标题:Interval and continuous exercise overcome memory deficits related to β-Amyloid accumulation through modulating mitochondrial dynamics
作者:Li B.; Liang F.; Ding X.; Yan Q.; Zhao Y.; Zhang X.; Bai Y.; Huang T.;等
作者机构:[Li, B] Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, Chi 更多
通讯作者:Huang, T(taohuang@sjtu.edu.cn)
通讯作者地址:[Huang, T] Department of Physical Education, Shanghai Jiao Tong University, No.800 Dongchuang Rd, China;
来源:Behavioural Brain Research
出版年:2019
卷:376
DOI:10.1016/j.bbr.2019.112171
关键词:Alzheimer's disease; Exercise; High-intensity interval training; Mitochondrial fusion/fission; Moderate-intensity continuous training
摘要:Exercise is a non-pharmacological strategy that may help to protect against cognitive decline and reduce the risk of Alzheimer's disease. However, the optimal exercise modes for cognitive benefits are controversial. Mitochondrial function has been related to both exercise and cognition. The present study aimed to investigate the effects of two exercise modes on cognitive function and mitochondrial dynamics in APP/PS1 transgenic mice. The results showed that 12-week high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) could improve exploratory behavior, spatial learning and memory ability of APP/PS1 transgenic mice. Both HIIT and MICT interventions significantly alleviated the hippocampal β-Amyloid (Aβ) burden and mitochondrial fragmentation and improved mitochondrial morphology in hippocampus. Furthermore, both HIIT and MICT interventions down-regulated dynamin-related protein 1 (DRP1) and fission 1 (FIS1), whereas mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1) were up-regulated. Hippocampal levels of total reactive oxygen species (ROS), malondialdehyde (MDA) and hydrogen peroxide (H2O2) were decreased, whereas activities of superoxide dismutase (SOD) and catalase (CAT) were elevated by HIIT and MICT. The study suggests that both HIIT and MICT alleviate cognitive decline and down-regulat Aβ level in the hippocampus in APP/PS1 transgenic mice, which may be mediated by improvements in mitochondrial morphology and dynamics. © 2019
收录类别:SCOPUS
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071873777&doi=10.1016%2fj.bbr.2019.112171&partnerID=40&md5=7a66c3d0044d6bc69bef4b188371a9bc
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