标题：Borderline ER-Positive Primary Breast Cancer Gains No Significant Survival Benefit From Endocrine Therapy: A Systematic Review and Meta-Analysis
作者：Chen, Tong; Zhang, Ning; Moran, Meena S.; Su, Peng; Haffty, Bruce G.; Yang, Qifeng
作者机构：[Chen, Tong; Zhang, Ning; Yang, Qifeng] Shandong Univ, Qilu Hosp, Dept Breast Surg, Wenhua Xi Rd 107, Jinan 250012, Shandong, Peoples R China.; [Mor 更多
通讯作者地址：[Yang, QF]Shandong Univ, Qilu Hosp, Dept Breast Surg, Wenhua Xi Rd 107, Jinan 250012, Shandong, Peoples R China.
来源：CLINICAL BREAST CANCER
关键词：Borderline estrogen receptor; Breast carcinoma; Endocrine treatment;; Immunohistochemical staining; Prognosis
摘要：Endocrine responsiveness of primary breast cancers with borderline estrogen receptor expression (ER+ [1%-9%]) remains unclear. We aimed at investigating differences in endocrine responsiveness, prognosis, and clinicopathological characteristics between the ER+ (1%-9%) cohort and the ER- cohort or ER+ (>= 10%) cohort. Eligible literature published from inception to November 20, 2016 was retrieved from the PubMed database on the basis of Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data on survival outcomes were extracted and pooled odds ratios (ORs), 95% confidence intervals (CIs), and 2-tailed P values are reported. P values of the c 2 test for comparison of clinicopathological characteristics among included patients in the ER+ (1%-9%) cohort and the other 2 cohorts were calculated respectively. The analysis included 6 studies with 16,606 patients. Significant differences were detected between the ER+ (1%-9%) cohort and the other 2 cohorts on the basis of clinicopathological characteristics respectively. When taking all of the patients into analysis without consideration of treatment modality, the ER+ (1%-9%) cohort presented better prognosis than the ER- group in terms of 5-year disease-free survival (OR, 1.47; P = .046) and 5-year overall survival (OR, 1.23; P = .046). However, patients with ER+ (1%-9%) breast cancer who received endocrine therapy seemed to have a prognosis similar to those without any endocrine therapy (P = .684) and those with ER- carcinoma who received endocrine therapy (P = .145). Patients with ER+ (>= 10%) tumors had better endocrine responsiveness compared with their ER+ (1%-9%) counterparts (OR, 0.52; P = .034, ER+ [1%-9%] vs. ER+ [>= 10%]). Our results indicate that primary breast cancer patients with ER+ (1%-9%) expression gained no significant survival benefit from endocrine therapy, but manifested overall better prognosis than those with ER- cancer. (C) 2017 Elsevier Inc. All rights reserved.