标题：Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm
作者：Wang, F.; Quan, Q. Q.; Zhang, C. L.; Li, Y. B.; Jiang, T. B.
作者机构：[Wang, F.; Quan, Q. Q.; Zhang, C. L.; Li, Y. B.; Jiang, T. B.] Shandong Univ, Linyi People Hosp, Dept Vasc Intervent Surg, Linyi, Shandong, Peoples R 更多
通讯作者地址：[Zhang, CL]Shandong Univ, Linyi People Hosp, Dept Vasc Intervent Surg, Linyi, Shandong, Peoples R China.
来源：GENETICS AND MOLECULAR RESEARCH
关键词：Interleukin-10; Polymorphism; Abdominal aortic aneurysm
摘要：In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population. Three hundred and eighty-one patients with abdominal aortic aneurysm and age-and gender-matched healthy controls (N = 381) were collected between March 2012 and March 2014. The IL-10 -1082G/A, -819T/C, and -592A/C polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Logistic regression analyses revealed that the AA genotype of IL-10 -1082G/A was associated with an increased risk of abdominal aortic aneurysm compared to the GG genotype in a codominant model [odds ratio (OR) = 1.64, 95% confidence interval (CI) = 1.04-2.60]. Moreover, the GA+AA genotype was correlated with an elevated risk of abdominal aortic aneurysm compared to the GG genotype in a dominant model (OR = 1.34, 95% CI = 1.01-1.79). In conclusion, the results of our study suggested that the A allele of IL-10 -1082G/A is significantly associated with the development of abdominal aortic aneurysm compared to the wide-type genotype.