标题：Bioavailability of Quercetin: Problems and Promises
作者：Cai, X.; Fang, Z.; Dou, J.; Yu, A.; Zhai, G.
作者机构：[Cai, X.; Dou, J.; Yu, A.; Zhai, G.] Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China.; [Fang, Z.] Shandong Univ, Coll Phar 更多
通讯作者地址：[Zhai, G]Shandong Univ, Coll Pharm, Dept Pharmaceut, 44 Wenhua Xilu, Jinan 250012, Peoples R China.
来源：CURRENT MEDICINAL CHEMISTRY
关键词：Bioavilability; formulations; inclusion complexes; liposomes; micelles;; nanoparticles; prodrug; quercetin; solubility
摘要：Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.