标题: RSF-1 overexpression determines cancer progression and drug resistance in cervical cancer.
作者: Wang, Xiangyu; Sheu, Jim Jinn-Chyuan; Lai, Ming-Tsung; Yin-Yi Chang, Cherry; Sheng, Xiugui; Wei, Ling; Gao, Yongsheng; Wang, Xingwu; Liu, Naifu; Xie, 更多
作者机构:[ Wang, Xiangyu; Wang X] School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250022, China - Departm 更多
来源: BioMedicine
出版年:2018
卷: 8
期: 1
DOI:10.1051/bmdcn/2018080104
摘要: BACKGROUND: Remodeling spacing factor 1 (RSF-1/HBXAP) has been linked to a variety of cancer types, however, its roles and the therapeutic potential are not clear in cervical cancer. METHODS: RSF-1 expression in cancer tissues was analyzed by immunohistochemical staining followed by statistical analysis with SPSS. Anti-RSF-1 studies were performed by treating cells with specific siRNA or a dominant mutant form (RSF-D4). RESULTS: RSF-1 expression correlates with cancer progression that strongly-positive staining can be found in 67.7% carcinomas and 66.7% CIN lesions, but none in normal tissues. Such overexpression also associated with increased tumor size, poor differentiation, higher nodal metastasis and advanced clinical stages. Kaplan- Meier analysis confirmed that cancer patients with high RSF-1 levels exhibited a significantly shorter survival time than those with low RSF-1 levels. Downregulation of RSF-1 by siRNA silencing or RSF-D4 reduced cell growth and increased drug sensitivity toward paclitaxel treatment in HeLa cells. CONCLUSIONS: RSF-1 participates in the tumor progression of cervical cancer and could be considered as an early prognostic marker for cancer development and clinical outcome. Therapies based on anti-RSF-1 activity may be beneficial for patients with RSF-1 overexpression in their tumors.
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资源类型:期刊论文
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