标题：The potential role of preventing atherosclerosis by induction of neonatal tolerance to VLDL
作者：Cui, Kai; Hou, Guihua; Feng, Yueqiu; Liang, Ting; Kong, Feng; Sun, Lin; Wang, Shumei
作者机构：[Cui, Kai; Feng, Yueqiu; Sun, Lin; Wang, Shumei] Shandong Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Jinan 250012, Shandong, Peoples R China.; [ 更多
通讯作者地址：[Wang, SM]Shandong Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Jinan 250012, Shandong, Peoples R China.
关键词：Immune tolerance; ox-LDL; VLDL; Vaccination
摘要：Induction of immune tolerance to ox-LDL could reduce atherosclerosis by modulation immune response. We suppose that very low density lipoprotein (VLDL) may have a similar role to ox-LDL in autoimmune response of atherosclerosis. In this study, neonatal rats were injected with ox-LDL, VLDL, or equal-volume saline, respectively. Vaccination with ox-LDL reduced the level of specific antibody, T cells proliferation response, and the level of endothelins. The method also had a tendency of reducing blood lipids. Vaccination with VLDL obviously reduced the level of specific antibody and T cells proliferation. Though there was also a tendency of reducing blood lipids and endothelins, the effect was less prominent than that with ox-LDL. We conclude that, although the effect was less obvious, vaccination with VLDL to induce neonatal tolerance had an effect on modulating immune response, protecting endothelial cells, and reducing blood lipids. (C) 2011 Elsevier Inc. All rights reserved.