标题:Bioavailability of Quercetin: Problems and Promises
作者:Cai, X.; Fang, Z.; Dou, J.; Yu, A.; Zhai, G.
作者机构:[Cai, X.; Dou, J.; Yu, A.; Zhai, G.] Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China.; [Fang, Z.] Shandong Univ, Coll Phar 更多
通讯作者:Zhai, G
通讯作者地址:[Zhai, G]Shandong Univ, Coll Pharm, Dept Pharmaceut, 44 Wenhua Xilu, Jinan 250012, Peoples R China.
来源:CURRENT MEDICINAL CHEMISTRY
出版年:2013
卷:20
期:20
页码:2572-2582
DOI:10.2174/09298673113209990120
关键词:Bioavilability; formulations; inclusion complexes; liposomes; micelles;; nanoparticles; prodrug; quercetin; solubility
摘要:Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.
收录类别:SCOPUS;SCIE
WOS核心被引频次:81
Scopus被引频次:84
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877998754&doi=10.2174%2f09298673113209990120&partnerID=40&md5=06d08cd6d650aa2cbe822138c2b4aed8
TOP