标题：Novel insights into DNA methylation and its critical implications in diabetic vascular complications
作者：Zheng, Jia; Cheng, Jing; Zhang, Qian; Xiao, Xinhua
作者机构：[Zheng, Jia; Zhang, Qian; Xiao, Xinhua] Chinese Acad Med Sci, Minist Hlth, Peking Union Med Coll Hosp,Diabet Res Ctr, Dept Endocrinol,Key Lab Endocrin 更多
通讯作者：Xiao, XH;Xiao, XH
通讯作者地址：[Xiao, XH]Chinese Acad Med Sci, Minist Hlth, Peking Union Med Coll Hosp,Diabet Res Ctr, Dept Endocrinol,Key Lab Endocrinol, Beijing 100730, Peoples R 更多
摘要：Recent epidemiological and clinical studies have shown that type 2 diabetic patients can develop diabetic vascular complications even after intensive glycaemic control. It has been suggested that this phenomenon could be explained by the hypothesis of 'metabolic memory'. The underlying mechanisms between these enduring effects and the prior hyperglycaemic state are still not well understood. Preliminary studies demonstrate that hyperglycaemia can regulate gene expression by epigenetic modifications, such as DNAmethylation, which can persistently exist even after glucose normalization. Increasing evidence shows that epigenetic mechanisms may play a substantial role in the pathophysiology of diabetes and its associated vascular complications, including atherosclerosis, diabetic cardiomyopathy (DCM), nephropathy and retinopathy. In this review, we will examine the growing role of DNA methylation in diabetes and its vascular complications, thus it can provide critical implications for the early prevention of diabetes and its vascular complications.