标题:Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm
作者:Wang, F.; Quan, Q. Q.; Zhang, C. L.; Li, Y. B.; Jiang, T. B.
作者机构:[Wang, F.; Quan, Q. Q.; Zhang, C. L.; Li, Y. B.; Jiang, T. B.] Shandong Univ, Linyi People Hosp, Dept Vasc Intervent Surg, Linyi, Shandong, Peoples R 更多
通讯作者:Zhang, CL
通讯作者地址:[Zhang, CL]Shandong Univ, Linyi People Hosp, Dept Vasc Intervent Surg, Linyi, Shandong, Peoples R China.
来源:GENETICS AND MOLECULAR RESEARCH
出版年:2015
卷:14
期:4
页码:17599-17604
DOI:10.4238/2015.December.21.32
关键词:Interleukin-10; Polymorphism; Abdominal aortic aneurysm
摘要:In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population. Three hundred and eighty-one patients with abdominal aortic aneurysm and age-and gender-matched healthy controls (N = 381) were collected between March 2012 and March 2014. The IL-10 -1082G/A, -819T/C, and -592A/C polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Logistic regression analyses revealed that the AA genotype of IL-10 -1082G/A was associated with an increased risk of abdominal aortic aneurysm compared to the GG genotype in a codominant model [odds ratio (OR) = 1.64, 95% confidence interval (CI) = 1.04-2.60]. Moreover, the GA+AA genotype was correlated with an elevated risk of abdominal aortic aneurysm compared to the GG genotype in a dominant model (OR = 1.34, 95% CI = 1.01-1.79). In conclusion, the results of our study suggested that the A allele of IL-10 -1082G/A is significantly associated with the development of abdominal aortic aneurysm compared to the wide-type genotype.
收录类别:SCOPUS;SCIE
WOS核心被引频次:1
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84951759478&doi=10.4238%2f2015.December.21.32&partnerID=40&md5=8eae085825d251d39ad251059caf880e
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