with six limonoids, obacunone (3), limonin (4), rutaevin (5), 7 alpha-obacunyl acetate (6), fraxinellone (7), fraxinellonone (8), were isolated from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae). Their structures were well determined by means of IR, MS, 1D and 2D NMR techniques. Both new apotirucallane-type isomeric triterpenoids displayed good antiproliferative effects on lung cancer cells A549 and resulted in a clear increase of the percentage of cells in G1 phase and a decrease in the percentage of cells in S and G2/M phases in comparison with control cells. (C) 2014 Published by Elsevier B.V. on behalf of Phytochemical Society of Europe.
收录类别:SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84907210180&doi=10.1016%2fj.phytol.2014.06.017&partnerID=40&md5=3682f4b45949e58f5c8524bc583e7e7a
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