标题：Effects of electroacupuncture on microcirculatory blood flow and glucose transporter function in the hippocampus
作者：Lu, Yan; Han, Bingbing; Wang, Shijun
作者机构：Department of Experimental Acupuncturology, Acupuncture and Moxibustion College, Shandong University of Traditional Chinese Medi
通讯作者地址：[Wang, SJ]Shandong Univ Tradit Chinese Med, Dept Expt Acupuncturol, Acupuncture & Moxibust Coll, Jinan 250355, Shandong, Peoples R China.
关键词：Electroacupuncture;Neiguan(PC 6);focal cerebral ischemia;microvascular endothelial cells;glucose transporter 1;cerebral blood flow;CA1 region;neural regeneration
摘要：Nerve cell metabolism in post brain ischemia depends on increased microcirculation perfusion and transport function of microvascular endothelial cells. In the present study, a rat model of middle cerebral artery occlusion was established to investigate the influence of electroacupuncture(EA)on hippocampal CA1 cerebral blood flow and glucose transporter 1(GLUT1)expression in the microvascular endothelial cp.lls. Following EA at Neiguan(PC 6), the cerebral blood flow in the ischemic hippocampal CA1 region was significantly elevated, the number and microvascular integrated absorbance of the GLUTl-positive cells were significantly increased, nerve cell damage was ameliorated, and GLUT1 protein expression in the ischemic hippocampus was significantly increased. Results demonstrate that EA increased the cerebral blood flow of the hippocampal CA1 region and improved the glucose transport function, thereby attenuating neuronal injuries.