标题:Neutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia
作者:Hu, Yu;Wang, Xiuwen;Yu, Shuang;Hou, Yu;Ma, Daoxin;Hou, Ming
作者机构:[Hu, Y] Shandong University, Qilu Hospital, Department of Hematology, Jinan, China, Shandong University, Qilu Hospital, Department of Chemotherapy, Ji 更多
通讯作者:Ma, DX
通讯作者地址:[Ma, DX]Shandong Univ, Qilu Hosp, Dept Hematol, Jinan 250100, Peoples R China.
来源:Expert opinion on therapeutic targets
出版年:2015
卷:19
期:6
页码:723-732
DOI:10.1517/14728222.2015.1016499
关键词:immune thrombocytopenia;regulatory T cell;T-helper 17;T-helper 17 cytokines
摘要:Objective: The imbalance of regulatory T cell/T-helper 17 (Treg/Th17) is critical for the pathogenesis of immune thrombocytopenia (ITP) and IL-17A and IL-21 are overexpressed in ITP. The effects and mechanisms of IL-17A and IL-21 in Treg/Th17 imbalance and ITP pathophysiology are not clarified.
收录类别:SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929582610&doi=10.1517%2f14728222.2015.1016499&partnerID=40&md5=5829d1ff64eddbd070a7685200002b43
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