标题:The involvement of post-translational modifications in cardiovascular pathologies: Focus on SUMOylation, neddylation, succinylation, and prenylation
作者:Gao J.; Shao K.; Chen X.; Li Z.; Liu Z.; Yu Z.; Aung L.H.H.; Wang Y.;等
作者机构:[Gao, J] Center for Molecular Genetics, Institute for Translational Medicine, Faculty of Medicine, Qingdao University, Qingdao, 266021, China;[ Shao, 更多
通讯作者:Gao, J(gjn.1127@163.com)
通讯作者地址:[Gao, J] Center for Molecular Genetics, Institute for Translational Medicine, Faculty of Medicine, Qingdao UniversityChina;
来源:Journal of Molecular and Cellular Cardiology
出版年:2020
卷:138
页码:49-58
DOI:10.1016/j.yjmcc.2019.11.146
关键词:Cardiovascular disease; Neddylation; Post-translational modification; Prenylation; Succinylation; SUMOylation
摘要:Cardiovascular disease (CVD) is one of the most threatening diseases to human health and life, and the number of patients is increasing year by year. Thus, it is of great significance to study the pathogenesis, prevention and treatment of CVDs. The occurrence and development of CVDs involve dynamic, complex and delicate intracellular processes and the pathogenesis is not entirely clear. In contrast to genetic mutations, most of the protein post-translational modifications (PTMs) are reversible, and can affect the activity, stability, subcellular localization, protein-protein interaction etc., of the substrate targets, emerging as key mediators of a number of CVD progression. Under pathological conditions, the PTMs undergo aberrant balances which cause changes of the substrate target proteins in expression level, localization and capacity to activate downstream signaling pathways. Therefore, new approaches can be created aiming to correct the abnormal PTM alterations in treating CVDs. This review summarizes some of the more recent advances in PTMs, focusing on SUMOylation, neddylation, succinylation, and prenylation, and the effect of these modifications on cardiovascular function and progression, which may provide potential targets for future therapeutics. © 2019 Elsevier Ltd
收录类别:SCOPUS
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075265562&doi=10.1016%2fj.yjmcc.2019.11.146&partnerID=40&md5=6c6acea604afe44627329716479a7625
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