标题：Protection of Spiral Ganglion Neurons and Prevention of Auditory Neuropathy
作者：Liu, Wenwen; Wang, Xue; Wang, Man; Wang, Haibo
作者机构：[Liu, Wenwen; Wang, Xue; Wang, Man; Wang, Haibo] Shandong Univ, Otolaryngol Head & Neck Surg, Shandong Prov ENT Hosp, Jinan, Shandong, Peoples R China 更多
通讯作者：Wang, HB;Wang, HB
通讯作者地址：[Wang, HB]Shandong Univ, Otolaryngol Head & Neck Surg, Shandong Prov ENT Hosp, Jinan, Shandong, Peoples R China;[Wang, HB]Shandong Prov Key Lab Otol, 更多
来源：HEARING LOSS: MECHANISMS, PREVENTION AND CURE
关键词：Spiral ganglion neuron; Synapse; Neuronal damage; Auditory neuropathy;; Cochlea implantation
摘要：In the auditory system, the primary sensory neurons, spiral ganglion neurons (SGNs), transmit complex acoustic information from hair cells to the second-order sensory neurons in the cochlear nucleus for sound processing, thus building the initial bridge between the physical world of sound and the perception of that sound. Cochlear SGN loss causes irreversible hearing impairment because this type of neural cell cannot regenerate. A better understanding of the molecular mechanisms of formation, structure, degeneration, and protection of SGNs will help to design potential therapeutic strategies for preservation and replacement of them in the cochlear implant recipient. In this review, we described and summarized the following about SGNs: (1) their cell biology and their peripheral and central connections, (2) mechanisms of their neuronal damage and their protection, and (3) the neural and synaptic mechanism of auditory neuropathy and current options for hearing rehabilitation from auditory neuropathy. The updates of the research progress and the significant issues on these topics were discussed.